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    Picornaviridae & Adenoviridae - Raja Pardomuan Harahap

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    M. Ramazali
    The document discusses several topics regarding picornaviruses and adenoviruses: 1. Picornaviruses include enteroviruses like poliovirus, coxsackieviruses, echoviruses, rhinoviruses, and hepatoviruses. Coxsackieviruses can cause myocarditis, hand-foot-and-mouth disease, and herpangina. 2. Rhinoviruses are the most common cause of the common cold. They grow best at 33°C and are sensitive to low pH. 3. Adenoviruses can cause pharyngitis, pneumonia, conjunctivitis. They have linear

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    Picornaviridae & Adenoviridae - Raja Pardomuan Harahap

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    M. Ramazali
    55 views63 pages
    The document discusses several topics regarding picornaviruses and adenoviruses: 1. Picornaviruses include enteroviruses like poliovirus, coxsackieviruses, echoviruses, rhinoviruses, and hepatoviruses. Coxsackieviruses can cause myocarditis, hand-foot-and-mouth disease, and herpangina. 2. Rhinoviruses are the most common cause of the common cold. They grow best at 33°C and are sensitive to low pH. 3. Adenoviruses can cause pharyngitis, pneumonia, conjunctivitis. They have linear

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    The document discusses several topics regarding picornaviruses and adenoviruses: 1. Picornaviruses include enteroviruses like poliovirus, coxsackieviruses, echoviruses, rhinoviruses, and hepatoviruses. Coxsackieviruses can cause myocarditis, hand-foot-and-mouth disease, and herpangina. 2. Rhinoviruses are the most common cause of the common cold. They grow best at 33°C and are sensitive to low pH. 3. Adenoviruses can cause pharyngitis, pneumonia, conjunctivitis. They have linear

    Copyright:

    © All Rights Reserved
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    Download as pptx, pdf, or txt
    55 views63 pages

    Picornaviridae & Adenoviridae - Raja Pardomuan Harahap

    Uploaded by

    M. Ramazali
    The document discusses several topics regarding picornaviruses and adenoviruses: 1. Picornaviruses include enteroviruses like poliovirus, coxsackieviruses, echoviruses, rhinoviruses, and hepatoviruses. Coxsackieviruses can cause myocarditis, hand-foot-and-mouth disease, and herpangina. 2. Rhinoviruses are the most common cause of the common cold. They grow best at 33°C and are sensitive to low pH. 3. Adenoviruses can cause pharyngitis, pneumonia, conjunctivitis. They have linear

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    © All Rights Reserved
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    of 63

    PICORNAVIRIDAE &

    ADENOVIRIDAE
    RAJA PARDOMUAN HARAHAP :-)
    PRE-TEST DULU WOY :-)
    1
    Regarding rhinoviruses, which one of the following is most accurate?

    (A) Rhinoviruses are an important cause of viral meningitis and myocarditis.

    (B) The rhinovirus vaccine is recommended for all children over 2 years of age.

    (C) Rhinoviruses have many serological types, so a person can have many
    infections caused by these viruses.

    (D) Rhinoviruses are not inactivated by stomach acid, so they infect the upper
    gastrointestinal tract and are one of the causes of viral diarrhea.

    (E) An important feature of the laboratory diagnosis of rhinoviruses is finding


    cytopathic effect in cell culture consisting of multinucleated giant cells.
    2
    The minor illness such as fever, headache,
    malaise, sore throat, and vomiting refers to
    what outcome in poliovirus infections?

    A. Asymptomatic illness
    B. Abortive poliomyelitis
    C. Non paralytic poliomyelitis
    D. Aseptic meningitis
    E. Paralytic polio
    3 In this outcome, the virus spreads from the
    blood to the anterior horn cells of the spinal
    cord and motor cortex of the brain. This
    condition refers to what outcome in
    poliovirus infections?

    A. Asymptomatic illness
    B. Abortive poliomyelitis
    C. Non paralytic poliomyelitis
    D. Aseptic meningitis
    E. Paralytic polio
    4
    Enterovirus 68 causes what disease?

