Ubiquitin conjugating enzyme E2 D2 (Q21130841)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62837

Peroxisomal Protein Importer

1 reference

Transporter Classification Database ID

3.A.20.1.1

hierarchical database ID heuristic

2 October 2019

based on heuristic

Ubiquitin-conjugating enzyme E2 family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin-conjugating enzyme, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

1 reference

8 April 2019

ubiquitin-protein transferase activity

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

protein binding

18 references

8 April 2019

Molecular basis of Pirh2-mediated p53 ubiquitylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Defining the human deubiquitinating enzyme interaction landscape

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Functional proteomics mapping of a human signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Turning the RING domain protein MdmX into an active ubiquitin-protein ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

1 reference

8 April 2019

ubiquitin conjugating enzyme activity

5 references

31 October 2017

Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

31 October 2017

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

31 October 2017

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

31 October 2017

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

31 October 2017

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

ubiquitin protein ligase binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

ubiquitin conjugating enzyme activity

Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

1 reference

8 April 2019

ubiquitin ligase complex

1 reference

31 October 2017

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

1 reference

8 April 2019

extracellular exosome

1 reference

31 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

protein-containing complex

1 reference

8 April 2019

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

extracellular exosome

HDA

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

ubiquitin-dependent protein catabolic process

HDA

biological process

1 reference

31 October 2017

Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

protein polyubiquitination

1 reference

8 April 2019

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

stimulatory C-type lectin receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

1 reference

31 October 2017

TRIF-dependent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

1 reference

8 April 2019

Fc-epsilon receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

1 reference

31 October 2017

protein K48-linked ubiquitination

1 reference

31 October 2017

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

regulation of transcription from RNA polymerase II promoter in response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

1 reference

31 October 2017

T cell receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837

1 reference

31 October 2017

protein autoubiquitination

1 reference

8 April 2019

Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

protein ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

8 April 2019

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

8 April 2019

Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

1 reference

8 April 2019

ubiquitin-dependent protein catabolic process

protein targeting to peroxisome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

1 reference

8 April 2019

protein K11-linked ubiquitination

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837

http://www.uniprot.org/uniprot/P62837.txt?version=137

EC enzyme number

2.3.2.24

1 reference

14 November 2015

has part(s)

Ubiquitin-conjugating enzyme E2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62837

Ubiquitin-conjugating enzyme, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62837

Identifiers

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

3.A.20.1.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database