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    Opioid

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    Nadia Dwi Arini
    This document discusses analgesic opioids and provides information on their history, classification, and mechanism of action. It explains that opioids act as agonists at opioid receptors in the central nervous system and periphery, mimicking endogenous ligands. This results in activation of pain-modulating systems and a decrease in neurotransmission by presynaptic inhibition of neurotransmitter release. It also notes the roles of different opioid receptor subtypes in producing analgesia versus side effects like hypoventilation.

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    Opioid

    Uploaded by

    Nadia Dwi Arini
    15 views8 pages
    This document discusses analgesic opioids and provides information on their history, classification, and mechanism of action. It explains that opioids act as agonists at opioid receptors in the central nervous system and periphery, mimicking endogenous ligands. This results in activation of pain-modulating systems and a decrease in neurotransmission by presynaptic inhibition of neurotransmitter release. It also notes the roles of different opioid receptor subtypes in producing analgesia versus side effects like hypoventilation.

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    anestesi opioid

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    This document discusses analgesic opioids and provides information on their history, classification, and mechanism of action. It explains that opioids act as agonists at opioid receptors in the central nervous system and periphery, mimicking endogenous ligands. This results in activation of pain-modulating systems and a decrease in neurotransmission by presynaptic inhibition of neurotransmitter release. It also notes the roles of different opioid receptor subtypes in producing analgesia versus side effects like hypoventilation.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    15 views8 pages

    Opioid

    Uploaded by

    Nadia Dwi Arini
    This document discusses analgesic opioids and provides information on their history, classification, and mechanism of action. It explains that opioids act as agonists at opioid receptors in the central nervous system and periphery, mimicking endogenous ligands. This results in activation of pain-modulating systems and a decrease in neurotransmission by presynaptic inhibition of neurotransmitter release. It also notes the roles of different opioid receptor subtypes in producing analgesia versus side effects like hypoventilation.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 8

    ANALGETIK OPIOID

    SEJARAH
    KLASIFIKASI
    Mechanism of Action
    • Opioids act as agonists at specific opioid receptors at presynaptic and
    postsynaptic sites in the central nervous system (CNS) (mainly the
    brainstem and spinal cord) as well as in the periphery.
    • Opioid receptors normally are activated by three endogenous peptide
    opioid receptor ligands known as enkephalins, endorphins, and
    dynorphins.
    • Opioids mimic the actions of these en- dogenous ligands by binding
    to opioid receptors, result- ing in activation of pain-modulating
    (antinociceptive) systems.
    • The principal effect of opioid receptor activation is a decrease in
    neurotransmission, by presynaptic inhibition of neurotransmitter
    release (acetylcholine, dopamine, norepinephrine, substance P)
    • Th m receptors are principally responsible for su- praspinal and spinal
    analgesia.
    • Theoretically, activation of a subpopulation of m receptors (mu1) is
    speculated to produce analgesia, whereas mu2 receptors are
    responsi- ble for hypoventilation, bradycardia, and physical depen-
    dence.
    • Activation of k receptors results in inhibition of neu- rotransmitter
    release via N-type calcium channels.

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