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    Pharmacology of Testosterone: Made By: Miangul Ali Gohar

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    Ali Gohar
    Testosterone is a steroid hormone that determines male sexual characteristics. It is synthesized in the testes, ovaries, and adrenal glands through a multi-step pathway involving the hypothalamus and pituitary gland. Testosterone has various effects throughout the body, including increasing muscle and bone mass, stimulating hair growth and libido, and supporting the development of male sex organs. While therapeutic uses exist, high levels can also cause side effects like hair loss and breast growth. Treatments aim to inhibit testosterone's effects by blocking its synthesis or receptor activity.

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    Pharmacology of Testosterone: Made By: Miangul Ali Gohar

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    Ali Gohar
    92 views21 pages
    Testosterone is a steroid hormone that determines male sexual characteristics. It is synthesized in the testes, ovaries, and adrenal glands through a multi-step pathway involving the hypothalamus and pituitary gland. Testosterone has various effects throughout the body, including increasing muscle and bone mass, stimulating hair growth and libido, and supporting the development of male sex organs. While therapeutic uses exist, high levels can also cause side effects like hair loss and breast growth. Treatments aim to inhibit testosterone's effects by blocking its synthesis or receptor activity.

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    Testosterone is a steroid hormone that determines male sexual characteristics. It is synthesized in the testes, ovaries, and adrenal glands through a multi-step pathway involving the hypothalamus and pituitary gland. Testosterone has various effects throughout the body, including increasing muscle and bone mass, stimulating hair growth and libido, and supporting the development of male sex organs. While therapeutic uses exist, high levels can also cause side effects like hair loss and breast growth. Treatments aim to inhibit testosterone's effects by blocking its synthesis or receptor activity.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    92 views21 pages

    Pharmacology of Testosterone: Made By: Miangul Ali Gohar

    Uploaded by

    Ali Gohar
    Testosterone is a steroid hormone that determines male sexual characteristics. It is synthesized in the testes, ovaries, and adrenal glands through a multi-step pathway involving the hypothalamus and pituitary gland. Testosterone has various effects throughout the body, including increasing muscle and bone mass, stimulating hair growth and libido, and supporting the development of male sex organs. While therapeutic uses exist, high levels can also cause side effects like hair loss and breast growth. Treatments aim to inhibit testosterone's effects by blocking its synthesis or receptor activity.

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    Download as pptx, pdf, or txt
    of 21

    Pharmacology of

    Testosterone
    Made By: Miangul Ali Gohar
    Testosterone: A steroid hormone which
    determines the primary and secondry male
    sexual characteristics.
     Site of synthesis: Testes,ovaries, and adrenal glands
    Avalible forms: two forms endogenous
    and exogenous
     Endogenous forms: Testosterone,DHT
     Exogenous forms:oxandronol stanozol
    Pathway of synthesis: Multistep
    pathway
     1. Release of GnRh from Hypothalmus
     2.Release of Lh from ant. Pituatary gland by action of GnRh
     3.Action of Lh on leydig cells of seminiferous tubule
    Action of Lh on Leydigs cell:
     Lh binds to receptor on leydig cell
     Causes cascade of intracellular signalling
     Ultimately leydig cells releases Testosterone.
    Testosterone blood transport:

     Mainly in three forms


     1.By binding to SHBG
     2.By binding to plasma albumin
     3.As free form
    MOA:

     As testosterone is a steroid hormone it passes freely through cell membrane


     Binds to cytosolic receptor to form homone receptor complex
     Hormone receptor complex enters the nucleus binds to specific site on dna
    which ultimately causes protein synthesis
    Action of testosterone in body:
     Acts in two forms:
     1.without undergoing any biochemical change in organs like liver,adipose
    tissues and and muscles.
     As DHT in tissues like skin and prostate gland by the action of 5-alpha
    reductase on testosterone
    Effect on liver:
     Increases liver protein synthesis
    Effect on Bone:

     Increases Bone density


     Deficiency can cause osteoporosis
    Effect on muscle mass:

     Has anabolic effect on muscle mass i.e increase muscle mass by increasing
    muscle proteins.
     Indivisuals with low testosterone levels will suffer from muscle weakness.
    Effect on mode and libido:

     Normal levels stabalizes mode,increases libido,and may have positive


    cognitive ability
     Indivisual with low serum level will have opposite effect
    Effect on sex organs:

     Normal levels causes penile growth,high sperm count and prostate growth
     Low serum concentration can cause erectile dysfunction, low sperm count
    Effect on skin and heamatopoises:

     Causes hair growth in chest and genitalia.


     Causes skin thickening
     Increases heamatopoises will low levels can cause anemia
    Therapeutic uses:

     Used to treat hypogonadism


     Useful therphy in osteoporosis.
     Used to treat wasting syndrome
     Used to treat severe burns
     Pituitary dwarfism
    Toxicities:

     In male high serum conc. Can caue androgenic alopecia and


    gynaecomastia.
     In females high level of testosterone causes hairsutism and dysmenorrhea
    Anti testosterone:

     GnRH inhibitors: e.g leuprolide used mainly in prostatic carcinomas


     Receptor inhibitors: flumatide use in treating prostatic carcinomas
     5-alpha reducatase inhibitors: e.g finasteride usefull in treating BPH and hair
    loss

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