B cell leukemia/lymphoma 6 (Q21428928)

Zinc finger C2H2 superfamily

1 reference

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

BTB/POZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

4 references

24 April 2018

24 April 2018

Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

24 April 2018

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

24 April 2018

BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

sequence-specific DNA binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

24 April 2018

A putative silencer element in the IL-5 gene recognized by Bcl6

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

intronic transcription regulatory region sequence-specific DNA binding

1 reference

14 February 2019

A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

chromatin binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Bcl6 is a transcriptional repressor for the IL-18 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

1 reference

14 February 2019

protein binding

8 references

14 February 2019

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

A BCL6/BCOR/SIRT1 complex triggers neurogenesis and suppresses medulloblastoma by repressing Sonic Hedgehog signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

DNA-binding transcription repressor activity, RNA polymerase II-specific

nucleic acid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

1 reference

14 February 2019

chromatin DNA binding

1 reference

14 February 2019

Bcl6 controls granzyme B expression in effector CD8+ T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

A putative silencer element in the IL-5 gene recognized by Bcl6

3 references

14 February 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

5 references

14 February 2019

14 February 2019

BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

cell component

nucleus

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

24 April 2018

A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

24 April 2018

BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

nucleus

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

positive regulation of histone deacetylation

biological process

1 reference

14 February 2019

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

protein localization

1 reference

14 February 2019

BCL6 suppresses RhoA activity to alter macrophage morphology and motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

negative regulation of T-helper 2 cell differentiation

1 reference

14 February 2019

Inhibition of Th2 differentiation and GATA-3 expression by BCL-6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

negative regulation of mast cell cytokine production

1 reference

14 February 2019

Bcl6 regulates Th2 type cytokine productions by mast cells activated by FcepsilonRI/IgE cross-linking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

1 reference

24 April 2018

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

1 reference

14 February 2019

regulation of transcription by RNA polymerase II

1 reference

14 February 2019

A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

regulation of GTPase activity

1 reference

14 February 2019

BCL6 suppresses RhoA activity to alter macrophage morphology and motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

negative regulation of cell differentiation

1 reference

14 February 2019

Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

germinal center formation

4 references

14 February 2019

Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

negative regulation of Rho protein signal transduction

1 reference

14 February 2019

BCL6 suppresses RhoA activity to alter macrophage morphology and motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

negative regulation of isotype switching to IgE isotypes

Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

negative regulation of transcription by RNA polymerase II

14 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

ISO

14 February 2019

BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

A putative silencer element in the IL-5 gene recognized by Bcl6

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Bcl6 controls granzyme B expression in effector CD8+ T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

A putative silencer element in the IL-5 gene recognized by Bcl6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Bcl6 is a transcriptional repressor for the IL-18 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

14 February 2019

Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

1 reference

24 April 2018

type 2 immune response

1 reference

24 April 2018

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

negative regulation of cell-matrix adhesion

1 reference

14 February 2019

BCL6 suppresses RhoA activity to alter macrophage morphology and motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

regulation of cell population proliferation

1 reference

24 April 2018

Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

positive regulation of B cell proliferation

1 reference

14 February 2019

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

Rho protein signal transduction

1 reference

14 February 2019

BCL6 suppresses RhoA activity to alter macrophage morphology and motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

spermatogenesis

1 reference

14 February 2019

Testicular germ cell apoptosis in Bcl6-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

regulation of memory T cell differentiation

1 reference

14 February 2019

Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

positive regulation of neuron differentiation

1 reference

14 February 2019

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

regulation of inflammatory response

1 reference

24 April 2018

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41183&geneProductId=UniProtKB:P41183

negative regulation of type 2 immune response

1 reference

14 February 2019

BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

B cell differentiation

1 reference

14 February 2019

Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

1 reference

14 February 2019

actin cytoskeleton organization

1 reference

14 February 2019

BCL6 suppresses RhoA activity to alter macrophage morphology and motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

negative regulation of Notch signaling pathway

1 reference

14 February 2019

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

erythrocyte development

1 reference

14 February 2019

Abnormal erythroid differentiation in neonatal bcl-6-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

negative regulation of cellular senescence

1 reference

14 February 2019

ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41183

regulation of cell population proliferation

has part(s)

Zinc finger C2H2-type

1 reference

BTB/POZ domain

1 reference