Tumor protein p53 binding protein 1 (Q21107570)

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mammalian protein found in Homo sapiens
  • TP53-binding protein 1
  • p53-binding protein 1
  • tumor protein 53-binding protein, 1
  • tumor suppressor p53-binding protein 1
  • TP53BP1
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Language Label Description Also known as
English
Tumor protein p53 binding protein 1
mammalian protein found in Homo sapiens
  • TP53-binding protein 1
  • p53-binding protein 1
  • tumor protein 53-binding protein, 1
  • tumor suppressor p53-binding protein 1
  • TP53BP1

Statements

molecular function
protein binding
determination method or standard
IPI
33 references
retrieved
8 April 2019
stated in
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
GOA
curator
UniProt
UniProt protein ID
Q12888
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1
GOA
curator
UniProt
UniProt protein ID
Q12888
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response
GOA
curator
UniProt
UniProt protein ID
Q12888
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function
GOA
curator
UniProt
UniProt protein ID
Q12888
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells.
GOA
curator
UniProt
UniProt protein ID
Q12888
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 is regulated by the lysine demethylase LSD1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDC1 is a mediator of the mammalian DNA damage checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
Factors determining DNA double-strand break repair pathway choice in G2 phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tudor, MBT and chromo domains gauge the degree of lysine methylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
retrieved
8 April 2019
stated in
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888
determination method or standard
IPI
cell component
biological process

Identifiers

PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21107570&oldid=2022930792"