Pelvic Inflammatory Disease

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Pelvic

inflammatory
Disease
Definition
Pelvic inflammatory disease (PID) is an infection-related
inflammation of the upper vaginal tract in women. The
uterus, Fallopian tubes, and/or ovaries are all affected by
the condition. It is usually an ascending infection that
01. begins in the lower genital tract and spreads upward.

PID can affect anyone but sexually active women in their


20s are at higher risk of being affected.

PID is treatable, however if left untreated it can cause


severe damage to the reproductive system, infertility or
ectopic pregnancy
Etiology
Sexually transmitted infections (STIs)are the most prevalent cause of PID
• Chlamydia
• Gonnerhea
• Mycoplasma genitalium
Other probable causes of PID
• Ruptured appendix
• Bowel infection (such as gastroenteritis)
• Vaginal infection (such as bacterial vaginosis or BV)
• some surgical procedures (such as dilatation and curettage (D&C),
insertion of an intrauterine device (IUD) or surgical abortion).
Clinical manifestations
The medical and sexual history, as well as a gynecological examination, are used to determine
the signs and symptoms of pelvic inflammatory disease. While it is possible to be
asymptomatic, symptoms include:

• Lower abdominal discomfort


• Deep dyspareunia (painful sexual activity)
• Menstrual irregularities (for example, menorrhagia, dysmenorrhea, or intermenstrual
hemorrhage)
• Bleeding after a sexual encounter
• Painful urination (dysuria)
• Abnormal vaginal discharge (particularly if purulent or odorous)

Women with advanced instances may feel severe lower abdomen discomfort fever (>38° C),
nausea, and vomiting. Tenderness of the uterus/adnexal or cervical excitement (on bimanual
palpation) may be detected during a vaginal examination. There might be a palpable bulge in
the lower abdomen, as well as an irregular vaginal discharge.
Pathophysiology
1. Sexually transmitted pathogens such as Chlamydia trachomatis
or Neisseria gonorrhoeae infect the cervix.
The vaginal flora in healthy females contains various potentially harmful
bacteria, including Prevotella, Leptotrichia, Atopobium, and anaerobes.
These bacteria exist in low numbers and can fluctuate due to factors like
hormones, contraceptives, sexual activity, and hygiene practices.
2. The pathogens disrupt the barrier provided by the endocervical
canal.
The endocervical canal(passageway from inside the uterus to the vagina)
acts as a barrier, protecting the upper genital tract from vaginal bacteria.
Infection with sexually transmitted pathogens can disrupt this barrier.
3. Vaginal bacteria gain access to the upper genital organs.
When the barrier is disrupted, vaginal bacteria can enter the upper genital organs,
starting with the endometrium, then progressing to the endosalpinx(mucous
membrane of the fallopian tube), ovaries, pelvic peritoneum, and underlying
stroma.
4. Ascending Infection
Once the cervical barrier is compromised, bacteria can ascend into the upper
genital organs. This typically starts with the endometrium (lining of the uterus) and
can progress to involve the fallopian tubes, ovaries, pelvic peritoneum, and
underlying tissues.
5. Inflammatory Response
As the bacteria ascend, they induce an inflammatory response. This leads to
redness, swelling, and increased blood flow in the affected tissues.
6. Specific Infections
Endometritis: Infection of the endometrium. This can lead to symptoms like
pelvic pain, abnormal bleeding, and fever.
Salpingitis: Infection of the fallopian tubes. This is a crucial step, as it can lead
to complications like tubal scarring, blockage, and ectopic pregnancy.
Oophoritis: Infection of the ovaries. This can cause localized pain and
tenderness.
Imaging modalities
Ultrasound – modality of choice
The transabdominal approach best demonstrates the extent of the disease process, whereas the endovaginal
approach is most sensitive for detecting dilated tubes, inflammatory changes, and abscesses. The fluid-filled
urinary bladder provides an excellent acoustic window by displacing confusing loops of small bowel. Ultrasound
demonstrates a thickened endometrium, possibly with irregularity that may contain fluid.
CT
may aid in assessing the full extent of the disease
MRI
unnecessary unless the patient has an iodine allergy
Planar Radiography
Plain abdominal or pelvic radiographs are of little value in detecting PID and pelvic abscesses. Abnormal gas
collections can be masked by fecal material in the rectum and in loops of small bowel
HGS
This test should not be performed if you have pelvic inflammatory disease (PID) or have unexplained vaginal
bleeding.
Imaging appearance
. Endometritis. Ultrasound image illustrates an
enlarged endometrial cavity with a heterogeneous
echogenicity (between cursors) associated with a
therapeutic abortion

Tubo-ovarian abscess. Ultrasound image


demonstrates a large sonolucent mass (M)
posterior to the bladder (B)
Transabdominal ultrasound scan. This image demonstrates
an echogenic region within the endometrium with dirty
shadowing, a finding that is compatible with air in the
endometrium and endometritis. Additionally, bilateral
complex masses are present; this finding is compatible with
tubo-ovarian masses.

Endovaginal ultrasound scan. This image shows a relatively


enlarged right ovary in a patient who had pain, increased
flow, and a small amount of adjacent free fluid. These
findings are compatible with oophoritis.
Chronic pelvic inflammatory disease. Transverse sonogram
demonstrates large, complex cystic and echogenic masses
(arrows) posterior to the echo-free bladder
CT
Fluid in the endometrial cavity with pelvic fat
stranding suggestive of endometritis

Tubo-ovarian abscesses with inflammation extending


along the right paracolic gutter up to the subhepatic
region and presenting with right upper quadrant pain
Loculated complex cystic lesion in the mid pelvis with folds and thick wall
enhancement suggestive of pyosalpinx
References

Endosalpinx | definition of endosalpinx by Medical dictionary (thefreedictionary.com)


Pelvic inflammatry disease: Pathogenesis, microbiology, and risk factors - UpToDate
2017 European guideline for the management of pelvic inflammatory disease - PubMed
(nih.gov)

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