Tumors of Eyelids

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TUMORS OF

EYELIDS
CLASSIFICATION OF TUMORS

Tumors of eyelids are broadly classified into two


categories;

• Non-Pigmented Tumors
• Pigmented Tumors
NON-PIGMENTED TUMORS

Non-Pigmented tumors are further classified into two


subtypes;

• Benign Tumors
• Malignant Tumors
MALIGNANT TUMORS

Malignant tumors are cancerous and can spread


cancer cells throughout one’s body through the blood
or lymphatic system, a process known as metastasis.

• Basal Cell Carcinoma


• Squamous Cell Carcinoma
• Sebaceous Gland Carcinoma
• Merkel Cell Carcinoma
• Kaposi Sarcoma
BASAL CELL CARCINOMA

• Arises from basal layer of epidermis


• Affects elderly people
• Most common malignancy, almost 90% of cases
• Arises from lower eyelid, followed by medial
canthus, upper eyelid and lateral canthus
• Slowly growing, locally invasive, non-metastasizing
• Tumor near medial canthus likely to invade orbit
RISK FACTORS

• Increasing age
• Extended sun exposure in fat-skinned people
• Cutaneous disease
CLINICAL TYPES

• Nodular
Most common, shiny, firm pearly indurated nodule
with blood vessels on its surface
• Nodulo-Ulcerative
Nodule has central ulceration, pearly raised rolled
edges with fine blood vessels over the lateral margins
CLINICAL TYPES

• Sclerosing and Infiltrative


Flat, indurated plaque due to infiltration occurring
under epidermis.
Tends to be more aggressive on palpation than on
inspection.
It stimulates chronic blepharitis
TREATMENT

• Incisional Biopsy
• Excisional Biopsy
• Cryotherapy
• Radiation Therapy
• Laser Microsurgery
• Chemotherapy
• Topical Imiquimod 5% Cream.
SQUAMOUS CELL CARCINOMA

• Arises from cell layer of epidermis


• Second most common eyelid malignancy, 5-10% of
the cases
• Most common in older fair-skinned people with a
history of chronic sun exposure
• Arises de novo / from pre-existing actinic keratosis /
carcinoma in situ (Bowen’s Disease)
• Metastasis to regional lymph nodes
RISK FACTORS

• Increasing age
• Extended sun exposure
• White skin
• Immune suppression
• Xeroderma pigmentosa
CLINICAL TYPES

• Bowen’s Disease
SCC in situ, roughened scaly erythematous
hyperkeratotic, sharply demarcated patch/plaque
• Nodular
Appears as hyperkeratotic nodule
• Ulcerative
Ulcer have red base with sharply defined indurated
and everted borders
TREATMENT

• Exenteration
• Excisional Surgery
• Radiation Therapy
SEBACEOUS GLAND CARCINOMA

• Arises from Meibomian glands, also from glands of


Zeis
• Average age is 60 years
• Incidence is almost 1%
• Most commonly occurs in upper eyelids
RISK FACTORS

• Increasing age
• Common in Asians
• Immune suppression
• Xeroderma pigmentosa
CLINICAL TYPES

• Nodular
Appears as discrete painless nodule.
Stimulates chalazion
• Spreading
Appears as diffuse thickening of eyelid due to
infiltration into the dermis
Stimulates chronic blepharitis
TREATMENT

• Exenteration
• Excisional Surgery
• Radiation Therapy
MERKEL CELL CARCINOMA

• Very rare tumor of eyelid seen in older age people


• Rapidly growing, highly malignant tumor
• Arises from Merkel cells which are epithelial
neuroendocrine cells
• CLINICALLY
Appears violaceous, well-demarcated defined nodule
with intact overlying skin
• TREATMENT
Excisional Surgery
KAPOSI SARCOMA

• Rare tumor arising from human herpesvirus 8


(HHV8)
• Usually affects people with AIDS
• CLINICALLY
It is vascular tumor appearing pink, red-violet to
brown lesion
• TREATMENT
Radiotherapy or Excision with optimal control of AIDS
THANK
YOU!

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