Course Code: MPHT1002 Course Name: Drug Delivery System

School of Medical And Allied Sciences
Course Code : MPHT1002 Course Name: Drug delivery system
Module 3:
Lecture 6:
Buccal drug delivery system
Name of the Faculty: Prof. P.K Sharma Program Name: M.Pharm

Disclaimer
• All the content material provided here is only for

teaching purpose.
Objective:
To study the concept of buccal drug delivery system?

To understand the uses pathways of buccal drug delivery
system?
Buccal Dosage forms
There are various types of buccal dosage forms are

available but mainly:-
1. Buccal Tablets
2. Buccal patches/ Films
3. Buccal gel/ Ointment
Buccal tablet
Buccal patch/Films
Buccal Gel/Ointment
Vedio presentation
Mucoadhesion
Mucoadhesive are synthetic or natural polymers which

interact with the mucus layer covering the mucosal
epithelial surface and mucin molecules constituting a
major part of mucus.
Two surfaces are held together by interfacial forces
which may consist of valence forces, inter locking action or
both.
Mucoadhesive drug delivery system utilize the property
of bio adhesion of certain water-soluble polymers which
become adhesive on hydration.
If adhesive attachment is to a mucous coat the
phenomenon is known as mucoadhesion.
Example of Mucoadhesive Polymer
Natural polymers : Chitosan, Xanthum gum,

Pectin and Alginates
Synthetic polymers :
1. Polyacrylic acid derivatives:- Carbopol,
Polycarbophil, Polyacrylate
2. Cellulose derivatives :- Carboxy methyl
cellulose, HPMC, Methyl cellulose, Methyl
hydroxy ethyl cellulose
History of Mucoadhesion
Since the early 1980,the concept of Mucoadhesion

has gained considerable interest in pharmaceutical
technology.
MDDS have been developed for buccal ,nasal,
rectal & vaginal routes for both systemic & local
effects.
MDDS is the best choice for hydrophilic high mol.
wt. substance such as peptides that cannot be
administered & which has poor absorption.
History of Mucoadhesion
Anatomy of Buccal Mucosa
Buccal mucosa lines the inner region of cheeks.
It has mainly two parts & is 500-800um thick &

150Cm sqare approx.
The oral mucosa is divided as

1. Epithelium
2. Basement membrane and connective tissues
Epithelium
1. Epithelium
 The oral epithelium of the mouth consists of 40-
50 layers Stratified & Squamous epithelial cell,
having thickness of 500-800 µm, which can be
keratinized, or non-keratinized.
 Keratinized epithelium is dehydrated,
mechanically tough and chemically resistant. It is
found in areas of the oral cavity subject to
mechanical stress such as the mucosa of the
gingiva ( gums ) and hard palate ( roof of mouth )
Epithelium
Non-keratinized epithelium is relatively flexible

and is found in areas such as the soft palate, the
floor of the mouth, the lips and the cheeks.
Thus the regions of the oral cavity pertinent to

drug delivery (i.e. the sublingual and buccal regions)
have a non-keratinized epithelium.
Basement membrane and connective tissue
2. Basement membrane and connective tissue

The basement membrane is a continuous layer of
extracellular materials and form a boundary
between the basal layer of epithelium and the
connective tissues.
This basal complex anchors the epithelium to the
connective tissue and supplements to the barrier
functions of the superficial layers of the epithelium
to prevent some large molecules from passing the
oral mucosa
Basement membrane and connective tissue
The bulk of connective tissue consists of a

collagen fibre network, this organization of which
determines mechanical stability, resistance to
deformation and extendibility of the tissue.
Most likely, the connective tissue, along with the
basement membrane, is not consider to influence
the diffusion of most compounds of
pharmacological interest although this two regions
may limit the movement of some macro molecules
and complexes.
Structure of buccal mucosa
Summary
Buccal drug delivery is a promising area for

systemic delivery of orally inefficient drugs as
well as an attractive alternative for noninvasive
delivery of potent peptide and perhaps protein
drug molecules
References
Doshi S.M., Tank H.M., Gastro Retention – An

Innovation over Conventional poorly Soluble Drugs : A
review, International Journal of Pharmaceutical and
chemcal Sciences, 2012;1(2):859-866.
S. P. Vyas, Roop K. Khar, CONTROLLED DRUG
DELIVERY – Concepts & Advances, Vallabh Prakashan,
page no. 196-217.
N. K. Jain, Progress in Controlled & Novel Drug Delivery
Systems, 1st edition 2004, CBS Publishers, page no.76-97
Chien Yie W. “ Novel drug delivery systems”, Vol-50, 2nd
ed, Marcel Dekker . Inc, New York. Pg No.164-177.

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School of Medical And Allied Sciences

Course Code : MPHT1002 Course Name: Drug delivery system

Name of the Faculty: Prof. P.K Sharma Program Name: M.Pharm

• All the content material provided here is only for

To study the concept of buccal drug delivery system?

There are various types of buccal dosage forms are

Mucoadhesive are synthetic or natural polymers which

Natural polymers : Chitosan, Xanthum gum,

Since the early 1980,the concept of Mucoadhesion

Buccal mucosa lines the inner region of cheeks.

It has mainly two parts & is 500-800um thick &

The oral mucosa is divided as

Non-keratinized epithelium is relatively flexible

Thus the regions of the oral cavity pertinent to

2. Basement membrane and connective tissue

The bulk of connective tissue consists of a

Buccal drug delivery is a promising area for

Doshi S.M., Tank H.M., Gastro Retention – An

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