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Lesson 15

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Lesson 15

Bipolar and Related Disorders

Topic 70-76

Topic 70: Bipolar Disorders

According to DSM 5, Bipolar disorders are a group of disorders that cause extreme fluctuation in
a person’s mood, energy, and ability to function. Such conditions feature extreme shifts in mood
and fluctuations in energy and activity levels. Previously known as manic depressive disorder, it
has been termed as Bipolar and Related Disorders in DSM 5.

Bipolar disorder is a category that includes three different conditions:

1. Bipolar I disorder
2. Bipolar II disorder
3. Cyclothymic disorder

If any of these disorders are left untreated, it can adversely affect relationships, undermine career
prospects, and has serious effect on academic performance. Moreover, in some cases, it can lead
to suicide. Diagnosis of these disorders most commonly occurs between the ages of 15 and 25
years, but it can happen at any age. It affects males and females equally.

In bipolar disorders, we have to know about three types of episodes:

• Manic Episode
• Hypomanic Episode
• Depressive Episode

Manic Episode

As opposed to depression, mania is the other pole of mood. A manic episode is not a disorder in
and of itself, but rather is diagnosed as a part of a condition called bipolar disorder. Individuals
in a state of mania typically experience dramatic and inappropriate rises in mood. The symptoms
of mania span the same areas of functioning i.e. emotional, motivational, behavioral, cognitive,

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and physical as those of depression, but mania affects those areas in an opposite way. A person
experiencing a manic episode is usually engaged in significant goal-directed activity beyond
their normal activities.

Distinctive Features

• The manic episode may have been preceded by and may be followed by hypomanic or
major depressive episodes.
• A distinct period of abnormally and persistently elevated, expansive, or irritable mood
• Abnormally and persistently increased activity or energy

Duration: Duration of the manic episode to be diagnosed must be 1 week and present most of
the day, nearly every day.

Topic 71: Diagnostic Criteria of Manic Episode

According to DSM-5, it is necessary to meet the following criteria for a manic episode.

A. A distinct period of abnormally and persistently elevated, expansive, or irritable mood and
abnormally and persistently increased goal-directed activity or energy, lasting at least 1
week and present most of the day, nearly every day (or any duration if hospitalization is
necessary).
B. During the period of mood disturbance and increased energy or activity, three (or more) of
the following symptoms (four if the mood is only irritable) are present to a significant
degree and represent a noticeable change from usual behavior:
1. Inflated self-esteem or grandiosity.
2. Decreased need for sleep (e.g., feels rested after only 3 hours of sleep).
3. More talkative than usual or pressure to keep talking.
4. Flight of ideas or subjective experience that thoughts are racing.
5. Distractibility (i.e., attention too easily drawn to unimportant or irrelevant external
stimuli), as reported or observed.
6. Increase in goal-directed activity (either socially, at work or school, or sexually) or
psychomotor agitation (i.e. purposeless non-goal-directed activity).

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7. Excessive involvement in activities that have a high potential for painful consequences
(e.g., engaging in unrestrained buying sprees, sexual indiscretions, or foolish business
investments).
C. The mood disturbance is sufficiently severe to cause marked impairment in social or
occupational functioning or to necessitate hospitalization to prevent harm to self or others, or
there are psychotic features.
D. The episode is not attributable to the physiological effects of a substance (e.g., a drug of
abuse, a medication, other treatment) or to another medical condition.

Topic 72: Hypomanic Episode

Hypo- comes from the Greek for “under”; hypomania is “under”, less extreme than, mania.
Although mania involves significant impairment, hypomania does not. Rather, hypomania
involves a change in functioning that does not cause serious problems. The person with
hypomania may feel more social, flirtatious, energized, and productive.

It is a distinct period of abnormally and persistently elevated, expansive, or irritable mood and
abnormally and persistently increased goal-directed activity or energy

Duration: Duration of the manic episode to be diagnosed must at least 4 consecutive days and
present most of the day, nearly every day.

Diagnostic Criteria

A. During the period of mood disturbance and increased energy and activity, three (or more) of
the following symptoms (four if the mood is only irritable) have persisted, represent a
noticeable change from usual behavior, and have been present to a significant degree:
1. Inflated self-esteem or grandiosity.
2. Decreased need for sleep (e.g., feels rested after only 3 hours of sleep).
3. More talkative than usual or pressure to keep talking.
4. Flight of ideas or subjective experience that thoughts are racing.
5. Distractibility (i.e., attention too easily drawn to unimportant or irrelevant external
stimuli), as reported or observed.

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6. Increase in goal-directed activity (either socially, at work or school, or sexually) or
psychomotor agitation.
7. Excessive involvement in activities that have a high potential for painful consequences
(e.g., engaging in unrestrained buying sprees, sexual indiscretions, or foolish business
investments).
B. The episode is associated with an unequivocal change in functioning that is uncharacteristic
of the individual when not symptomatic.
C. The disturbance in mood and the change in functioning are observable by others.
D. The episode is not severe enough to cause marked impairment in social or occupational
functioning or to necessitate hospitalization. If there are psychotic features, the episode is,
by definition, manic.
E. The episode is not attributable to the physiological effects of a substance (e.g., a drug of
abuse, a medication, other treatment).

