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    Kortikosteroid

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    Intan Permatasari
    The document discusses the adrenal glands and corticosteroids. It describes how Addison and Cushing examined patients with adrenal damage and hypercorticoidism. The adrenal cortex secretes glucocorticoids like cortisol and mineralocorticoids like aldosterone. Corticosteroids have anti-inflammatory, immunosuppressive, and anti-allergic effects. They are used to treat various respiratory, skin, joint, and other conditions. Both oral and topical corticosteroids can cause side effects with long term use.

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    Kortikosteroid

    Uploaded by

    Intan Permatasari
    95 views14 pages
    The document discusses the adrenal glands and corticosteroids. It describes how Addison and Cushing examined patients with adrenal damage and hypercorticoidism. The adrenal cortex secretes glucocorticoids like cortisol and mineralocorticoids like aldosterone. Corticosteroids have anti-inflammatory, immunosuppressive, and anti-allergic effects. They are used to treat various respiratory, skin, joint, and other conditions. Both oral and topical corticosteroids can cause side effects with long term use.

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    The document discusses the adrenal glands and corticosteroids. It describes how Addison and Cushing examined patients with adrenal damage and hypercorticoidism. The adrenal cortex secretes glucocorticoids like cortisol and mineralocorticoids like aldosterone. Corticosteroids have anti-inflammatory, immunosuppressive, and anti-allergic effects. They are used to treat various respiratory, skin, joint, and other conditions. Both oral and topical corticosteroids can cause side effects with long term use.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    95 views14 pages

    Kortikosteroid

    Uploaded by

    Intan Permatasari
    The document discusses the adrenal glands and corticosteroids. It describes how Addison and Cushing examined patients with adrenal damage and hypercorticoidism. The adrenal cortex secretes glucocorticoids like cortisol and mineralocorticoids like aldosterone. Corticosteroids have anti-inflammatory, immunosuppressive, and anti-allergic effects. They are used to treat various respiratory, skin, joint, and other conditions. Both oral and topical corticosteroids can cause side effects with long term use.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 14

    Introduction

    • Addison, examines patients with adrenal gland damage (1855)


    • Cushing, symptoms of hypercorticosis due to corticosteroid
    hypersecretion (1932)
    Cortex
    Secretion:
    1. Glucocorticoid: Cortisol & Corticosteron
    (Zona Fasiculata)
    2. Mineralokortikoid: Aldosteron
    (Zona Glomerulosa)
    Mechanism Pathway
    • Anti-Inflamation: Block Phospholipase-A2 Enzym
    • Imunosupresif
    • Ant-Alergic: block Ig-E Mastcells Degranulation ↑ Sensitivity
    𝜷2-Receptor
    Indication
    • Subtitution Therapy
    • Respiratory Distress Syndrom
    • Arthritis
    • Rheumatic Heart Disease
    • Renal Failure
    • Dermatomiositis
    • Asthma
    • Alergic
    • Conjungtivitis
    • Eczematous eruption
    • Chronic Hepatitis
    • Alcoholic Hepatitis
    • Malignancy
    • Hematologic
    • Shock
    • Medulla spinalis trauma
    • Edema Cerebral
    Corticosteroid Systemic
    Prednisolon, Methylprednisolon, Dexametason

    - Per Oral
    - Using high doses for the first time, then within 2 weeks reduced
    - Caution long-term use!!
    - Side Effect:
    1. Cushing Sindrom: Ostheoporosis, Moonface, Hipertrichosis,
    Impotency)
    2. Renal Damage
    Corticosteroid Topical
    • Inhalation
    Beclometason (Quar), Triamsinolon, Flunisolida (Aerobid), &
    Budesomida (Pulmicort), Flutikason (Aerospan), Mometason (Asmanex)
    & Siklesonida (Alvesco)
    - First line 𝜷2-Mimetics
    - Benefit: directly to the organs
    - Side Effect:
    1. Local : Hoarse voice, candidiasis, Cough
    2. Systemic : Thinning of the skin, cataract, glaukoma, pneumonia,
    metabplic disorder (glucosa, insulin, trigliserid), psychologic
    disorder (Euphoria & depression)
    • Dermal
    - Benefit: Anti-Inflamation & Anti-mitosis
    - Can effectively cure various forms of eczema and dermatitis,
    psoriasis and prurigo, bee sting
    - Side Effect:
    Atrofia, striae, inflamation, telengaectasia, acne, rosacea, glaukoma,
    keratitis herpetica
    - Contraindication: should not be used in bacterial infection, viruses,
    fungi, parasites, acne and ulcers
    Drug of choice
    • Level 1: Hidrokortison 1%, eczema; prurigo, pruritus; dermatitis, bee
    sting, alergic reaction
    • Level 2: Triamsinolon 0.1 % eczema alergica/contact, eczema atopic
    • Level 3: reduces mitosis ex: psoriasis, lichen, lupus discoid
    • Level 4: High risk
    Tingkat I. Lemah

    Hidrokortison Asetat 1%

    Metilprednisolon Asetat 2.5 Neo Medrol

    Tingkat II. Sedang

    Desoksimetason + salis 0.25% Esperson

    Deksametason + klorheksidin 0.04 *Dexatopic

    Hidrokortison butirat 0.1 Locoid

    Flukortolon pivalat 0.25 Ultralan

    flumetason pivalat 0.02 Locacorten

    fluosinolon asetonida 0.025 *Synalar

    flupredniden +neomisin 0.5% 0.1 *Decoderm3

    klobetason butirat 0.05 Emovate

    triamsinolon asetonida 0.1 Kenacort-A


    Tingkat III. Kuat

    Beklometason dipropionat 0.025% Cleniderm

    alklometason dipropionat 0.05 Perderm, Aclosone

    betametason valerat 0.1 Celestoderm-V

    betametason dipropionat 0.05 Diprosone-OV

    budesonida - 0.025 Preferid

    diflukortolon valerat 0.1 Nerisona

    fluklorolon asetonida 0.025 Topilar-N

    flutikason propionat 0.05 Cutivate

    halometason - 0.05 Sicorten

    halsinonida - 0.1 Halog

    mometason furoat 0.1 Elocon

    prednikarbat - 0.25 Dermatop


    Tingkat IV. Sangat Kuat
    Klobetasol Propionat 0.05% Desmovate
    Penggunaan pada penyakit

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