Programmed cell death 6 interacting protein (Q21114029)

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mammalian protein found in Homo sapiens
  • dopamine receptor interacting protein 4
  • Hp95
  • ALG-2-interacting protein X
  • ALG-2-interacting protein 1
  • ALG-2 interacting protein 1
  • PDCD6-interacting protein
  • programmed cell death 6-interacting protein
  • PDCD6IP
  • apoptosis-linked gene 2-interacting protein X
edit
Language Label Description Also known as
English
Programmed cell death 6 interacting protein
mammalian protein found in Homo sapiens
  • dopamine receptor interacting protein 4
  • Hp95
  • ALG-2-interacting protein X
  • ALG-2-interacting protein 1
  • ALG-2 interacting protein 1
  • PDCD6-interacting protein
  • programmed cell death 6-interacting protein
  • PDCD6IP
  • apoptosis-linked gene 2-interacting protein X

Statements

molecular function
protein binding
determination method or standard
IPI
28 references
retrieved
8 April 2019
stated in
The Protein Network of HIV Budding
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Syndecan-syntenin-ALIX regulates the biogenesis of exosomes
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Phe105 Loop of Alix Bro1 Domain Plays a Key Role in HIV-1 Release
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
A physical interaction network of dengue virus and human proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Two Distinct Binding Modes Define the Interaction of Brox with the C-Terminal Tails of CHMP5 and CHMP4B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein interactions of the transcription factor Hoxa1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
TEX14 interacts with CEP55 to block cell abscission
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
ALIX-CHMP4 interactions in the human ESCRT pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
retrieved
8 April 2019
stated in
Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IPI
cell component
extracellular exosome
determination method or standard
IDA
IEA
10 references
retrieved
31 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WUM4&geneProductId=UniProtKB:Q8WUM4
determination method or standard
IEA
retrieved
31 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WUM4&geneProductId=UniProtKB:Q8WUM4
determination method or standard
IEA
retrieved
31 October 2017
stated in
Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WUM4&geneProductId=UniProtKB:Q8WUM4
determination method or standard
IDA
retrieved
31 October 2017
stated in
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WUM4&geneProductId=UniProtKB:Q8WUM4
determination method or standard
IDA
retrieved
31 October 2017
stated in
Identification and proteomic profiling of exosomes in human urine
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WUM4&geneProductId=UniProtKB:Q8WUM4
determination method or standard
IDA
retrieved
31 October 2017
stated in
Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WUM4&geneProductId=UniProtKB:Q8WUM4
determination method or standard
IDA
retrieved
31 October 2017
stated in
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WUM4&geneProductId=UniProtKB:Q8WUM4
determination method or standard
IDA
retrieved
31 October 2017
stated in
Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WUM4&geneProductId=UniProtKB:Q8WUM4
determination method or standard
IDA
retrieved
31 October 2017
stated in
Large-scale proteomics and phosphoproteomics of urinary exosomes
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WUM4&geneProductId=UniProtKB:Q8WUM4
determination method or standard
IDA
retrieved
31 October 2017
stated in
Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WUM4&geneProductId=UniProtKB:Q8WUM4
determination method or standard
IDA
extracellular exosome
determination method or standard
HDA
IDA
IEA
9 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IEA
retrieved
8 April 2019
stated in
Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IDA
retrieved
8 April 2019
stated in
Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IDA
retrieved
8 April 2019
stated in
Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IDA
retrieved
8 April 2019
stated in
Identification and proteomic profiling of exosomes in human urine
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
IDA
retrieved
8 April 2019
stated in
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
HDA
retrieved
8 April 2019
stated in
Large-scale proteomics and phosphoproteomics of urinary exosomes
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
HDA
retrieved
8 April 2019
stated in
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
GOA
curator
UniProt
UniProt protein ID
Q8WUM4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WUM4
determination method or standard
HDA
biological process

Identifiers

PDB structure ID
 
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