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    Scopolamine

    Uploaded by

    Diego Felipe Blanco
    Presentación que versa sobre la Escopolamina, también llamada burundanga, su sintesis efectos y metabolismo.

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    © All Rights Reserved
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    Scopolamine

    Uploaded by

    Diego Felipe Blanco
    338 views14 pages
    Presentación que versa sobre la Escopolamina, también llamada burundanga, su sintesis efectos y metabolismo.

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    © © All Rights Reserved

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    PPTX, PDF, TXT or read online from Scribd

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    Presentación que versa sobre la Escopolamina, también llamada burundanga, su sintesis efectos y metabolismo.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    338 views14 pages

    Scopolamine

    Uploaded by

    Diego Felipe Blanco
    Presentación que versa sobre la Escopolamina, también llamada burundanga, su sintesis efectos y metabolismo.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
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    At a glance
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    Some key takeaways are that scopolamine is a tropane alkaloid found in plants like jimson weed and henbane that acts as a muscarinic antagonist. It was first isolated in 1880 and has various medical uses such as treating nausea, motion sickness, and as a anesthetic or analgesic when mixed with opioids.

    Scopolamine is synthesized in plants through a series of enzymatic reactions starting from ornithine and involving putrescine, tropinone, and a spontaneous reaction. Cytochrome P450 enzymes and various cofactors are involved in its biosynthesis.

    Scopolamine has medical uses in small doses for treating postoperative nausea, motion sickness, and gastrointestinal spasms by blocking the parasympathetic nervous system. Larger doses are used as an antiparkinson agent and anesthetic when mixed with opioids.

    SCOPOLAMINE

    Structure, What is it?,History,


    Biosynthesis, Metabolism and Excretion

    STRUCTURE

    L-Scopolamine

    WHAT IS IT?

    Tropane alkaloid and muscarinic antagonist.


    Secondary metabolite
    It comes from the Solanaceae family of plants,
    like Jimnson weed or henbane.

    HISTORY

    One of the earliest alkaloids isolated from plants


    by Albert Ladenburg in 1880, altough the jimson
    weed was used in ancient and folk medicine.

    In the 40s and 50s scopolamine was attempted to be


    synthesized in a laboratory but other compounds were
    obtained, such as diphenhydramine and pethidine.

    HISTORY

    In the 60s it began being used like an


    anesthesic and analgesic mix with opioids
    such as morphine and oxycodone.
    Nowadays scopolamine is used in a little
    dosage to treat postoperative nausea, motion
    sickness, gastrointestinal spams... and it
    works like a parasympathetic nervous system
    antagonist.
    In higher doses it is used as an antiparkinson
    agent and as an anesthesic.

    BIOSYNTHESIS
    1.
    2.
    3.

    Ornithine decarboxylase (Co-factor pyridoxal


    5-phosphate)
    Putrescine N-methyltransferase
    Putrescine oxidase (Co-factor Cu(I))

    Tropinone reductase 1
    5. Cytochrome P450 (Cyp80F1)
    6. 6--hydroxyhyoscyamine expoxidase (Cofactor L-acobate and Fe (II))
    S. Spontaneous reaction
    4.

    SIMILAR COMPOUNDS

    Atropine

    METABOLISM AND RECEPTORS

    Ways in which scopolamine can be


    administrated.

    METABOLISM AND RECEPTORS

    When scopolamine is absorbed in the digestive


    tract, it can go through the blood to different
    muscarinic receptors.
    A muscarinic receptor is a transmembrane
    protein bonded with a G-protein.

    MUSCARINIC RECEPTOR

    MUSCARINIC RECEPTOR

    METABOLISM, DEGRADATION
    AND EXCRETION

    The maximum effect is seen after 1-2 hours.


    Scopolamine is degraded in the liver through
    enzymatic hydrolysis.

    Its excreted by the kindey.

    TRIVIA

    Scopolamine is also called Burundanga.

    BIBLIOGRAPHY

    Putcha, L.; Cintrn, N. M.; Tsui, J.; Vanderploeg, J. M.; Kramer, W. G.


    (1989). "Pharmacokinetics and Oral Bioavailability of Scopolamine in
    Normal Subjects".

    Renner UD,Oertel R,Kirch W. Pharmacokinetics and pharmacodynamics


    in clinical use of scopolamine.

    Grzegorz Grynkiewicz, Maria Gadzikowska. Tropane alkaloids as


    medicinally useful natural products and their synthetic derivatives as new
    drugs.

    Flores Soto ME, Segura Torres JE. Estructura y funcin de los receptores
    acetilcolina de tipo muscarnico y nicotnico.

    Rong Li, Darwin W. Reed, Enwu Liu, Jacek Nowak, Lawrence E. Pelcher,1
    Jonathan E. Page and Patrick S. Covello. Functional Genomic Analysis of
    Alkaloid Biosynthesis in Hyoscyamus niger Reveals a Cytochrome P450
    Involved in Littorine Rearrangement.

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