John Hardy (geneticist)

Sir John Anthony Hardy FRS[1] (born 9 November

Sir
1954) is a human geneticist and molecular biologist at
the Reta Lila Weston Institute of Neurological Studies John Hardy
FRS
at University College London with research interests in
neurological diseases.[3][4][5][6] Born John Anthony Hardy
9 November 1954
Alma mater University of Leeds (BSc)
Education Imperial College London (PhD)

Hardy attended St Ambrose College in the late 1960s, Awards Breakthrough Prize in Life
where his interest in biochemistry was encouraged by Sciences (2016)
his biology teacher, Mrs Cox.[7] He received his FRS (2009)[1]
Bachelor of Science degree from the University of FMedSci (2008)[2]
Leeds in 1976[8] and his PhD from Imperial College
Scientific career
London in 1981[8] for research on dopamine and
Institutions St Mary's Hospital, London
amino acid neuropharmacology.
Mayo Clinic
National Institute on Aging
Career and research University of South Florida
University College London
Following his PhD, Hardy did postdoctoral research at
the MRC Neuropathogenesis Unit in Newcastle upon Thesis The release of amino acids and
Tyne, England and then further postdoctoral work at phenylethylamine from
the Swedish Brain Bank in Umeå, Sweden where he mammalian synaptosomes (http://
started to work on Alzheimer's disease.[8] search.proquest.com/docview/30
1416730) (1981)
He became Assistant Professor of Biochemistry at St. Website ucl.ac.uk/rlweston-inst/people
Mary's Hospital, Imperial College London in 1985 and /john (http://ucl.ac.uk/rlweston-ins
initiated genetic studies of Alzheimer's disease there.[9] t/people/john)
He became Associate Professor in 1989 and then took
the Pfeiffer Endowed Chair of Alzheimer's Research at the University of South Florida, in Tampa in
1992. In 1996 he moved to Mayo Clinic in Jacksonville, Florida, as Consultant and Professor of
Neuroscience.

He became Chair of Neuroscience in 2000 and moved to National Institute on Aging, Bethesda,
Maryland, as Chief of the Laboratory of Neurogenetics in 2001. In 2007 he took up the Chair of
Molecular Biology of Neurological Disease at the Reta Lila Weston Institute of Neurological Studies,
University College London.

On 29 November 2015, he was awarded the Breakthrough Prize.

In 2018, Hardy, along with Christian Haass, Bart De Strooper and Michel Goedert, received the Brain
Prize for "groundbreaking research on the genetic and molecular basis of Alzheimer's disease."[10]

Awards and honours

Among other awards and honours, Hardy has won the Breakthrough Prize in Life Sciences for dissecting
the causes of Alzheimer's disease, Parkinson's disease and frontotemporal dementia; the MetLife prize for
research into Alzheimer's disease, and the Potamkin Prize for his work in describing the first genetic
mutations in the amyloid gene in Alzheimer's disease, in 1991. He was elected a Fellow of the Royal
Society (FRS) in 2009.[1] He was knighted in the 2022 New Year Honours for services to "human health
in improving our understanding of dementia and neurodegenerative diseases".[11]

2023 - Honorary Doctor of the University of Rijeka[12]

2023 - Foreign Member of the Chinese Academy of Sciences[13]
2022 New Year Honours
2022 - Mayo Clinic Distinguished Alumni Award[14]
2018 – The Brain Prize[15]
2017 – Honorary Doctor of Science, Leeds University[16]
2015 – Breakthrough Prize in Life Sciences[17]
2015 – Member of the European Molecular Biology Organization (EMBO)[18][19]
2014 – The Michael J. Fox Foundation award for Parkinson research[20]
2014 – Thudichum Medal from the Biochemical Society
2014 – Dan David Prize[21]
2011 – Elected Fellow of the Institute of Biology
2010 – Honorary Doctor of Science, Newcastle University
2009 – Elected Fellow of the Royal Society[1]
2008 – Honorary MD, Umeå University, Sweden,
2008 – Elected a Fellow of the Academy of Medical Sciences (FMedSci)[2]
2008 – Anne Marie Oprecht International Prize for Research in Parkinson's Disease
2002 – Kaul Prize for Research into Alzheimer's disease
1995 – Allied Signal Prize for Research into Aging
1994 – Metlife Foundation Award for Medical Research in Alzheimer's Disease[22]
1993 – Potamkin Prize from the American Academy of Neurology, for Alzheimer's Research
1992 – IPSEN Prize for Research into Alzheimer's Disease
1991 – Peter Debje Prize, University of Limburg, Belgium, For Alzheimer's Research

