Bikash Kumar Sah 2 Semester Pucmas
Bikash Kumar Sah 2 Semester Pucmas
Bikash Kumar Sah 2 Semester Pucmas
Non-drug Approach
Drug Approach
I’M CONSTIPATED, NOW WHAT?
Non-Drug Measures:
There are many different types of drugs that can be used for
constipation:
Bulk-forming Agents
Emollients/Stool Softeners
Osmotics
Hyper-osmotics
Stimulants
I’M CONSTIPATED, NOW WHAT?
Bulk-Forming Agents:
Examples: Metamucil, Benefiber, FiberSure
Are considered the safest agents and are suitable for long-term use
Each dose of a bulk-forming laxative should be administered with
a full glass of water or juice
Do not use if patient is dehydrated or fluid restricted
Are the drug of choice for prevention; not for immediate relief
I’M CONSTIPATED, NOW WHAT?
Emollients/Stool Softeners
Example: Docusate
Used for prevention; not for immediate relief
Used very often but lack of data showing it actually works
Company says that this product “makes it easier to go”
I’M CONSTIPATED, NOW WHAT?
Osmotics:
Examples: Milk of Magnesia
Limitations for use of this group of laxatives include frequent
diarrhea, and multiple electrolyte abnormalities.
Should be administered with sufficient water to prevent
dehydration.
Not used very often
I’M CONSTIPATED, NOW WHAT?
Hyper-Osmotics:
Examples: Glycerin Suppositories, Lactulose Syrup, Lax-a-Day
(PEG 3350)
PEG produces the loosest stool and overall greatest efficacy
compared to other members in this class. It may have benefit in
patients unresponsive to other treatments. Daily use of PEG is safe
and does not have significant side effects and may facilitate the
discontinuation of other laxatives. May take 2-4 days to see an
effect. This is the drug of choice in almost all situations!
Lactulose is very safe to use long term. May see increase in gas
and bloating compared to other options. Takes 1-2 days to work.
Glycerin suppositories have a quicker onset of action (usually 30-
60 minutes). They are less effective if the stool is dry and hard.
I’M CONSTIPATED, NOW WHAT?
Stimulants:
Examples: Senokot, Dulcolax (bisacodyl)
This group produces rhythmic muscle contractions in the intestines
and may be recommended if osmotic laxatives fail or are not
tolerated.
Are usually given at bedtime and they usually provide overnight
relief (work within 8-12 hours).
SPECIAL CONSIDERATIONS IN THE ELDERLY