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    4 Mumps

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    Ayu Pratiwi
    Mumps is an infectious disease caused by the mumps virus, which commonly affects the salivary glands. The most prominent symptom is swelling of the parotid glands. Complications can include meningitis, orchitis, and pancreatitis. The mumps virus is an RNA virus that spreads via droplets from infected individuals. While most cases resolve on their own, supportive care and isolation of infected individuals can help. Vaccination provides effective protection against mumps.

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    4 Mumps

    Uploaded by

    Ayu Pratiwi
    145 views18 pages
    Mumps is an infectious disease caused by the mumps virus, which commonly affects the salivary glands. The most prominent symptom is swelling of the parotid glands. Complications can include meningitis, orchitis, and pancreatitis. The mumps virus is an RNA virus that spreads via droplets from infected individuals. While most cases resolve on their own, supportive care and isolation of infected individuals can help. Vaccination provides effective protection against mumps.

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    Mumps is an infectious disease caused by the mumps virus, which commonly affects the salivary glands. The most prominent symptom is swelling of the parotid glands. Complications can include meningitis, orchitis, and pancreatitis. The mumps virus is an RNA virus that spreads via droplets from infected individuals. While most cases resolve on their own, supportive care and isolation of infected individuals can help. Vaccination provides effective protection against mumps.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    145 views18 pages

    4 Mumps

    Uploaded by

    Ayu Pratiwi
    Mumps is an infectious disease caused by the mumps virus, which commonly affects the salivary glands. The most prominent symptom is swelling of the parotid glands. Complications can include meningitis, orchitis, and pancreatitis. The mumps virus is an RNA virus that spreads via droplets from infected individuals. While most cases resolve on their own, supportive care and isolation of infected individuals can help. Vaccination provides effective protection against mumps.

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    © All Rights Reserved
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    Download as ppt, pdf, or txt
    of 18

    MUMPS

    XIE QIFENG

    Dept. of Infectious Disease


    Introduction

    Mumps is an acute respiratory tract


    infectious disease caused by mumps virus,
    it occurs primarily in school-aged children
    and adolescents.The most prominent
    manifestation is nonsuppurative swelling
    and tenderness of the salivary glands with
    one or both parotid glands involved in
    most cases.
    Introduction

    Meningitis, meningoencephalitis,
    epididymo-orchitis, oophoritis and
    pancreatitis are the common
    extrasalivary gland manefestations of
    mumps.
    Etiology
    Mumps virus (Paramyxovirus parotitis)
    belongs to Paramyxoviridae family. RNA
    virus.

    6 major proteins. nucleocapsid associated


    (S antigen) for diagnosis. Hemagglutinin-
    neuraminidase(V antigen) for protection.
    Etiology
    Sensitive to ether,ultraviolet and
    high temperature

    Humans are the only natural host


    Epidemiology
    Sources of infection:
    Patients in early course of the disease, hosts
    under covert infection.
    The period of peak contagion before or at
    the onset of parotitis.

    Route of transmission :
    Via droplet nuclei or direct contact,fomites
    Epidemic features:
    Endemic throughout the world.
    The peak incidence in winter and
    spring.
    School-aged children at high risk.
    Post-infection immunity is stable and
    long-lasting.
    Pathogenesis and Pathology

    The virus usually infecting glandular


    tissue such as parotid, orchis or oophoron.
    The main pathologic findings are
    nonsuppurative inflammatory reactions.
    The meningoencephalitis may involve
    the Fusion protein.
    Clinical Manifestations
    Incubation period: averages 16 to 18 days
    with a range of 2 to 4 weeks.

    Prodromal symptoms include low- grade fever,


    anorexia,malaise and headache.

    Parotid tenderness and ipsilateral earache


    within 1 or 2 days after the illness onset,then
    parotid is visibly enlarged and go to maximum
    size over next 2 to 3 days accompanied severe
    pain and normal or high temperature. One
    parotid enlarges after the other. The orifice of
    Stensens duct is edematous and erythematous.
    Parotid returns to normal size within a week.
    Patients with parotitis have difficulty with
    pronunciation and mastication. Citrus fruits
    and juices exacerbates the pain.
    Other salivary glands involved include
    submandibular adenitis and sublingual adenitis.
    Clinical meningitis occurs in 15% of patients
    with mumps. Its onset averages 4-5 days after
    parotitis but may before, after or in the
    absence of parotitis. Clinical features are
    headache, vomiting, fever and nuchal rigidity.
    CSF pleocytosis. Prognosis is benign.

    The onset of orchitis is abrupt with high


    temperature, chills , testicular pain and
    swelling. Impaired fertility is rare.
    Oophoritis develops in 5% postpubertal
    women with mumps. Impaired fertility is
    rare.

    Pancreatitis is manifested by severe epigastric


    pain and tenderness,fever,nausea,and vomiting.
    Diagnosis
    In most instances, the diagnosis of mumps is
    made on the basis of a exposure history and of
    parotid swelling and tenderness accompanied
    other symptoms.

    Laboratory confirmation is unnecessary in


    typical cases, exception the absence or
    recurrence of parotitis and extrasalivary glands
    involved. Serologic tests,viral isolation.
    Amylase and lipase.
    Differential Diagnosis

    Suppurative parotitis

    Other viral parotitis: caused by parainfluenza


    virus, coxsackievirus and influenza A virus.
    ---serologic tests or viral culture

    Parotid enlargement caused by other reasons


    Prognosis

    Benign and self-limited


    Major death causes are severe mumps
    encephalitis
    Treatment
    Supportive and symptomatic treatment

    Anti-viral therapy: ribavirin and interferon

    Dexamethason for meningoencephalitis

    Diethylstilbestrol for orchitis


    Prenvention
    Patients should be isolated.
    Attenuated mumps virus vaccine has been
    available. More than 90% vaccine recipients
    produced protective antibody.
    Aseptic meningitis associated with
    vaccine virus occurred in 0.025% recipients.
    Mumps vaccine should not be
    administered to pregnant women or persons
    with immunodeficiencies.
    Thanks!

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