Topic 73: Bipolar I Disorder

Bipolar I disorder is a manic-depressive disorder that can exist both with and without psychotic
episodes. A person affected by bipolar I disorder has had at least one manic episode in his or her
life. Most people with bipolar I disorder also suffer from episodes of depression. Often, there is a
pattern of cycling between mania and depression. In between episodes of mania and depression,
many people with bipolar I disorder can live normal lives.

Following is the diagnostic criteria of Bipolar I disorder according to DSM-5:

A. Criteria have been met for at least one manic episode


B. The occurrence of the manic and major depressive episode(s) is not better explained by
schizoaffective disorder, schizophrenia, schizophreniform disorder, delusional dis order, or
other specified or unspecified schizophrenia spectrum and other psychotic

Severity:

We need to specify the current severity of the disorder on the following:

• Mild

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• Moderate
• Severe

Specify:

While diagnosing bipolar disorder we need to specify if it is:

• Unspecified
• with psychotic features
• With anxious distress
• With mixed features
• With rapid cycling
• With melancholic features
• With mood-congruent psychotic features
• With mood-incongruent psychotic features
• With catatonia
• With péri-partum onset
• With seasonal pattern

Topic 74: Bipolar II Disorder

Bipolar II disorder is characterized by cycles of depressive episodes followed by hypomanic


periods. Bipolar II symptoms are very much similar with Bipolar I disorder but, in bipolar II,
elevated moods never reach full-blown mania. The less-intense elevated moods in bipolar II
disorder are called hypomanic episodes, or hypomania.

Diagnostic Criteria:

Following is the diagnostic criteria of Bipolar II disorder:

• Criteria have been met for at least one hypomanic episode and at least one major
depressive episode
• There has never been a manic episode.

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• The symptoms are not better explained by psychotic disorder or any other medical
condition
• The symptoms cause clinically significant distress or impairment in social, occupational,
or other important areas of functioning.

Specify:

We need to specify current or most recent episode as per the following phases:

• Hypomanic
• Depressed

It is also needed to be specified it is:

• With anxious distress


• With mixed features
• With rapid cycling
• With mood-congruent psychotic features
• With mood-incongruent psychotic features
• With catatonia
• With péri-partum onset
• With seasonal pattern

We also need to specify if the course if full criteria for a mood episode are not currently met:

• In partial remission
• In full remission

We need to specify the current severity of the disorder on the following:

• Mild
• Moderate
• Severe

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Topic 75: Cyclothymic Disorder

Cyclothymic disorder is a cyclic disorder that causes brief episodes of hypomania and
depression. It is diagnosed when symptoms are not sufficient to be a major depressive episode or
a hypomanic episode.

Following is the diagnostic criteria of Cyclothymic Disorder as per DSM 5:

A. For at least 2 years (at least 1 year in children and adolescents) there have been numerous
periods with hypomanic symptoms that do not meet criteria for a hypomanic episode and
numerous periods with depressive symptoms that do not meet criteria for a major depressive
episode.
B. During the above 2-year period (1 year in children and adolescents), the hypomanic and
depressive periods have been present for at least half the time and the individual has not
been without the symptoms for more than 2 months at a time.
C. Criteria for a major depressive, manic, or hypomanic episode have never been met.
D. The symptoms in Criterion A are not better explained by schizoaffective disorder,
schizophrenia, schizophreniform disorder, delusional disorder, or other specified or
unspecified schizophrenia spectrum and other psychotic disorder.
E. The symptoms are not attributable to the physiological effects of a substance (e.g., a drug of
abuse, a medication) or another medical condition (e.g., hyperthyroidism).
F. The symptoms cause clinically significant distress or impairment in social, occupational, or
other important areas of functioning.

Specify:

While diagnosing, it needs to be specified if it is:

• With anxious distress


• Substance/medication induced

Topic 76: Substance/Medication Induced Bipolar Disorder

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These disorders are classified as mania, hypomania or a major depressive episode directly caused
by a substance/medication. The symptoms must start during or soon after the
substance/medication was taken, or during withdrawal.

Following is the diagnostic criteria of Cyclothymic Disorder as per DSM 5:

A. A prominent and persistent disturbance in mood that predominates in the clinical picture and
is characterized by elevated, expansive, or irritable mood, with or without depressed mood,
or markedly diminished interest or pleasure in all, or almost all, activities.
B. There is evidence from the history, physical examination, or laboratory findings of both (1)
and (2):
1. The symptoms in Criterion A developed during or soon after substance intoxication or
withdrawal or after exposure to a medication.
2. The involved substance/medication is capable of producing the symptoms in Criterion A.
C. The disturbance is not better explained by a bipolar or related disorder that is not
substance/medication-induced. Such evidence of an independent bipolar or related disorder
could include the following:
• The symptoms precede the onset of the substance/medication use; the symptoms persist
for a substantial period of time (e.g., about 1 month) after the cessation of acute
withdrawal or severe intoxication; or there is other evidence suggesting the existence of
an independent non-substance/medication-induced bipolar and related disorder (e.g., a
history of recurrent non-substance/medication-related episodes).
D. The disturbance does not occur exclusively during the course of a delirium.
E. The disturbance causes clinically significant distress or impairment in social, occupational,
or other important areas of functioning.

Specify:

We need to specify the current severity of the disorder on the following parameters:

• With use disorder, mild


• With use disorder, moderate
• With use disorder, severe

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It also needs to be specified if:

• With onset during intoxication


• With onset during withdrawal

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