ERCC excision repair 6, chromatin remodeling factor (Q21106758)

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mammalian protein found in Homo sapiens

ATP-dependent helicase ERCC6
Cockayne syndrome group B protein
Chimeric ERCC6-PGBD3 protein
excision repair cross-complementation group 6
DNA excision repair protein ERCC-6
ERCC6
cockayne syndrome protein CSB
ERCC6-PGBD3 fusion protein
Chimeric CSB-PGBD3 protein
excision repair cross-complementing rodent repair deficiency, complementation group 6

Language	Label	Description	Also known as
English	ERCC excision repair 6, chromatin remodeling factor	mammalian protein found in Homo sapiens	ATP-dependent helicase ERCC6 Cockayne syndrome group B protein Chimeric ERCC6-PGBD3 protein excision repair cross-complementation group 6 DNA excision repair protein ERCC-6 ERCC6 cockayne syndrome protein CSB ERCC6-PGBD3 fusion protein Chimeric CSB-PGBD3 protein excision repair cross-complementing rodent repair deficiency, complementation group 6

Statements

1 reference

22 April 2020

UniProt protein ID

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q03468

SNF2-like, N-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q03468

Helicase superfamily 1/2, ATP-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Helicase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SNF2-related, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

22 April 2020

UniProt protein ID

1 reference

22 April 2020

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

ATP-dependent activity, acting on DNA

determination method or standard

3 references

8 April 2019

Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

protein tyrosine kinase activator activity

determination method or standard

1 reference

8 April 2019

Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

helicase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

protein N-terminus binding

determination method or standard

1 reference

8 April 2019

The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

chromatin binding

determination method or standard

1 reference

8 April 2019

Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

DNA helicase activity

determination method or standard

1 reference

8 April 2019

Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

protein C-terminus binding

determination method or standard

1 reference

8 April 2019

Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

protein binding

determination method or standard

7 references

8 April 2019

Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

p53 modulation of TFIIH–associated nucleotide excision repair activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

RNA polymerase binding

determination method or standard

1 reference

21 June 2018

CSB-PGBD3 Mutations Cause Premature Ovarian Failure

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03468&geneProductId=UniProtKB:Q03468

determination method or standard

protein-containing complex binding

determination method or standard

1 reference

8 April 2019

Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

determination method or standard

transcription elongation factor complex

determination method or standard

1 reference

8 April 2019

Cockayne syndrome group B protein enhances elongation by RNA polymerase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

biological process

pyrimidine dimer repair

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

epigenetic maintenance of chromatin in transcription-competent conformation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

response to superoxide

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03468&geneProductId=UniProtKB:Q03468

determination method or standard

multicellular organism growth

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

regulation of DNA-templated transcription, elongation

determination method or standard

1 reference

8 April 2019

Cockayne syndrome group B protein enhances elongation by RNA polymerase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03468&geneProductId=UniProtKB:Q03468

determination method or standard

positive regulation of DNA-templated transcription, elongation

determination method or standard

1 reference

8 April 2019

Cockayne syndrome group B protein enhances elongation by RNA polymerase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

transcription elongation from RNA polymerase I promoter

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

intrinsic apoptotic signaling pathway in response to DNA damage

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

response to UV-B

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

photoreceptor cell maintenance

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

response to gamma radiation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

response to toxic substance

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

response to X-ray

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

base-excision repair

determination method or standard

1 reference

8 April 2019

Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

response to oxidative stress

determination method or standard

3 references

8 April 2019

Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

positive regulation of protein tyrosine kinase activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

transcription-coupled nucleotide-excision repair

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

The ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

determination method or standard

3 references

21 June 2018

CSB-PGBD3 Mutations Cause Premature Ovarian Failure

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03468&geneProductId=UniProtKB:Q03468

determination method or standard

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03468&geneProductId=UniProtKB:Q03468

determination method or standard

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03468&geneProductId=UniProtKB:Q03468

determination method or standard

DNA duplex unwinding

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

positive regulation of DNA repair

determination method or standard

2 references

8 April 2019

The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

8 April 2019

The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03468

determination method or standard

Helicase superfamily 1/2, ATP-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q03468

Helicase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q03468

SNF2-related, N-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q03468

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

22 April 2020

UniProt protein ID

Ensembl protein ID

ENSP00000348089

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000348089

ENSP00000363242

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363242

ENSP00000422827

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422827

ENSP00000485163

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485163

ENSP00000423550

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423550

ENSP00000387966

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000387966

PDB structure ID

1 reference

UniProt protein ID

30 June 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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