Cell Organels and Function

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CELL STRUCTURE AND

FUNCTION

Ni Nyoman Ayu Dewi


Dept. of Biochemistry
Faculty of Medicine Udayana University
http://www.encognitive.com
Characteristic Prokaryotic Eukaryotic
http://facinatingamazinganimals.wordpress.com http://www.mhhe.com
www.stiffneck.org
NUCLEUS
CENTRAL DOGMA
DNA REPLICATION

DNA
TRANSCRIPTION

REVERSE TRANSCRIPTION

RNA TRANSLATION PROTEIN

RNA REPLICATION
www.tokresource.org
RIBOSOMES

http://hyperphysics.phy-astr.gsu.edu

http://ridge.icu.ac.jp/biobk/BioBookCELL2.html
RIBOSOMES
 Can be found in both prokaryotes and eukaryotes
 Eukaryotic ribosomes are slightly larger than
prokaryotic ones
 Structurally consist of a small and larger subunit
 Biochemically consist of ribosomal RNA (rRNA) and
some 50 structural proteins
 Free ribosomes or as a cluster on the 
endoplasmic reticulum
 Catalyze the synthesis of protein
ENDOPLASMIC RETICULUM

http://micro.magnet.fsu.edu
ENDOPLASMIC RETICULUM
 Smooth and rough ER
 Forms the outer bilayer of the nuclear
envelope
 Protein processing and lipid biosynthesis
 Regulate the cytoplasmic Ca2+
concentration
 Very dynamic; continuous bidirectional
traffic between ER and Golgi apparatus
GOLGI APPARATUS

http://jc-biology.blogspot.com/20
11/02/structure-and-functions-of
-organelles.html
PROTEIN TARGETING

http://bass.bio.uci.edu
http://www.fastbleep.com
MITOCHONDRIA
• Primary role: to produce
90% energy (ATP) via
oxidative
phosphorylation.
• Mitochondrial
dysfunction  defect on
oxidative
phosphorylation, usually
coincides with the
occurrence of excess
Reactive Oxygen Species
(ROS) production
oxidative stress
MITOCHONDRIA
LYSOSOMES

http://micro.magnet.fsu.edu/cells/lysosomes/lysosomes.html
LYSOSOMES

http://www.biology4kids.com/files/cell_lysosome.html

http://bioserv.fiu.edu
PEROXISOMES

http://micro.magnet.fsu.edu/cells/peroxisomes/peroxisomes.html
Lysosome and Peroxisome

Characteristics of lysosomes: Characteristics of peroxisomes:


 fuses with food vacuoles  not a part of the
and membranous vesicles endomembrane system
 contains hydrolytic  break down substances via
enzymes for digestion oxidation
 digests macromolecules  detoxify
 breaks down damaged  break down fatty acids
organelles  built with proteins from
 built with proteins from ribosomes in the cytosol
the rough ER

Campbell, Neil and Jane Reece, Lisa Urry et al. Biology, 8th ed.
Pearson Education. 2008.
CYTOSKELETON
Microfilaments
solid protein (actin) which is assembled at
one end and disassembled at the other end
maintain cell shape by resisting tension (pull)
used in cell division
muscle contraction

Intermediate filaments - rope-like fibrous


proteins
provide structural reinforcement by resisting
tension (pull)
anchor organelles
keep nucleus in place

Microtubules - hollow tubes of tubulin (a globular


protein)
maintains cell shape by resisting compression
(push)
anchor organelles
movement of organelles
track for motor proteins
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