Emergency Drugs
Emergency Drugs
Emergency Drugs
DRUGS
Epinephrine
Indication
VF, pulseless VT, or asystole
1 mg I.V push every 3-5 min
Intermediate dosing: 2-5 mg IV push over 3-5 min
Escalating dosing: 1mg, 3mg, 5 mg IV push 3 min apart
High dosing: ,1 mg/kg IV push every 3 – 5 min
Symptomatic Bradycardia: continous infusion at 2-10 mcg/min;
titrate to hemodynamic response
Nsg. consideration
Each dose is followed by 20 mL iv fluid flush.
Can be given via ET tube 2-2.5 x the IV dose, followed
with 10 mL Flush PNSS
IC when no other route is available
It increases systemic vascular resistance, BP, Cardiac
elec. Activity, strenth of contraction, automaticity, and
myocardial O2 requirement
Lidocaine
Indication
VF or Pulseless VT: Initially 1-1.5 mg/kg IV push:
every 3-5 mins, max of 3mg/kg
Stable VT or Stable wide-complex tachycardia:
repeat doses half the original dose.
If lidocaine succesfully converts the VF/VT: begin
continous infusion at 2-4 mg/min
Nsg consideration
Toxicity( Slurred speech, altertered LOC, Muscle
twitching, and seizures), stop the drug/reduce dose
Via ET: 2-2.5 times the iv dose, flush with 10 ml PNSS
Don’t give if PVC occurs with bradycardia or escape
rhythm.
No longer recommended for VT/VF prophylaxis in
acute MI
Atropine
Symptomatic Bradycardia
.5-1 mg iv push q 3-5 min, not to exceed .04 mg/kg
Asystole
1 mg iv push q 3-5 min, not to exceed a total dose of .
04mg/kg
Nsg consideration
Don’t give less than .5 mg dose – may further slow
heart rate
Via ET: dilute 1-2 mg in 10 mL sterile water of PNSS,
flush with 10 mL PNSS
Adenosine
wide-complex tachycardia:
Initially 6 mg rapid iv push; if no response in 1-2 min,
give 12 mg iv push; may be followed by a third 12 mg
dose given in 1-2 min.
Nsg consideration
Given rapidly over 1-3 sec
Follow dose with a 20 ml PNSS flush
If methylxanthines, dipyridamole and carbamazepine
are present higher dose may be needed
A brief period of Asystole is common after
administration
Bretylium
VF/ pulseless VT unresponsive to defibrilation, epi and
lido
5mg/kg iv push; if arhythmia persists, increase to 10
mg/kg q 5-10 min, to a max dose of 35 mg/kg
Stable VT or Stable wide-complex tachycardia:
5-10 mg/kg over 8-10 min, to max 35 mg/kg over 24 hrs,
if loading dose converts arhythmia start infusion of 2
mg/min.
Dobutamine
Heart Failure
2-20 mcg/kg/min
Nsg considerations
May cause tachycardia and other arhythmias, BP
fluctuations, nausea and hypokalemia
Monitor heart closely; increases in heart heart rate
more than 10% may induce or exacerbate Myocardial
Ischemia
Dopamine
Hypotension with symptomatic bradycardia, heart
failure or after spontaneous return of circulation
Initially, 1-5 mcg/kg/min; max is 20 mcg/kg/min
Enhances renal blood flow – 1-2 mcg/kg/min
Nsg consideration
May induce tachycardia, - dose reduction/withdrawal
Extravasation may cause severe tissue necrosis
Norepinephrine should be added is more than max
dose is needed to maintain BP
Use slowest infusion first
Can exacerbate pulmonary congestion and
compromise cardiac output
Eliminate hypovolemia as a cause of hypotension
before treating
Magnesium
VF/VT with hypomagnesemia
1-2 grams diluted in 10 mL D5W given IV push over 1-2
min
Torsades de pointes: 5-10 grams iv
Acute MI with hypomagnesemia
Intermitent of continous infusions
Nsg consideration
Flushing, sweating, mild bradycardia, and
hypotension may develop from rapid administration in
non arrest situations
Procainamide
PVCs or recurrent VT with pulse
Initially, 20 mg/min until
Hypotension occurs
QRS complex
PR interval
QT interval is widened by 50 %
Total of 17mg/kg of the drug was administered
Maintenance infusion 1-4 mg/min
Nsg consideration
Monitor BP closely during administration; may cause
precipitous hypotension, infuse cautiously in patients
with acute MI
Contraindicated in patients with preexisting long QT
intervals and torsades de pointes
Torsades de pointes, or simply torsades is a French
term that literally means "twisting of the points". It was
first described by Dessertenne in 1966 and refers to a
specific, rare variety of ventricular tachycardia that
exhibits distinct characteristics on the electrocardiogram
(ECG).
Characteristics
Rotation of the heart's electrical axis by at least 180º
Prolonged QT interval (LQTS)
Preceded by long and short RR-intervals
Triggered by an early premature ventricular contraction