ORIGIN OF LIFE

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Atmosphere of the Primitive Earth

 Understanding the atmosphere of the

primitive Earth is crucial for studying the
origins of life, as it provided the necessary
conditions for chemical evolution and the
formation of organic molecules.
Formation of the Early Atmosphere

 Primordial Earth: The early Earth formed about

4.5 billion years ago. Initially, it had no
atmosphere, and its surface was molten due to
intense heat from accretion and frequent
impacts.
 Degassing of Volatiles: As the planet cooled,
volcanic outgassing released gases trapped in
the Earth's interior, forming the initial
atmosphere.
Composition of the Early
Atmosphere
 Reducing Atmosphere: The early atmosphere was likely reducing,
dominated by gases such as:
 Methane (CH₄)
 Ammonia (NH₃)
 Hydrogen (H₂)
 Water Vapor (H₂O)
 Lack of Free Oxygen: Free oxygen (O₂) was virtually absent, as it
would have reacted with other elements, maintaining a reducing
environment.
Sources of Atmospheric Gases

 Volcanic Activity: Volcanic eruptions released

large amounts of gases, including water vapor,
carbon dioxide (CO₂), sulfur compounds (SO₂,
H₂S), and nitrogen (N₂).
 Cometary and Meteoritic Contributions: Impacts
from comets and meteorites could have
delivered additional volatile compounds,
including water and organic molecules.
Energy Sources for Chemical
Reactions
 UV Radiation: The lack of an ozone layer allowed high
levels of ultraviolet (UV) radiation to reach the surface,
providing energy for chemical reactions.
 Electrical Discharges: Frequent lightning storms
generated by the highly active atmosphere could also
initiate chemical reactions.
 Geothermal Energy: Heat from volcanic activity and
hydrothermal vents provided localized energy sources
for chemical reactions.
Chemical Reactions in the Early
Atmosphere
 Formation of Organic Molecules: The reducing conditions and
abundant energy sources facilitated the synthesis of organic
molecules, such as:
 Amino acids
 Nucleotides
 Simple sugars
 Miller-Urey Experiment: Demonstrated that amino acids could form
under simulated early Earth conditions, supporting the hypothesis
that the primitive atmosphere could foster organic synthesis.
Evolution of the Atmosphere

 Photosynthesis and Oxygenation: The advent of

photosynthetic organisms, particularly cyanobacteria,
gradually increased atmospheric oxygen levels, leading
to the Great Oxidation Event (~2.4 billion years ago).
 Formation of the Ozone Layer: The increase in oxygen
allowed for the formation of the ozone (O₃) layer, which
reduced the influx of harmful UV radiation and enabled
more complex life forms to evolve.
Evidence from Geological Records

 Isotopic Analysis: Ratios of isotopes in ancient rocks

provide insights into the composition of the early
atmosphere.
 Microfossils and Stromatolites: Fossilized microbial
structures give clues about early life and its impact on
atmospheric composition.
Modern Research and Insights

 Simulation Experiments: Modern laboratory experiments

continue to explore the chemical processes that could
have occurred in the primitive atmosphere.
 Astrobiology: Studies of other planetary bodies and
moons inform our understanding of atmospheric
evolution and the potential for life elsewhere.
EARLY LIFE FORMS
 Significance: Studying early life forms helps us
understand the origin and evolution of life on Earth,
providing insights into the conditions that allowed life to
thrive and diversify
Earliest Evidence of Life

 Fossil Record: The oldest evidence of life dates back to around 3.5
to 3.8 billion years ago.
 Stromatolites: Layered structures formed by the activity of microbial
communities, primarily cyanobacteria.
 Microfossils: Microscopic fossils of ancient microorganisms found in
ancient rock formations.
 Isotopic Signatures: Isotopic ratios in ancient rocks indicate
biological activity, suggesting the presence of life.
Characteristics of Early Life Forms

 Prokaryotic Cells: The earliest life forms were prokaryotes, simple

single-celled organisms without a nucleus.
 Bacteria: One of the two main groups of prokaryotes.
 Archaea: Another group of prokaryotes, often found in extreme
environments.
 Anaerobic Metabolism: Early life forms likely relied on anaerobic
(non-oxygen-requiring) processes for energy, as the early Earth
lacked free oxygen.
Early Metabolic Pathways

 Chemoautotrophy: Early organisms may have used inorganic

molecules (e.g., hydrogen sulfide, ammonia) to produce energy.
 Photosynthesis: The development of photosynthesis allowed
organisms to harness sunlight for energy, producing oxygen as a
byproduct.
 Anoxygenic Photosynthesis: Early photosynthetic bacteria used light but
did not produce oxygen.
 Oxygenic Photosynthesis: Evolved in cyanobacteria, producing oxygen
and contributing to the Great Oxidation Event.
Evolution of Cellular Complexity

