Presentation 3

Tubular reabsorption
 Tubular reabsorption is the process by which water and other

substances are transported from renal tubules back to the
blood after filtration
• Essential substances such as glucose, amino acids and

vitamins are completely reabsorbed from renal to the blood .
 MECHANISM OF REABSORPTION
Basic transport mechanisms involved in tubular reabsorption
are of two types:
1. Active reabsorption
2. Passive reabsorption.
 Active reabsorption
is the movement of molecules against the electrochemical
gradient. It needs liberation of energy, which is derived from
ATP.
Substances reabsorbed actively from the renal tubule are
sodium, calcium, potassium, phosphates, sulfates,
bicarbonates, glucose, amino acids, ascorbic acid, uric acid
and ketone bodies.
 Passive Reabsorption
Passive reabsorption is the movement of molecules along the
electrochemical gradient. This process does not need energy.
Substances reabsorbed passively are chloride, urea and
water.
 ROUTES OF REABSORPTION
Reabsorption of substances from tubular lumen into the

peritubular capillary occurs by two routes:
1. transcelllular route
2. paracellular route
• 1.Trancelluar route
• the substances move
through the cell.
• It includes transport of
substances from:
① Tubular lumen into

tubular cell through
apical (luminal) surface
of the cell membrane
② Tubular cell into
interstitial fluid
③ Interstitial fluid into
capillary.
• 2. Paracellular route
• the substances move
through the intercellular
space.
• It includes transport of
substances from:
① Tubular lumen into

interstitial fluid present in
lateral intercellular space
through the tight
② junction between the
cells
③ Interstitial fluid into
capillary
Site of Reabsorption
• substances
reabsorpted from the
proximal convoluted
tubule are glucose,
proteins ,vitamins
amino acids, sodium,
potassium, calcium,
bicarbonates,
chlorides,
phosphates, urea,
uric acid and water.
• Substances reabsorbed
from loop of Henle are
water, potasium ,sodium
and chloride.
• Substances Reabsorbed
from Distal Convoluted
Tubule are Sodium,
coloride, bicarbonate and
water
TUBULAR REABSORPTION OF SODIUM
• 1kg NaCl is filtered daily

• all the segments of the nephron participate in Na reabsorption (except
the descending limb of the loop of Henle)
• Na reabsorption by diffusion ( along an electrochemical gradient), by
symport with glucose and counter transport with H
• from cells Na is pumped into the interstitial space (via Na-K-pump)
Cl anions follow Na movement
65% of filtered Na is reabsorbed at the PCT (along with diffusion of H ₂O

from the interstitial space to the vessel)
• 25% of filtered Na is reabsorbed at the ascending limb of the loop of
Henle
• 8-10% of filtered Na is reabsorbed at the DCT and CD
Glucose reabsorption
Glucose is completely reabsorbed in the proximal
convoluted tubule. It is transported by secondary active
transport (sodium cotransport) mechanism.
Glucose and sodium bind to a common carrier protein in
the luminal membrane of tubular epithelium and enter the
cell. The carrier protein is called sodium-dependant
glucose cotransporter 2 (SGLT2).
From tubular cell glucose is transported into medullary
interstitium by another carrier protein called glucose
transporter 2 (GLUT2).
Reabsorption of Amino Acids
Amino acids are also reabsorbed completely in proximal
convoluted tubule. Amino acids are reabsorbed actively by
the secondary active transport mechanism along with
sodium.
Hormone Action
 Aldosterone: Increases sodium reabsorption in
ascending limb, distal convoluted tubule and
collecting duct
 Angiotensin II: Increases sodium reabsorption in
proximal tubule, thick ascending limb, distal tubule
and collecting duct (mainly in proximal convoluted
tubule)
 Antidiuretic hormone: Increases water reabsorption
in distal convoluted tubule and collecting duct
 Parathormone :Increases reabsorption of
calcium,magnesium and hydrogen Decreases
phosphate reabsorption
 Calcitonin :Decreases calcium reabsorption

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Tubular reabsorption

 Tubular reabsorption is the process by which water and other

• Essential substances such as glucose, amino acids and

Reabsorption of substances from tubular lumen into the

① Tubular lumen into

① Tubular lumen into

• 1kg NaCl is filtered daily

65% of filtered Na is reabsorbed at the PCT (along with diffusion of H ₂O

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