Bioterrorism

Bioterrorism:ICS
Dr. Pendru Raghunath

1. Which of the following microorganisms is the
etiologic agent for plague?
A. Bacillus anthracis
B. Yersinia pestis
C. Chlamydia psittaci
D. Escherichia coli
2. Which of the following is associated with
infant botulism?
A. Black-tar heroin
B. Fermented food
C. Honey ingestion
D. Lactation
3. Psittacosis belongs to which bioterrorism
agent category?
A. Category A
B. Category B
C. Category C
D. Category D
4. Which of the following is the drug of choice for
the treatment of plague?
A. Ampicillin/sulbactam
B. Ceftriaxone
C. Ritonavir
D. Streptomycin
5. Which of the following is the drug of choice for
the treatment of cutaneous anthrax?
A. Ciprofloxacin
B. Clindamycin
C. Erythromycin
D. Oxacillin
6. Which of the following is the most common
complication of tularemia?
A. Cranial nerve paralysis
B. Lymph node suppuration
C. Liver failure
D. Headache
7. Which of the following is classified as a
Category C emerging infectious disease threat?
A. Ebola virus
B. Smallpox
C. Hantavirus
D. Viral encephalitis
8. Which of the following is TRUE regarding
botulism treatment?
A. There is a vaccine available for prevention of
the disease.
B. Ciprofloxacin is the drug of choice
C. Heptavalent botulinum antitoxin is available for
the treatment of infant.
D. Supportive care remains the mainstay of
botulism treatment
9. Which of the following microorganisms forms
spores in the presence of oxygen?
A. Yersinia pestis
B. Bacillus anthracis
C. Francisella tularensis
D. Clostridium botulinum
10. A scrapping from a painful, inflamed wound is found to
contain numerous Gram-negative bacteria. Upon questioning,
the feverish patient states that a cat, while trying to rescue it
from a tree earlier in the day, bit him. Given these observations,
which of the following Gram-negative bacteria is the most likely
cause of infection?
A. Acinetobacter baumannii
B. Campylobacter jejuni
C. Pasteurella multocida
D. Pseudomonas aeruginosa
E. Yersinia enterocolitica
11. A man in his early 50s comes in with a complaint of fever, chills,
malaise and fatigue for the past two days. The physician examines him
and takes a history. The only clinical finding is a necrotic ulcer about the
size of a quarter on his right thumb. Axillary lymph nodes are swollen and
tender. The man said he cut himself while skinning an animal five days
ago. On the basis of these observations, the physician prescribes
streptomycin and asks the man to call if his symptoms do not improve in
three days. On the basis of the limited information above, the physician
has obviously made a diagnosis. What is it?
A. Plague caused by Yersinia pestis
B. Brucellosis caused by Brucella melitensis
C. Pasteurellosis caused by Pasteurella multocida
D. Tularemia caused by Francisella tularensis
E. Pertusis caused by Bordetella pertussis
12. Which of the following bacteria is part of the
normal nasopharyngeal flora of domestic cats/
dogs and can cause an abscess, cellulitis and
osteomyelitis?
A. Pasteurella multocida
B. Brucella abortus
C. Yersinia enterocolitica
D. Francisella tularensi
E. Shigella flexneri
13. This granulomatous infection invades the
reticulo-endothelial cells of the lymph nodes, liver,
spleen and bone marrow.
A. Pasteurellosis
B. Tularemia
C. Plague
D. Cat-scratch disease
E. Brucellosis
14. A 34-year-old male presented with a 6-week history of acute, intractable
lower back and right leg pain. A series of tests were performed and the patient
was admitted for surgery of a herniated disk. A biopsy was sent for pathology and
culture. The tissue showed granulomatous inflammation and scattered giant cells
were found. Cultures of the biopsy grew Gram-negative coccobacilli. When the
organism was identify (Brucella sp.), a more extensive social and travel history
was elicited. It was learned that 5 months earlier he had visited family in Mexico.
During his visit, both his mother and a brother had a febrile illness. He also
admitted to consuming goat milk and cheese from his father-in law who raised
goats. Which Brucella specie is causing the infection?
A. Brucella suis
B. Brucella melitensis
C. Brucella abortus
D. Brucella canis
E. Brucella ovis
15. Brucella sp. are typically found in organs of the
reticuleendothelial system (RES). The localization
of brucellae in the RES is due to the ability of this
organism to:
A. produce powerful toxins
B. resist antimicrobial therapy
C. mimic host tissues
D. bind to cell surfaces
E. survive inside macrophage
16. What is the cardinal manifestation of human
brucellosis?
A. Vomiting and diarrhea
B. A pseudomembrane in the throat
C. A fluctuating pattern of fever
D. Peeling of the skin on the palms and soles
E. A cough that lasts for months
17. A patient presents with headache, chills, coughing and
signs of a systemic infection. The patient mentions
recently returning from a trip to Arizona after a week at a
black-footed prairie dog retreat. What is the likely
infectious agent?
A. Yersinia pestis
B. Pasteurella multocida
C. Leptospira interrogans
D. Francisella tularensis
E. Shigella flexneri
18. Which of the following organisms has the F1,
V, and W virulence factors that allow it to resist
destruction after phagocytosis?
A. Pasteurella multocida
B. Brucella abortus
C. Yersinia pestis
D. Francisella tularensi
E. Bartonella henselae

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Bioterrorism:ICS

Dr. Pendru Raghunath

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