Calcium voltage-gated channel auxiliary subunit alpha2delta 1 (Q21105498)

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mammalian protein found in Homo sapiens

CACNA2D1
dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit
calcium channel, voltage-dependent, alpha 2/delta subunit 1
voltage-dependent calcium channel subunit alpha-2/delta-1
calcium channel, L type, alpha 2 polypeptide
voltage-gated calcium channel subunit alpha-2/delta-1

Language	Label	Description	Also known as
English	Calcium voltage-gated channel auxiliary subunit alpha2delta 1	mammalian protein found in Homo sapiens	CACNA2D1 dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit calcium channel, voltage-dependent, alpha 2/delta subunit 1 voltage-dependent calcium channel subunit alpha-2/delta-1 calcium channel, L type, alpha 2 polypeptide voltage-gated calcium channel subunit alpha-2/delta-1

Statements

1 reference

13 November 2019

UniProt protein ID

von Willebrand factor A-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54289

calcium channel auxiliary subunit alpha2delta

1 reference

based on heuristic

hierarchical database ID heuristic

VWA N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

von Willebrand factor, type A, protein family

1 reference

based on heuristic

inferred from protein domain or family

Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

voltage-gated calcium channel activity

determination method or standard

3 references

3 January 2017

Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method or standard

3 January 2017

Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method or standard

3 January 2017

Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

voltage-gated ion channel activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

calcium channel activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

determination method or standard

1 reference

8 April 2019

Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

voltage-gated calcium channel activity involved in bundle of His cell action potential

determination method or standard

1 reference

8 April 2019

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

voltage-gated calcium channel activity

determination method or standard

5 references

8 April 2019

A β‐amyloid oligomer directly modulates P/Q‐type calcium currents in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

8 April 2019

Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

8 April 2019

Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

8 April 2019

Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

voltage-gated calcium channel complex

determination method or standard

L-type voltage-gated calcium channel complex

determination method or standard

1 reference

3 January 2017

Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

plasma membrane

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

extracellular exosome

determination method or standard

3 references

3 January 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method or standard

3 January 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method or standard

3 January 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

sarcoplasmic reticulum

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

voltage-gated calcium channel complex

determination method or standard

3 references

8 April 2019

Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

8 April 2019

Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

L-type voltage-gated calcium channel complex

determination method or standard

biological process

regulation of ion transmembrane transport

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

cardiac conduction

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

calcium ion transmembrane transport

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

calcium ion transport

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

8 April 2019

Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

8 April 2019

Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

determination method or standard

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method or standard

cardiac muscle cell action potential involved in contraction

determination method or standard

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

calcium ion transport into cytosol

determination method or standard

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

positive regulation of high voltage-gated calcium channel activity

determination method or standard

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

regulation of heart rate by cardiac conduction

determination method or standard

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

calcium ion transmembrane transport via high voltage-gated calcium channel

determination method or standard

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

regulation of ventricular cardiac muscle cell membrane repolarization

determination method or standard

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

regulation of membrane repolarization during action potential

determination method or standard

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

membrane depolarization during bundle of His cell action potential

determination method or standard

1 reference

8 April 2019

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

calcium ion import across plasma membrane

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

determination method or standard

1 reference

8 April 2019

A β‐amyloid oligomer directly modulates P/Q‐type calcium currents in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

cellular response to amyloid-beta

determination method or standard

1 reference

8 April 2019

A β‐amyloid oligomer directly modulates P/Q‐type calcium currents in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method or standard

physically interacts with

bepridil hydrochloride monohydrate

object of statement has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200382

von Willebrand factor, type A

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54289

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54289

Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54289

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000348589

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000348589

ENSP00000349320

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000349320

ENSP00000405395

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000405395

ENSP00000409374

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409374

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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