Curs 12 - AVC Hemoragic

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Hemoragiile cerebrale

• 15% din bolile vasculare cerebrale

• Def: suferinta cerebrala datorata efractiei


unui vas - extravazarea sangelui in:
– parenchimul cerebral = hemoragie
intraparenchimatoasa
– extracerebral = hemoragie subarahnoidiana
Hemoragia intraparenchimatoasa
(hemoragia cerebrala, apoplexia)
• > 10% din AVC; 12-15/100.000
• rata decese ~ 50%

• Factori de risc:
• varsta peste 55 ani, sex M
• consumul de alcool, droguri
Factori de risc medicali
• HTA
• malformatii vasculare
• amiloidoza cerebrala
• iatrogen: antitrombotice, simpatomimetice
• coagulopatii
• leucoze
• tumori
Topografie
• Profunda: HTA - • Lobara:
stress hemodinamic
amiloidoza
– ganglioni bazali
– talamus malformatii vasculare
– punte toxice (alcool)
– cerebel
• Fara predilectie:
coagulopatii
tumori
Diagnostic clinic
• Debut brusc (in activitate), agravare progresiva
(ore)
• cefalee intensa +/- varsaturi
• salt tensional (> AVC ischemic)
• alterarea starii constienta - coma
• deficit neurologic focal coresp topografiei:
hemiplegie, paralizii nn cranieni, tulb
sensibilitate, coordonare
Diagnostic paraclinic
• CT urgenta / IRM
• dg etiologic
Complicatii
• Resangerare
• efractie ventriculara - hidrocefalie acuta
obstructiva
• Efractie subarahnoidiana
• edem cerebral

• complicatii generale: infectii, tromboze


venoase, tulburari cardiace
Herniile cerebrale
Transtentoriala
Amigdaliana
Tratament
• Medical:
– factor VIIa recombinat activat (NovoSeven) -
abandonat
– antiedematoase
– TAS < 180 mmHg
– trat etiologic (tulb coagulare)
• Chirurgical (+/-):
– evacuare: superficiale, risc letal (dimens, poz), tumori
– drenaj ventricular
– decompresie (si in AVC ischemice)
Hemoragia subarahnoidiana
Etiologie

• Anevrisme intracraniene (75%)


• traumatisme
• disectii arteriale
• coagulopatii
• vasculite
Diagnostic clinic
• Debut brusc, agravare progresiva
• salt tensional
• Sindrom meningeal
– cefalee, varsaturi, fotofobie
– semne meningeale: redoare de ceafa, Kernig,
Brudzinschi
• alterarea starii de constienta
• semne neurologice de focar
Scala Hunt si Hess
• 1. Asimptomatic / usoara rigiditate ceafa
• 2. Paralizii nn cranieni, redoare ceafa
• 3. Deficit focal minor, somnolenta/confuzie
• 4. Deficit focal moderat/sever, stupor,
rigiditate decerebrata incipienta
• 5. Coma profunda, rigiditate decerebrata
Diagnostic paraclinic

• CT
• punctie lombara
• angiografie (I 72 h)
Complicatii
• Resangerare - max z 1, 14
• Hidrocefalia normotensiva
• vasospasm - z 3-10 => deficit focal (infarct)
• hiponatremia - pierdere cerebrala de Na
• tulburari vegetative (cardiace:tulb ritm,
conducere)
Tratament
• Chirurgical: Z 1-3 sau > 14
– Hunt si Hess 1-3
• Medical:
– Preventia vasospasm:
• blocanti C Ca: nimodipina
• Hiperhidratare (?) – nou: discutabil
– supliment Na (corector)
– controlul TA
– antiedematoase, simptomatice (durere!)
Sistemul venos
Tromboza venoasa cerebrala
Etiologie
• Focar infectios de vecinatate
• Traumatism
• Coagulopatii
• Iatrogen
• Sarcina
• Neoplazii
Clinic
• Cefalee
• Sindrom meningeal
• Crize epileptice
• Semne neurologice de focar
– Ocluzie venoasa
– Infarct venos
– Transformare hemoragica
Paraclinic
• Ct cerebral
urgenta
• MRI – angio timp
venos
• Angiografie

• Profil coagulare
• Focarul infectios
Diagnostic diferential
• Meningite, meningoencefalite
• HSA
• AVC ischemic / hemoragic

• Tumori
• Abcese
Tratament

• Anticoagulant:
heparina fractionata ->
standard
• Corticoterapie + Ab
• Simptomatic:
antialgic, antiepileptic
• Tromboliza,
trombectomie,
decompresie

• Anticoagulant cronic:
– Fara factori risc: 3-6
l
– Neprecizat: 6-12 l
– Trombofilie:
nedefinit
Evolutie
• Forme usoare: remisiune
spontana
• Forme medii: raspund la
terapie, remisiune completa
• Forme severe: sinusuri
profunde, infarcte masive
hemoragice – deces (10%)

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