    A. Polio-like paralytic disease


    B. Hand-foot-and-mouth disease
    C. Aseptic meningitis
    D. Common cold
    E. Acute hemorrhagic conjunctivitis
    5

    NAME THE DISEASE THAT IS


    INDICATED BY ATTACKING OF
    THE BETA CELLS OF ISLETS
    LANGERHANS BY
    COXSACKIEVIRUS B.
    6

    NAME THE DISEASE THAT IS


    CAUSED BY ENTEROVIRUS 71.
    7

    NAME THE DISEASE THAT IS


    CAUSED BY ADENOVIRUS 5.
    8

    Etiologic agent that cause devil's


    grip?
    9

    Mention virus and numeric type


    that causes acute respiratory
    infection in millitary recruits.
    10

    What type of vaccine that can cause


    paralytic polio?
    PICORNAVIRIDAE
    PICORNA VIRIDAE
    P = POSITIVE (similar with mRNA)

    PICO = SO SMALL

    ICO = ICOSAHEDRAL

    RNA = GENOME IS RNA

    NA = NAKED CAPSID (naked eumh)


    PICORNA VIRIDAE - PERCCH
    ENTEROVIRUS : POLIOVIRUS, ECHOVIRUS, COXSACKIEVIRUS

    RHINOVIRUS

    HEPATOVIRUS - HEPATITIS A VIRUS

    CARDIOVIRUS

    APHTHOVIRUS
    ENTEROVIRUS are distinguished
    from RHINOVIRUS,
    ENTEROVIRUS is stable at pH 3.
    The capsids of ENTEROVIRUSES
    are resistant to harsh
    environmental conditions and
    conditions in GI tract, which
    facilitates their transmission by
    fecal-oral route. They initiate GI
    tract infections, but rarely cause
    enteric disease.
    COXSACKIEVIRUSES are divided
    into 2 groups, COXSACKIEVIRUS
    A & B, then subdivided into
    numeric serotypes.
    ECHOVIRUS
    Enteric Cytopathic Human Orphan
    RHINOVIRUS
    Major cause of the common cold.
    Sensitive to acidic pH & replicate
    poorly at temperature above 330C.
    At least 80% of the rhinoviruses and
    several serotypes of coxsackievirus
    bind to the intercellular adhesion
    molecule-1 (ICAM-1) expressed on
    epithelial cells, fibroblasts, and
    endothelial cells.
    Several coxsackieviruses, echoviruses, and
    other enteroviruses bind to decay
    accelerating factor (CD55), and
    coxsackievirus B shares a receptor with
    adenovirus. Poliovirus binds to a different
    molecule (PVR/CD155) that is similar to
    the receptor for HSV. The poliovirus
    receptor is present on many different
    human cells, but not all of these cells will
    replicate the virus.
    ENTEROVIRUS
    Change in the receptor-binding
    VP1 protein gene has occurred by
    recombination with another
    enterovirus. This development has
    prompted a preference for use of
    the inactivated polio vaccine.
    Polioviruses are spread most
    often during the summer and
    autumn.

    Pleconaril is available on a limited


    basis. The drug inhibits
    penetration of picornaviruses into
    the cell. It must be administered
    early in the course of the
    infection.
    POLIOVIRUS
    1. ASYMPTOMATIC ILLNESS (90%)

    2. ABORTIVE POLIOMYELITIS (minor illness) -


    fever, headache, malaise, sore throat, vomiting

    3. NONPARALYTIC, POLIOMYELITIS or ASEPTIC


    MENINGITIS - progress into CNS and the
    meninges (back pain, muscle spasm)

    4. PARALYTIC POLIO (major illness) - virus


    spreads from the blood to the anterior horn
    cells of the spinal cord and motor cortex.
    1. PARALYTIC POLIOMYELITIS - asymmetric flaccid
    paralysis, no sensory loss, may involve only a few
    muscle groups (e.g., one leg) or there may be
    complete flaccid paralysis of all four extremities.

    2. BULBAR POLIOMYELITIS - more severe, may involve


    the muscles of the pharynx, vocal cords, and
    respiration, and may result in death in 75% of
    patients.