References
1. "Professor John Hardy FMedSci FRS" (https://web.archive.org/web/20151117105355/http
s://royalsociety.org/people/john-hardy-11582/). London: Royal Society. Archived from the
original (https://royalsociety.org/people/john-hardy-11582/) on 17 November 2015.
 2. "Professor John Hardy FRS FMedSci" (https://web.archive.org/web/20160802020616/http://
www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-john-hardy/).
Archived from the original (http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fello
ws/professor-john-hardy/) on 2 August 2016. Retrieved 27 November 2015.
3. "HARDY, Prof. John" (https://www.ukwhoswho.com/view/article/oupww/whoswho/U254852).
Who's Who. Vol. 2015 (online Oxford University Press ed.). A & C Black. (Subscription or UK
public library membership (https://www.ukwhoswho.com/page/subscribe#public) required.)
4. Hutton, Mike; Heutink, Peter; Lendon, Corinne L.; Rizzu, Patrizia; Baker, Matt; Froelich,
Susanne; Houlden, Henry; Pickering-Brown, Stuart; Chakraverty, Sumi; Isaacs, Adrian;
Grover, Andrew; Hackett, Jennifer; Adamson, Jennifer; Lincoln, Sarah; Dickson, Dennis;
Davies, Peter; Petersen, Ronald C.; Stevens, Martijn; de Graaff, Esther; Wauters, Erwin;
van Baren, Jeltje; Hillebrand, Marcel; Joosse, Marijke; Kwon, Jennifer M.; Nowotny, Petra;
Che, Lien Kuei; Norton, Joanne; Morris, John C.; Reed, Lee A.; Trojanowski, John; Basun,
Hans; Lannfelt, Lars; Neystat, Michael; Fahn, Stanley; Dark, Francis; Tannenberg, Tony;
Dodd, Peter R.; Hayward, Nick; Kwok, John B. J.; Schofield, Peter R.; Andreadis, Athena;
Snowden, Julie; Craufurd, David; Neary, David; Owen, Frank; Oostra, Ben A.; Hardy, John;
Goate, Alison; van Swieten, John; Mann, David; Lynch, Timothy (1998). "Association of
missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17". Nature.
393 (6686): 702–705. Bibcode:1998Natur.393..702H (https://ui.adsabs.harvard.edu/abs/199
8Natur.393..702H). doi:10.1038/31508 (https://doi.org/10.1038%2F31508). ISSN 0028-0836
(https://search.worldcat.org/issn/0028-0836). PMID 9641683 (https://pubmed.ncbi.nlm.nih.g
ov/9641683). S2CID 205001265 (https://api.semanticscholar.org/CorpusID:205001265).
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Fiona; Fidani, Liana; Giuffra, Luis; Haynes, Andrew; Irving, Nick; James, Louise; Mant,
Rebecca; Newton, Phillippa; Rooke, Karen; Roques, Penelope; Talbot, Chris; Pericak-
Vance, Margaret; Roses, Alien; Williamson, Robert; Rossor, Martin; Owen, Mike; Hardy,
John (1991). "Segregation of a missense mutation in the amyloid precursor protein gene
with familial Alzheimer's disease". Nature. 349 (6311): 704–706.
Bibcode:1991Natur.349..704G (https://ui.adsabs.harvard.edu/abs/1991Natur.349..704G).
doi:10.1038/349704a0 (https://doi.org/10.1038%2F349704a0). ISSN 0028-0836 (https://sea
rch.worldcat.org/issn/0028-0836). PMID 1671712 (https://pubmed.ncbi.nlm.nih.gov/167171
2). S2CID 4336069 (https://api.semanticscholar.org/CorpusID:4336069).
6. Hardy, J. (2002). "The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems
on the Road to Therapeutics". Science. 297 (5580): 353–356. Bibcode:2002Sci...297..353H
(https://ui.adsabs.harvard.edu/abs/2002Sci...297..353H). doi:10.1126/science.1072994 (http
s://doi.org/10.1126%2Fscience.1072994). ISSN 0036-8075 (https://search.worldcat.org/iss
n/0036-8075). PMID 12130773 (https://pubmed.ncbi.nlm.nih.gov/12130773).
S2CID 15150253 (https://api.semanticscholar.org/CorpusID:15150253).
