Nuclear factor of activated T cells 2 (Q21121619)

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mammalian protein found in Homo sapiens

T cell transcription factor NFAT1
NF-ATp
NFATC2
T-cell transcription factor NFAT1
preexisting nuclear factor of activated T-cells 2
NFAT pre-existing subunit
NF-ATc2
nuclear factor of activated T-cells, preexisting component
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFAT transcription complex, preexisting component
nuclear factor of activated T-cells, cytoplasmic 2

Language	Label	Description	Also known as
English	Nuclear factor of activated T cells 2	mammalian protein found in Homo sapiens	T cell transcription factor NFAT1 NF-ATp NFATC2 T-cell transcription factor NFAT1 preexisting nuclear factor of activated T-cells 2 NFAT pre-existing subunit NF-ATc2 nuclear factor of activated T-cells, preexisting component nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NFAT transcription complex, preexisting component nuclear factor of activated T-cells, cytoplasmic 2

Statements

1 reference

13 November 2019

UniProt protein ID

p53-like transcription factor, DNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13469

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13469

Nuclear factor of activated T cells (NFAT)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13469

Rel homology domain (RHD), DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13469

Immunoglobulin E-set

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13469

IPT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rel homology dimerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rel homology domain (RHD), DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method or standard

3 references

8 April 2019

Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

sequence-specific DNA binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

DNA-binding transcription factor activity

determination method or standard

3 references

24 April 2018

Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

transcription factor binding

determination method or standard

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

chromatin binding

determination method or standard

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method or standard

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

protein binding

determination method or standard

10 references

8 April 2019

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

FOXP3 controls regulatory T cell function through cooperation with NFAT

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

USP22 is a positive regulator of NFATc2 on promoting IL2 expression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

transcription cis-regulatory region binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

phosphatase binding

determination method or standard

1 reference

8 April 2019

Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method or standard

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

DNA-binding transcription factor activity

determination method or standard

4 references

8 April 2019

Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

determination method or standard

4 references

8 April 2019

Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

transcription regulator complex

determination method or standard

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

determination method or standard

5 references

24 April 2018

Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

24 April 2018

Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

24 April 2018

Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

determination method or standard

ribonucleoprotein complex

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

determination method or standard

6 references

8 April 2019

Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

biological process

B cell receptor signaling pathway

determination method or standard

1 reference

8 April 2019

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

cytokine production

determination method or standard

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

calcineurin-NFAT signaling cascade

determination method or standard

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

transcription by RNA polymerase II

determination method or standard

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

myotube cell development

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

cellular response to DNA damage stimulus

determination method or standard

1 reference

8 April 2019

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

Fc-epsilon receptor signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

positive regulation of myoblast fusion

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

positive regulation of gene expression

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

positive regulation of B cell proliferation

determination method or standard

1 reference

8 April 2019

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

determination method or standard

1 reference

8 April 2019

NFAT promotes carcinoma invasive migration through glypican-6

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13469&geneProductId=UniProtKB:Q13469

determination method or standard

regulation of regulatory T cell differentiation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

negative regulation of vascular associated smooth muscle cell differentiation

determination method or standard

1 reference

8 April 2019

MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13469

determination method or standard

Rel homology domain (RHD), DNA-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13469

Rel homology dimerisation domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13469

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13469

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000360619

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360619

ENSP00000379330

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000379330

ENSP00000396471

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000396471

ENSP00000477142

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477142

ENSP00000477342

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477342

ENSP00000477370

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477370

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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