Rho associated coiled-coil containing protein kinase 2 (Q21127094)

PH-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

pleckstrin homology domain, protein family

1 reference

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

Rho binding domain, protein family

1 reference

Rho-associated protein kinase 2, HR1 domain, protein family

1 reference

AGC-kinase, C-terminal domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

structural molecule activity

1 reference

9 May 2019

Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

protein serine/threonine kinase activity

Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24

5 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116

31 October 2017

31 October 2017

Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116

31 October 2017

Rho Kinase II Phosphorylation of the Lipoprotein Receptor LR11/SORLA Alters Amyloid-β Production

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116

Rho-dependent protein serine/threonine kinase activity

1 reference

31 October 2017

Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2/moesin cascade

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116

RNA binding

1 reference

31 October 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116

RNA binding

HDA

1 reference

9 May 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

protein serine/threonine kinase activity

HDA

Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

8 April 2019

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

8 April 2019

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

8 April 2019

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

8 April 2019

Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

8 April 2019

8 April 2019

Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

8 April 2019

Rho Kinase II Phosphorylation of the Lipoprotein Receptor LR11/SORLA Alters Amyloid-β Production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

tau protein binding

1 reference

9 May 2019

Roles of tau protein in health and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

tau-protein kinase activity

1 reference

9 May 2019

Roles of tau protein in health and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

Rho-dependent protein serine/threonine kinase activity

protein serine/threonine kinase activity

Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24

10 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

9 May 2019

Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

Rho Kinase II Phosphorylation of the Lipoprotein Receptor LR11/SORLA Alters Amyloid-β Production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

Rho-dependent protein serine/threonine kinase activity

Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2/moesin cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

8 April 2019

centrosome

1 reference

8 April 2019

Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

microtubule organizing center

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

cytoplasmic ribonucleoprotein granule

1 reference

9 May 2019

The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs

GOA

curator

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

8 April 2019

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

positive regulation of protein phosphorylation

biological process

1 reference

9 May 2019

Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2/moesin cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

intracellular signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

centrosome duplication

1 reference

9 May 2019

Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

rhythmic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

ephrin receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

cellular response to testosterone stimulus

1 reference

9 May 2019

Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2/moesin cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

cytokinesis

1 reference

31 October 2017

Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116

positive regulation of centrosome duplication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

regulation of stress fiber assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

regulation of cell motility

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

positive regulation of endothelial cell migration

1 reference

9 May 2019

Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2/moesin cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

protein phosphorylation

Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

9 May 2019

Regulation of RhoA-dependent ROCKII activation by Shp2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

negative regulation of bicellular tight junction assembly

1 reference

9 May 2019

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

vascular endothelial growth factor receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

positive regulation of gene expression

1 reference

31 October 2017

Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2/moesin cascade

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116

regulation of cell adhesion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

regulation of circadian rhythm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

Rho protein signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

8 April 2019

regulation of focal adhesion assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

negative regulation of angiogenesis

1 reference

9 May 2019

Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

regulation of keratinocyte differentiation

1 reference

9 May 2019

Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

negative regulation of myosin-light-chain-phosphatase activity

I-kappaB kinase/NF-kappaB signaling

1 reference

9 May 2019

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

regulation of establishment of cell polarity

1 reference

9 May 2019

Rho‐kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

cortical actin cytoskeleton organization

regulation of establishment of endothelial barrier

actin cytoskeleton organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

protein localization to plasma membrane

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

aortic valve morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

positive regulation of cardiac muscle hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

peptidyl-threonine phosphorylation

1 reference

1 January 2018

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116

positive regulation of cell migration

1 reference

9 May 2019

Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma

GOA

curator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

positive regulation of connective tissue growth factor production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

positive regulation of MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

regulation of protein metabolic process

1 reference

9 May 2019

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

positive regulation of stress fiber assembly

1 reference

9 May 2019

Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma

GOA

curator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

negative regulation of biomineral tissue development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

response to transforming growth factor beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

positive regulation of fibroblast growth factor production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

regulation of angiotensin-activated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

negative regulation of protein localization to lysosome

1 reference

9 May 2019

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

positive regulation of protein localization to early endosome

1 reference

9 May 2019

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

positive regulation of amyloid precursor protein catabolic process

positive regulation of connective tissue replacement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

response to angiotensin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

response to ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

negative regulation of gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

peptidyl-threonine phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

3 references

8 April 2019

8 April 2019

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

8 April 2019

Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

regulation of nervous system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

mRNA destabilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

blood vessel diameter maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

regulation of cellular response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

cellular response to acetylcholine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

1 reference

9 May 2019

mitotic cytokinesis

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

peptidyl-threonine phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

4 references

9 May 2019

9 May 2019

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

cortical actin cytoskeleton organization

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

actomyosin structure organization

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

embryonic morphogenesis

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

regulation of cell junction assembly

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5181

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

5290

English

17 August 2016

has part(s)

AGC-kinase, C-terminal

1 reference

pleckstrin homology domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

serine/threonine-protein kinase, active site

1 reference

Rho binding domain

1 reference

Rho-associated protein kinase 2, HR1 domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016