7. Keegan (7 January 2022). "Old Boys News - New Year's Honours 2022" (https://www.st-am
brosecollege.org.uk/attachments/download.asp?file=2762&type=pdf). Saint Ambrose
College Weekly News Bulletin. p. 6. Retrieved 11 January 2022.
8. Neuroscience NIH (http://neuroscience.nih.gov/Lab.asp?Org_ID=436/) Archived (https://we
b.archive.org/web/20151210203140/http://neuroscience.nih.gov/Lab.asp?Org_ID=436%2F)
10 December 2015 at the Wayback Machine
9. HIH.gov (http://www.nia.nih.gov/NewsAndEvents/JohnHardyPhD.htm/) Archived (https://we
b.archive.org/web/20111105213913/http://www.nia.nih.gov/NewsAndEvents/JohnHardyPh
D.htm/) 5 November 2011 at the Wayback Machine
10. thebrainprize.org (http://www.thebrainprize.org/flx/prize_winners/the_brain_prize_winners_2
018/)
11. "No. 63571" (https://www.thegazette.co.uk/London/issue/63571/supplement/N2). The
London Gazette (Supplement). 1 January 2022. p. N2.
12. "Sir John Anthony Hardy honorary doctor of the University of Rijeka" (https://uniri.hr/en/vijest
i/sir-john-anthony-hardy-honorary-doctor-of-the-university-of-rijeka/). University of Rijeka. 18
September 2023. Retrieved 11 October 2022.
13. "Professor Sir John Hardy elected as Foreign Member of the Chinese Academy of
Sciences" (https://www.ucl.ac.uk/ion/news/2023/nov/professor-sir-john-hardy-elected-foreign
-member-chinese-academy-sciences-cas/). UCL Queen Square Institute of Neurology. 11
November 2023. Retrieved 3 December 2023.
14. "Mayo Clinic honors 6 with Distinguished Alumni Awards" (https://newsnetwork.mayoclinic.or
g/discussion/mayo-clinic-honors-6-with-distinguished-alumni-awards/). Mayo Clinic. 21
November 2022. Retrieved 11 October 2022.
15. Devlin, Hannah (6 March 2018). "Brain prize winner calls Brexit a 'disaster' for the NHS and
science" (https://www.theguardian.com/science/2018/mar/06/brain-prize-winner-calls-brexit-
a-disaster-for-the-nhs-and-science). The Guardian. Retrieved 2 May 2018.
16. "John Hardy" (https://www.leeds.ac.uk/info/130509/honorary_graduates/493/john_hardy).
Leeds University. July 2017. Retrieved 13 July 2017.
17. https://breakthroughprize.org/ Breakthrough Prize 2016
18. "The EMBO Pocket Directory" (https://web.archive.org/web/20150316002020/http://www.em
bo.org/documents/members/The_EMBO_Pocket_Directory.pdf) (PDF). European Molecular
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The_EMBO_Pocket_Directory.pd) on 16 March 2015.
19. "EMBO announces new members for 2015" (https://web.archive.org/web/20160321063845/
http://www.embo.org/news/press-releases/press-releases-2015/embo-announces-new-mem
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20. Pritzker, MJ Fox Award for Parkinson Research (https://www.michaeljfox.org/foundation/new
s-detail.php?leader-in-parkinson-genetics-research-honored-with-2015-robert-pritzker-prize)
21. "Dan David Prize: LAUREATES 2014: Combatting Memory Loss, JOHN A. HARDY" (http://
www.dandavidprize.org/laureates/2014/175-present-combatting-memory-loss/624-prof-john-
a-hardy).
22. "MetLife Foundation Awards for Medical Research in Alzheimer's Disease" (https://web.archi
ve.org/web/20181013093256/http://mlfawards.afar.org/docs/2016Edition_MetLifeFoundation
Awards_PastWinners.pdf) (PDF). Archived from the original (http://mlfawards.afar.org/docs/
2016Edition_MetLifeFoundationAwards_PastWinners.pdf) (PDF) on 13 October 2018.

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