二硫化イリジウム
IRS2
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/09/07 22:35 UTC 版)
IRS2（insulin receptor substrate 2、インスリン受容体基質2）は、ヒトではIRS2遺伝子によってコードされるタンパク質である[5]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000185950 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038894 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain”. J Biol Chem 272 (40): 25267–74. (Oct 1997). doi:10.1074/jbc.272.40.25267. PMID 9312143.
- ^ “Entrez Gene: IRS2 insulin receptor substrate 2”. 2021年9月7日閲覧。
- ^ “Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes”. J. Clin. Invest. 114 (7): 908–16. (October 2004). doi:10.1172/JCI22217. PMC 518668. PMID 15467829.
- ^ “Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation”. J. Neurosci. 23 (18): 7084–92. (August 2003). doi:10.1523/JNEUROSCI.23-18-07084.2003. PMC 6740672. PMID 12904469.
- ^ “IL-13 induces tyrosine phosphorylation of phospholipase C gamma-1 following IRS-2 association in human monocytes: relationship with the inhibitory effect of IL-13 on ROI production”. Biochem. Biophys. Res. Commun. 244 (3): 665–70. (March 1998). doi:10.1006/bbrc.1998.8314. PMID 9535722.
- ^ “SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2”. J. Biol. Chem. 277 (44): 42394–8. (November 2002). doi:10.1074/jbc.C200444200. PMID 12228220.
- ^ “Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling”. J. Biol. Chem. 271 (46): 29415–21. (November 1996). doi:10.1074/jbc.271.46.29415. PMID 8910607.
- ^ “Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation”. J. Biol. Chem. 272 (42): 26173–8. (October 1997). doi:10.1074/jbc.272.42.26173. PMID 9334184.
- ^ “Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling”. J. Biol. Chem. 273 (51): 34543–50. (December 1998). doi:10.1074/jbc.273.51.34543. PMID 9852124.
- ^ “An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events”. Diabetologia 45 (5): 657–67. (May 2002). doi:10.1007/s00125-002-0798-5. PMID 12107746.
[続きの解説]
- IRS2のページへのリンク
