Methyl CpG binding protein 2 (Q21499136)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z2D6

methyl-CpG binding protein MeCP2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z2D6

Methyl-CpG DNA binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

DNA-binding transcription factor activity

Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

MeCP2, a key contributor to neurological disease, activates and represses transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

5 June 2018

Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

MeCP2, a key contributor to neurological disease, activates and represses transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

transcription factor binding

1 reference

8 April 2019

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

protein binding

9 references

8 April 2019

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

MeCP2, a key contributor to neurological disease, activates and represses transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

mRNA binding

1 reference

8 April 2019

Components of the DNA methylation system of chromatin control are RNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

siRNA binding

1 reference

8 April 2019

Components of the DNA methylation system of chromatin control are RNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

DNA-binding transcription repressor activity, RNA polymerase II-specific

four-way junction DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

methyl-CpG binding

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

Components of the DNA methylation system of chromatin control are RNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

double-stranded methylated DNA binding

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

6 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

enzyme binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

chromatin DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

histone deacetylase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

unmethylated CpG binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

promoter-specific chromatin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

8 April 2019

Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

MeCP2, a key contributor to neurological disease, activates and represses transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

chromatin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

methyl-CpG binding

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Components of the DNA methylation system of chromatin control are RNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

double-stranded methylated DNA binding

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

cell component

cytoplasm

1 reference

8 April 2019

Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

postsynapse

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

mitochondrion

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

heterochromatin

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

nucleus

13 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

MeCP2, a key contributor to neurological disease, activates and represses transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

The major form of MeCP2 has a novel N-terminus generated by alternative splicing

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

Enhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

5 June 2018

Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

protein-containing complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

chromatin

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

heterochromatin

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

gamma-tubulin complex

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

nucleus

12 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

MeCP2, a key contributor to neurological disease, activates and represses transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Enhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

cytosol

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

1 reference

8 April 2019

TAS

biological process

response to hypoxia

1 reference

8 April 2019

Enhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

chemical synaptic transmission

1 reference

8 April 2019

Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2D6&geneProductId=UniProtKB:Q9Z2D6

1 reference

5 June 2018

regulation of synaptic plasticity

1 reference

8 April 2019

Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

long-term memory

1 reference

8 April 2019

Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

catecholamine secretion

1 reference

8 April 2019

Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

neuron projection development

1 reference

8 April 2019

The transcriptional repressor Mecp2 regulates terminal neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

sensory perception of pain

1 reference

8 April 2019

A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

long-term potentiation

1 reference

8 April 2019

Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

positive regulation of transcription, DNA-templated

respiratory gaseous exchange by respiratory system

1 reference

8 April 2019

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

excitatory postsynaptic potential

1 reference

8 April 2019

MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

startle response

1 reference

8 April 2019

A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

visual learning

1 reference

8 April 2019

Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

proprioception

brain development

1 reference

8 April 2019

Longitudinal brain MRI study in a mouse model of Rett Syndrome and the effects of choline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

pathogenesis

1 reference

8 April 2019

Enhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

nervous system process involved in regulation of systemic arterial blood pressure

1 reference

8 April 2019

Autonomic cardiovascular control in methyl-CpG-binding protein 2 (Mecp2) deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

memory

1 reference

8 April 2019

Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

protein localization

1 reference

8 April 2019

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

phosphatidylcholine metabolic process

1 reference

8 April 2019

Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

regulation of gene expression by genetic imprinting

1 reference

8 April 2019

Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

learning

neuron differentiation

1 reference

8 April 2019

The transcriptional repressor Mecp2 regulates terminal neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

multicellular organismal response to stress

1 reference

8 April 2019

Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

negative regulation of histone acetylation

1 reference

14 February 2019

MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

mitochondrial electron transport, ubiquinol to cytochrome c

1 reference

8 April 2019

Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

dendrite development

neuron maturation

3 references

8 April 2019

MeCP2 mutation causes distinguishable phases of acute and chronic defects in synaptogenesis and maintenance, respectively

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

glutamine metabolic process

1 reference

8 April 2019

Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

positive regulation of synapse assembly

1 reference

14 February 2019

MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

glucocorticoid metabolic process

1 reference

8 April 2019

Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

cardiolipin metabolic process

1 reference

8 April 2019

Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

adult locomotory behavior

neuromuscular process controlling posture

1 reference

8 April 2019

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

negative regulation of neuron apoptotic process

1 reference

8 April 2019

Enhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

regulation of gene expression, epigenetic

post-embryonic development

1 reference

8 April 2019

Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

regulation of respiratory gaseous exchange by nervous system process

inositol metabolic process

1 reference

8 April 2019

Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

behavioral fear response

regulation of gene expression

1 reference

8 April 2019

MeCP2-dependent repression of an imprinted miR-184 released by depolarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

ventricular system development

1 reference

8 April 2019

Longitudinal brain MRI study in a mouse model of Rett Syndrome and the effects of choline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

negative regulation of histone methylation

1 reference

14 February 2019

MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

cellular biogenic amine metabolic process

1 reference

8 April 2019

Defect in normal developmental increase of the brain biogenic amine concentrations in the mecp2-null mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

neuromuscular process

cerebellum development

1 reference

8 April 2019

Longitudinal brain MRI study in a mouse model of Rett Syndrome and the effects of choline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

negative regulation of transcription, DNA-templated

Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

MeCP2, a key contributor to neurological disease, activates and represses transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

negative regulation of smooth muscle cell differentiation

1 reference

8 April 2019

MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG-binding protein 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

positive regulation of histone H3-K9 trimethylation

1 reference

8 April 2019

MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG-binding protein 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation

1 reference

8 April 2019

MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG-binding protein 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

positive regulation of cell population proliferation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

positive regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

positive regulation of synaptic plasticity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

negative regulation of protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

social behavior

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

8 April 2019

A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

cellular response to potassium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

response to cocaine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

regulation of DNA methylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

negative regulation of astrocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

positive regulation of dendritic spine development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

negative regulation of dendritic spine development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

cellular response to isoquinoline alkaloid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

positive regulation of anterograde dense core granule transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

positive regulation of retrograde dense core granule transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

negative regulation of dendrite extension

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

positive regulation of dendrite extension

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

positive regulation of branching morphogenesis of a nerve

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

negative regulation of primary miRNA processing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

negative regulation of transcription by RNA polymerase II

regulation of transcription, DNA-templated

3 references

1 reference

8 April 2019

Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

response to radiation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

regulation of synapse organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2D6

has part(s)

methyl-CpG DNA binding

1 reference

InterPro Release 71.0