    3. POSTPOLIO SYNDROME - Poliovirus is not present,


    but the syndrome is believed to result from a loss of
    neurons in the initially affected nerves.
    COXSACKIEVIRUS &
    ECHOVIRUS
    COXSACKIEVIRUS A - vesicular lesion = herpangina

    COXSACKIEVIRUS B - myocarditis, pleurodynia (Bornholm


    disease, devil's grip), myocardial and
    pericardial infections

    ENTEROVIRUS 68 - polio-like paralytic disease

    COXSACKIEVIRUS A16, ENTEROVIRUS 71 - hand-foot-and-mouth disease

    ECHOVIRUS 11 - aseptic meningitis in summer and


    autumn, rhinovirus-like symptoms
    resembling common cold

    COXSACKIEVIRUS A21,24; - rhinovirus-like symptoms resembling


    ECHOVIRUS 20 common cold

    ENTEROVIRUS 70,COXSACKIEVIRUSA24 - acute hemorrhagic conjunctivitis


    RHINOVIRUS
    RHINOVIRUSES are the most important cause of
    the common cold and upper respiratory tract
    infections. Such infections are self-limited,
    however, and do not cause serious disease. More
    than 100 serotypes of rhinovirus have been
    identified. At least 80% of the rhinoviruses have a
    common receptor that is also used by some of the
    coxsackieviruses. This receptor has been identified
    as ICAM-1, a member of the immunoglobulin
    superfamily, which is expressed on epithelial,
    fibroblast, and B-lymphoblastoid cells.
    Unlike the ENTEROVIRUSES,
    RHINOVIRUSES are unable to replicate in
    the gastrointestinal tract. The
    RHINOVIRUSES are labile to acidic pH.
    Also, they grow best at 33° C, a feature
    that contributes to their preference for
    the cooler environment of the nasal
    mucosa.
    ADENOVIRIDAE
    ADENOVIRIDAE
    • Double-stranded DNA viruses.
    • Linear genome
    • Double-stranded DNA
    • NO for NON ENVELOPE OR NAKED
    • “Adeno” from “adenoid” for gland
    or mucosa.
    The E1A protein is also an
    oncogene, and together with the
    E1B protein, it can stimulate cell
    growth by binding to the cellular
    growth-suppressor proteins
    p105RB (p105RB retinoblastoma
    gene product) (E1A) and p53
    (E1B).
    The viral E3 and E1A
    proteins block
    apoptosis induced by
    cellular responses to
    the virus or by T-cell
    or cytokine (e.g.,
    tumor necrosis factor
    [TNF]-α) actions.
    POST-TEST EUMH :-(
    1

    The drug inhibits penetration of


    picornaviruses into the cell. It must be
    administered early in the course of
    the infection. What drug is that?
    2
    Regarding adenoviruses, which one of the following statements is
    most accurate?

    (A) Acyclovir is the drug of choice for life-threatening infections.

    (B) They cause pharyngitis, pneumonia, and conjunctivitis (“pink eye”).

    (C) They are often transmitted across the placenta and cause hydrocephalus
    in the fetus.

    (D) The adenovirus vaccine is recommended for all children prior to entering
    first grade.

    (E) Laboratory diagnosis depends on seeing multinucleated giant cells on


    biopsy as the virus has not been grown in cell culture.
    3

    ECHO IN ECHOVIRUS, IS
    ABBREVIATION FROM WHAT?
    4

    WHAT IS THE OTHER DISEASE'S


    NAME OF “PLEURODYNIA” CAUSED
    BY COXSACKIEVIRUS B?
    5

    NAME THE DISEASE THAT IS INDICATED WITH


    “PINKEYE” CAUSED BY ADENOVIRUS 3 AND 7?
    6

    NAME THE DISEASE ESPECIALLY IN


    INFANTS CAUSED BY ADENOVIRUS
    40, 41, 42?
    7

    WHAT IS THE BEST TEMPERATURE


    FOR BEST GROWTH OF
    RHINOVIRUSES?
    8

    13-year-old boy has fever and


    severe chest pain with
    headache, fatigue, and aching muscles
    lasting for 4 days. What is the
    diagnosis and the etiologic agent ?
    9

    What is the common cause of acute


    hemorrhagic conjunctivitis?
    10

    Which proteins that


    block apoptosis from
    etiologic agent that
    cause those
    appearance ?

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