Scribd Logo
Upload

Welcome to Scribd!

  • 2 views

    Teknologi Sediaan Semi Solid

    Uploaded by

    Irsan Jaya

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd

    Teknologi Sediaan Semi Solid

    Uploaded by

    Irsan Jaya
    2 views22 pages

    Original Title

    TEKNOLOGI SEDIAAN SEMI SOLID

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    2 views22 pages

    Teknologi Sediaan Semi Solid

    Uploaded by

    Irsan Jaya

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 22

    SEMI SOLID

    PREPARATIONS

    IRSAN
    JAYA
    SEMI
    SOLIDS

    Are topical preparations


    intended for application
    on the skin or mucosa
    membranes to provide
    local and sometimes
    systemic effects.
    EFFECT
    S
    Local Systemic
    Effect Effect
    It is used externally
    The probability of side effects can be
    reduced
    Advantages
    First, pass gut and hepatic metabolism is
    avoided.
    Local action and Site-specific action of the
    drug on the affected area.
    Convenient for unconscious patients or
    patients to have difficulty in oral
    administration.
    Suitable dosage form for bitter drugs.
    More stable than a liquid dosage form
    The accuracy can't be measured
    May cause staining.
    Disadvantages

    They are bulky to handle.


    Application with a finger may cause
    contamination.
    Physico-chemical is less stable than a
    solid dosage form.
    May cause irritation or allergy in some
    patients
    Smooth texture
    Ideal Properties Elegant in appearance
    Non-dehydrating
    Non-gritty
    Non-greasy and non-
    staining
    Non-hygroscopic
    Bases
    Preservative

    Ingredients
    Humectants
    Antioxidants
    Emulsifier
    Gelling agent
    Permeation
    enhancer
    Buffers
    OINT
    MENT

    SEMISOLI
    D CRE
    GEL PREPARAT AM
    IONS

    PAS
    TE
    • Ointment is a semi-solid
    preparation containing
    <20% water and >50%
    hydrocarbons, intended for
    topical use on the skin or
    mucous membranes to
    soothe or heal wounds,
    burns, rashes, scrapes, or
    other skin problems. Also
    OINTMEN
    called unguent.
    T
    Ointment
    Base
    - Increases hydration on - Sticky texture
    the skin surface - Difficult to remove
    - Increase drug from skin, hair or
    absorption clothing
    - Occlusive (resistant to - Doesn’t cause a cold
    water) sensation because it is not
    - Usually doesn’t contain evaporated
    preservatives, thereby - Uncomfortable to use in
    reducing the risk of warm weather
    sensitization
    • A semisolid dosage form
    consisting no less than 60%
    of water and containing one
    or more drug substances
    dissolved or dispersed in a
    suitable base and are mostly
    used for cosmetic purposes.
    They can also be used to treat
    allergies, rashes or any other
    skin problems.
    CREAM
    Oil Phase

    Water Phase
    - Moisturizing and contains - Doesn’t provide hydration
    emollient ingredients as well as ointment, thereby
    - Easier to apply and has a reducing drug absorption
    wider spread than ointment - Preservatives such as
    - Less sticky than ointment parabens can cause irritation
    in some people
    - Easy to clean from skin,
    hair and clothing
    - Evaporation occurs on the
    skin, resulting in a cooling
    effect
    • Pastes are semisolid
    dosage forms
    containing a high
    percentage (50% or
    more) of insoluble
    solids dispersed in a
    suitable base.
    PASTE
    Solid Ingredients

    Paste Base
    - Protects the skin from - Uncomfortable to use in large
    external irritation areas
    - Sticks firmly to the skin - Difficult to remove from
    (longer contact time) skin, hair or clothing
    - Limit the drug to only the
    area applied
    - The high solid ingredient
    content can attract water to the
    surface of the skin, thereby
    reducing swelling in the skin
    • Gels are semisolid dosage
    forms used to deliver drugs.
    Gels contain a gelling
    agent that is dispersed in
    water, producing a jelly-
    like consistency. Common
    gelling agents include
    polymers, natural gums,
    and cellulose derivatives.
    GEL
    Gelling Agent
    - Non-greasy - The hydration ability is
    - Can be easily cleaned lower than creams and
    from skin, hair and clothing ointments so drug
    absorption is lower
    - There is a cold sensation
    due to evaporation, thereby - Preservatives can cause
    reducing pain and itching irritation in some people
    - If it contains alcohol, it
    can cause a burning
    sensation and dry skin
    - Susceptible to
    contamination
    CONCL The choice of topical
    preparation needs to consider
    USION several things, such as the
    type of skin lesion, location
    of the lesion, and patient
    preferences. Appropriate
    selection will increase drug
    penetration in the body and
    maintain patient compliance
    in using the drug.
    THANK
    YOU

    IRSAN JAYA

    You might also like