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    Pleomorphic Adenoma of Parotid Gland

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    A. Pathak
    Pleomorphic adenoma is the most common tumor of the salivary glands, usually occurring in the parotid gland. It presents as a slow-growing, painless swelling and is a benign tumor consisting of a mixture of epithelial and mesenchymal cells. While typically benign, it has a small risk of malignant transformation. Surgical resection is the treatment, as it is radioresistant, and there is a tendency for recurrence after excision.

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    Pleomorphic Adenoma of Parotid Gland

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    A. Pathak
    1K views14 pages
    Pleomorphic adenoma is the most common tumor of the salivary glands, usually occurring in the parotid gland. It presents as a slow-growing, painless swelling and is a benign tumor consisting of a mixture of epithelial and mesenchymal cells. While typically benign, it has a small risk of malignant transformation. Surgical resection is the treatment, as it is radioresistant, and there is a tendency for recurrence after excision.

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    Pleomorphic adenoma is the most common tumor of the salivary glands, usually occurring in the parotid gland. It presents as a slow-growing, painless swelling and is a benign tumor consisting of a mixture of epithelial and mesenchymal cells. While typically benign, it has a small risk of malignant transformation. Surgical resection is the treatment, as it is radioresistant, and there is a tendency for recurrence after excision.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT or read online from Scribd
    Download as ppt
    1K views14 pages

    Pleomorphic Adenoma of Parotid Gland

    Uploaded by

    A. Pathak
    Pleomorphic adenoma is the most common tumor of the salivary glands, usually occurring in the parotid gland. It presents as a slow-growing, painless swelling and is a benign tumor consisting of a mixture of epithelial and mesenchymal cells. While typically benign, it has a small risk of malignant transformation. Surgical resection is the treatment, as it is radioresistant, and there is a tendency for recurrence after excision.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT or read online from Scribd
    Download as ppt
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    Pleomorphic Adenoma of

    parotid gland
    Benign: Pleomorphic Adenoma,
    Malignant: carcinoma ex pleomorphic
    adenoma
    Pleomorphic adenoma consists of
    mixed epithelial (left) and mesenchymal
    cell components(right)
    • This is the commonest tumor of salivary
    glands and commonly occurs in parotid.
    • They are benign tumors derived from
    mixture of epithelial (ductal epithelium) and
    myoepithelial cells and therefore show both
    epithelial and mesenchymal differentiation
    • It is somewhat commoner in females,
    presenting in fourth to sixth decades.
    • Patients present with a small, firm, freely
    movable, painless swelling which slowly
    increases in size.
    • Patient has complaints of difficulty in
    mastication, talking and breathing so is
    detected early.
    •Being radioresistant these tumors have to
    be surgically resected. They have a
    tendency to recur after excision.
    •Benign pleomorphic adenomas have 3 to
    15% chances of malignant
    transformation. The incidence of
    malignant transformation increases
    with duration of tumor.
    •The malignant tumor is called as
    carcinoma ex pleomorphic adenoma.
    They are highly aggressive and show
    high mortality rates.
    GROSS APPEARANCE
    • The tumor is well circumscribed
    psuedoencapsulated, rounded multilobulated,
    firm mass rarely exceeding 6cm in greatest
    dimension.
    • Although they are encapsulated at some
    locations the capsule is not fully developed
    (psuedoencapsulated) giving protrusions in
    surrounding gland rendering enucleation
    hazardous.
    • The cut surface is gray white with myxoid and
    blue translucent areas of chondroid.
    Histopathology
    • The diverse histologic pattern is in
    fact the characteristic feature of this
    neoplasm.
    • Inside fibrous capsule some areas
    have cuboidal cells arranged in tubes
    or ductlike structures or strands or
    sheets of cells.
    • These elements are typically
    dispersed in a mesenchyme like
    background of loose myxoid
    connective tissue stroma containing
    islands of chondroid tissue .
    • Sometimes well developed ducts
    lined by cuboidal to columnar cells
    with an underlying layer of deeply
    chromatic small myoepithelial cells
    are seen.
    • Loose myxoid tissue is predominant
    feature while foci of hyalinised
    connective tissue or cartilage like
    material and even bone may occur.
    • Islands of well differentiated squamous
    epithelium may also occur.
    • Sometimes tumor cells assume a stellate,
    polyhedral or spindle form.
    • In most cases there is no epithelial
    dysplasia or mitotic activity.
    Epithelial elements

    Myxoid tissue
    Biphasic appearance resulting from the admixture of epithelium & stroma.
    epithelium

    myxoid
    stroma

    (20X) 】 Epithelial
    component. 　
    Epithelial proliferation

    (20X) 】 Epithelial component.


    DUCT

    (40X) 】 Glandular (ductal) component.


    Epithelium

    stroma

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