Heart Transplantation: Arshad Jawed 303-B

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A heart transplant involves replacing a patient's failing heart with a healthy donor heart to treat end-stage heart failure or severe coronary artery disease. The donor heart can either replace the recipient's heart or be placed beside it to support it.

Patients with advanced kidney, lung, or liver disease, active cancer, life-threatening unrelated diseases, severe vascular issues, high pulmonary resistance, recent thromboembolism, severe obesity may be less suitable candidates for heart transplantation.

Potential post-operative complications include infection, sepsis, organ rejection, and side effects of immunosuppressive medications like increased risk of infections or cancers since the transplant recipient's immune system tries to reject the donor heart.

Heart Transplantation

ARSHAD JAWED
303-B
Heart Transplantation

A heart transplant, or a cardiac transplant, is a surgical transplant


procedure performed on patients with end-stage heart failure or
severe coronary artery disease when other medical or surgical
treatments have failed.
The patient's own heart is either removed and replaced with the
donor heart (orthotopic procedure) or, much less commonly, the
recipient's diseased heart is left in place to support the donor heart
 Not having a human donor heart available, James D. Hardy of the
University of Mississippi Medical Center transplanted the heart
of a chimpanzee into the chest of a dying Boyd Rush in the early
morning of Jan. 24, 1964.

 The world's first human-to-human heart transplant was


performed by South African cardiac surgeon Christiaan Barnard.
Patient Louis Washkansky received this transplant on December 3,
1967, at the Groote Schuur Hospital in Cape Town, South Africa.
Washkansky, however, died 18 days later from pneumonia.
CONTRADICTION

 Some patients are less suitable for a heart transplant, especially if they suffer from other
circulatory conditions related to their heart condition. For Example;
 Advanced kidney, lung, or liver disease.
 Active cancer if it is likely to impact the survival of the patient
 Life-threatening diseases unrelated to heart failure, including acute infection or systemic
disease such as systemic lupus erythematosus, sarcoidosis or amyloidosis
 Vascular disease of the neck and leg arteries.
 High pulmonary vascular resistance – over 5 or 6 Wood units.
 Insulin-dependent diabetes with severe organ dysfunction
 Recent thromboembolism such as stroke
 Severe obesity
COMPLICATIONS

Post-operative complications include infection, sepsis, organ


rejection as well as the side-effects of the immunosuppressive
medication. Since the transplanted heart originates from another
organism, the recipient's immune system typically attempts to
reject it. The risk of rejection never fully goes away, and the
patient will be on immunosuppressive drugs for the rest of their
life, but these may cause unwanted side effects, such as
increased likelihood of infections or development of certain
cancers.
SURVIVAL RATE

Survival — Approximately 85 to
90 percent of heart transplant
patients are living one year
after their surgery, with an
annual death rate of
approximately 4 percent
thereafter. The three-year
survival approaches 75 percent.

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