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    WBC Abnormalities

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    Majj Majj
    This document discusses various morphologic abnormalities that can be seen in white blood cells. It describes 9 abnormalities that can be seen in granulocytes, including Alder-Reilly granules, Auer rods, Chediak-Higashi granules, Dohle bodies, May-Hegglin anomaly, hypersegmented neutrophils, LE cells, Pelger Huet anomaly, and toxic granulation. It also outlines 4 abnormalities seen in lymphocytes, which are basket cells, flame cells, grape cells, and reactive lymphocytes. The document provides brief descriptions of each abnormality and their associated conditions.

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    WBC Abnormalities

    Uploaded by

    Majj Majj
    233 views37 pages
    This document discusses various morphologic abnormalities that can be seen in white blood cells. It describes 9 abnormalities that can be seen in granulocytes, including Alder-Reilly granules, Auer rods, Chediak-Higashi granules, Dohle bodies, May-Hegglin anomaly, hypersegmented neutrophils, LE cells, Pelger Huet anomaly, and toxic granulation. It also outlines 4 abnormalities seen in lymphocytes, which are basket cells, flame cells, grape cells, and reactive lymphocytes. The document provides brief descriptions of each abnormality and their associated conditions.

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    Wbc Abnormalities

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    This document discusses various morphologic abnormalities that can be seen in white blood cells. It describes 9 abnormalities that can be seen in granulocytes, including Alder-Reilly granules, Auer rods, Chediak-Higashi granules, Dohle bodies, May-Hegglin anomaly, hypersegmented neutrophils, LE cells, Pelger Huet anomaly, and toxic granulation. It also outlines 4 abnormalities seen in lymphocytes, which are basket cells, flame cells, grape cells, and reactive lymphocytes. The document provides brief descriptions of each abnormality and their associated conditions.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    233 views37 pages

    WBC Abnormalities

    Uploaded by

    Majj Majj
    This document discusses various morphologic abnormalities that can be seen in white blood cells. It describes 9 abnormalities that can be seen in granulocytes, including Alder-Reilly granules, Auer rods, Chediak-Higashi granules, Dohle bodies, May-Hegglin anomaly, hypersegmented neutrophils, LE cells, Pelger Huet anomaly, and toxic granulation. It also outlines 4 abnormalities seen in lymphocytes, which are basket cells, flame cells, grape cells, and reactive lymphocytes. The document provides brief descriptions of each abnormality and their associated conditions.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 37

    WBC Abnormalities

    Carlo Chris S. Apurillo,RMT


    Instructor, Clinical Hematology College of Medical Technology

    Morphologic Abnormalities of Granulocytes

    1. Alder-Reilly anomaly
    Large,

    coarse, dark metachromatic granules Found in genetic mucopolysaccharidoses lack of lysosomal enzymes to break down mucopolysaccharides

    1. Alder-Reilly anomaly

    2. Auer Rods
    Pink/red

    rod like bodies fused with granules Associated with APL (M3) acute promyelocytic leukemia

    2. Auer Rods

    3. Chediak Higashi Granules


    Large,

    round blue gray

    bodies Chediak Higashi syndrome rare autosomal recessive condition associated with abnormally large leukocyte granules resulting from fusion of lysozymes

    3. Chediak Higashi Granules

    4. Dohle bodies
    small,

    oval inclusions in the cytoplasm of PMNs that stain pale blue with Wrights stain. Aggregates of free ribosomes Associated with severe infection

    4. Dohle bodies

    4. Dohle bodies

    5. May-Hegglin Anomaly
    Rare

    autosomal dominant condition characterized by presence of pale blue inclusions resembling Dohle bodies in neutrophils Larger and more prominent than Dohle bodies Characterized by giant plts

    5. May-Hegglin Anomaly

    6. Hypersegmented neutrophil
    Neutrophil

    with more than 5 segments Due to abnormal DNA synthesis Found in: megaloblastic anemia Shift to the right

    6. Hypersegmented neutrophil

    7. LE Cell
    Large,

    round, purple homogenous inclusion surrounded by flattened nuclei. Found in Systemic lupus erythematosus

    7. LE Cell

    8. Pelger Huet Anomaly


    Single

    or bilobed nucleus (hyposegmentation) Hereditary, autosomal dominant condition which involves failure of normal segmentation of granulocytic nuclei

    8. Pelger Huet Anomaly

    9. Toxic granulation
    Large

    dark blue to purple cytoplasmic granules in the metamyelocyte, and, or neutrohil stage. Primary granule enhancement Found in severe infections, toxic states, burns, malignancy and chemical poisoning

    9. Toxic granulation

    9. Toxic vacuoles
    Large,

    empty white areas End stage phagocytosis Found in: septicemia, severe infections, toxic states.

    Morphologic Abnormalities of Lymphocytes

    1. Basket Cell/Smudge cell


    Degenerated

    nucleus, ruptured cell due to its fragility Found in: chronic lymphocytic leukemia Artifact if few

    1. Basket Cell/Smudge cell

    2. Flame cell
    Plasma

    cell with pink to red cytoplasm Increase IgA (multiple myeloma)

    3. Grape Cell/Mott Cell


    Also

    known as Russel bodies Vacuolated plasma cell Found in multiple myeloma; reactive states

    3. Grape Cell/Mott Cell

    4. Reactive Lymphocytes
    Also

    known as Atypical lymphocytes or Downey Cell Type I Vacuolated Type II Stress lymphocyte Type III Lymphoblast like

    4. Reactive Lymphocytes
    >20%

    - infectious mononucleosis, viral Hepa <20% - pneumonia, systemic allergy, TB, toxoplasmosis

    Review!

    Alder-Reilly granules

    Chediak Higashi granules


    Auer Rods

    Review!

    May-Hegglin anomaly

    Dohle bodies

    hypersegmentation

    Review!

    LE Cell

    Pelger Huet

    Review!

    Basket cell Toxic granulation

    Review!

    Flame cell

    Grape cell

    Review!

    Atypical lymphocytes

    The end

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