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    Nucleic Acid Chemistry

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    kay
    This document provides an outline on the topic of nucleotides and nucleic acids. It covers basics, structures of nucleotides and nucleic acids, chemistry, and other functions of nucleotides. The outline contains over 40 subtopics that will be discussed, including DNA and RNA structures, base pairing, replication, sequencing, and more.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd

    Nucleic Acid Chemistry

    Uploaded by

    kay
    238 views66 pages
    This document provides an outline on the topic of nucleotides and nucleic acids. It covers basics, structures of nucleotides and nucleic acids, chemistry, and other functions of nucleotides. The outline contains over 40 subtopics that will be discussed, including DNA and RNA structures, base pairing, replication, sequencing, and more.

    Original Description:

    Nucleic Acid Chemistry

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    © © All Rights Reserved

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    This document provides an outline on the topic of nucleotides and nucleic acids. It covers basics, structures of nucleotides and nucleic acids, chemistry, and other functions of nucleotides. The outline contains over 40 subtopics that will be discussed, including DNA and RNA structures, base pairing, replication, sequencing, and more.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    238 views66 pages

    Nucleic Acid Chemistry

    Uploaded by

    kay
    This document provides an outline on the topic of nucleotides and nucleic acids. It covers basics, structures of nucleotides and nucleic acids, chemistry, and other functions of nucleotides. The outline contains over 40 subtopics that will be discussed, including DNA and RNA structures, base pairing, replication, sequencing, and more.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 66
    At a glance
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    The key takeaways are that the document outlines the basics of nucleotides and nucleic acids including their structure, chemistry, and other functions.

    Nucleotides are composed of a nitrogenous base, a pentose sugar, and a phosphate group. Nucleic acids like DNA and RNA are polymers composed of nucleotides linked together by phosphodiester bonds between the sugar and phosphate groups.

    The major components of nucleotides are purine bases like adenine and guanine, pyrimidine bases like cytosine and thymine, the pentose sugar ribose, and a phosphate group.

    1

    Molecular Biochemistry

    Nucleotides and
    Nucleic Acids
    2
    Outline

    1. Some Basics
    2. Nucleic Acid Structure
    3. Nucleic Acid Chemistry
    4. Other Functions of Nucleotides
    Structure of nucleotides
    Structure of nucleotides
    Major purine bases of nucleic acids
    Major pyrimidine bases of nucleic acids
    Conformations of ribose
    Conformations of ribose
    Deoxyribonucleotides of nucleic acids
    Ribonucleotides of nucleic acids
    Nucleotide and nucleic acid nomenclature
    Some minor purine and pyrimidine bases
    Some minor purine and pyrimidine bases
    Some adenosine monophosphates
    Phosphodiester linkages in the covalent
    backbone of DNA and RNA
    Hydrolysis of RNA under alkaline conditions
    Tautomeric forms of uracil
    Schematic representation of nucleotide
    sequence
    Absorption spectra of common nucleotides
    Hydrogen-bonding patterns in the base pairs
    defined by Watson and Crick
    The Avery-Macleod-McCarty experiment
    The Hershey-Chase experiment
    X-ray diffraction pattern of DNA
    Watson-Crick model for the structure of DNA
    Complementarity of strands in the DNA
    double helix
    Replication of DNA as suggested by
    Watson and Crick
    Structural variation in DNA
    Comparison of A, B, and Z forms of DNA
    Comparison of A, B, and Z forms of DNA
    Palindromes and mirror repeats
    Hairpins and cruciforms
    DNA structures containing three of four
    DNA strands- Hoogsteen pairing

    Hoogsteen pairing
    DNA structures containing three of four
    DNA strands- Guanosine tetraplex
    DNA structures containing three of four
    DNA strands- H-DNA
    Prokaryotic mRNA
    Typical right-handed stacking pattern of
    single-stranded RNA
    Secondary structure of RNAs
    Base-paired helical structures in an RNA
    Three-dimensional structure in RNA
    Reversible denaturation and annealing
    (renaturation) of DNA
    Heat denaturation of DNA
    Partially denatured DNA
    DNA hybridization
    Some well-characterized nonenzymatic
    reactions of nucleotides
    Some well-characterized nonenzymatic
    reactions of nucleotides
    Formation of pyrimidine dimers induced by
    UV light
    Chemical agents that cause DNA damage
    Chemical agents that cause DNA damage
    Alkylating agents- dimethylsulfate
    DNA sequencing by the Sanger method
    DNA sequencing by the Sanger method
    Strategy for automating DNA sequencing
    reactions
    Chemical synthesis of DNA
    Nucleoside phosphates
    The phosphate ester and phosphoanhydride
    bonds of ATP
    Some coenzymes containing adenosine
    Some coenzymes containing adenosine
    Some coenzymes containing adenosine
    Three regulatory nucleotides

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