 Horizontal Gene Transfer: Early prokaryotes exchanged genetic

material, promoting genetic diversity and evolution.
 Endosymbiotic Theory: Proposes that eukaryotic cells (cells with a
nucleus) originated through symbiotic relationships between
primitive prokaryotic cells.
 Mitochondria: Originated from engulfed aerobic bacteria.
 Chloroplasts: Originated from engulfed photosynthetic bacteria.
The Great Oxidation Event

 Oxygen Accumulation: Around 2.4 billion years ago, oxygen levels in

the atmosphere began to rise significantly due to oxygenic
photosynthesis.
 Impact on Life: The increase in oxygen levels led to the extinction of
many anaerobic organisms and the evolution of aerobic respiration,
allowing for more efficient energy production.
Adaptation to Extreme
Environments
 Extremophiles: Early life forms that thrived in extreme conditions
(e.g., high temperatures, acidity, salinity).
 Thermophiles: Organisms that live in extremely hot environments, such as
hydrothermal vents.
 Halophiles: Organisms that thrive in high-salt environments.
Evidence from Modern Analogues

 Modern Microbial Mats: Present-day microbial mats in environments

like hot springs and salt flats provide insights into early life forms and
their ecological interactions.
 Stromatolites Today: Modern stromatolites, found in places like Shark
Bay, Australia, serve as analogues for ancient stromatolites.
The Role of Viruses

 Early Viral Evolution: Viruses may have played a role in early genetic
exchange and evolution, despite not being considered "alive"
themselves.
Chemical Basis and Evolution of Life
Forms Through Ages
Chemical Basis of the Origin of Life
 2. Early Earth Conditions
 Formation: Earth formed about 4.5 billion years ago.
 Atmosphere: Initially reducing, with gases like methane (CH₄),
ammonia (NH₃), hydrogen (H₂), and water vapor (H₂O).
 Energy Sources: UV radiation, lightning, volcanic activity, and
hydrothermal vents provided energy for chemical reactions.
Formation of Organic Molecules

 Miller-Urey Experiment (1953): Demonstrated that amino acids

could be synthesized from inorganic precursors under simulated
early Earth conditions.
 Prebiotic Chemistry: Organic molecules such as amino acids,
nucleotides, and lipids formed through natural processes.
Polymerization and Self-Replication

 Polymerization: Simple organic molecules polymerized to form

complex molecules like proteins and nucleic acids, facilitated by
mineral surfaces.
 RNA World Hypothesis: RNA was the first self-replicating molecule,
capable of storing genetic information and catalyzing chemical
reactions.
Formation of Protocells

 Lipid Vesicles: Amphiphilic molecules formed bilayer vesicles in

water, creating compartments similar to cell membranes.
 Protocells: These vesicles could encapsulate organic molecules,
providing a stable environment for further chemical evolution.
Evolution of Life Forms Through
Ages
Precambrian (4.6 billion - 541 million years ago)
 Origin of Life: First life forms appeared around 3.5 to 3.8 billion years
ago, evidenced by stromatolites and microfossils.
 Prokaryotes: Dominated early Earth, including bacteria and
archaea.
 Photosynthesis: Cyanobacteria developed oxygenic photosynthesis,
leading to the Great Oxidation Event (~2.4 billion years ago).
 Eukaryotes: Evolved around 2 billion years ago through
endosymbiosis (mitochondria and chloroplasts).
Paleozoic Era (541 - 252 million
years ago)
 Cambrian Explosion: Rapid diversification of multicellular life around
541 million years ago.
 Marine Life: Dominance of trilobites, brachiopods, and early
vertebrates.
 Colonization of Land: Plants, fungi, and arthropods began to
colonize land around 500 million years ago.
Mesozoic Era (252 - 66 million years
ago)
 Reptilian Dominance: Dinosaurs, pterosaurs, and marine reptiles
dominated.
 First Mammals and Birds: Mammals and birds evolved from reptilian
ancestors.
 Flowering Plants: Angiosperms appeared and diversified.
Cenozoic Era (66 million years ago
- Present)
 Mammalian Diversification: Mammals diversified rapidly after the
extinction of dinosaurs.
 Evolution of Primates: Primates evolved, leading to the emergence
of hominids.
 Human Evolution: Homo sapiens appeared around 300,000 years
ago, with significant developments in technology and culture.
Major Extinctions and Their Impact

 Ordovician-Silurian Extinction (445 million years ago)

 Late Devonian Extinction (375 million years ago)
 Permian-Triassic Extinction (252 million years ago)
 Triassic-Jurassic Extinction (201 million years ago)
 Cretaceous-Paleogene Extinction (66 million years ago)
 Impact on Evolution: Each mass extinction reshaped the biosphere,
allowing for the rise of new life forms.
CHEMICAL EVOLUTION

 Definition: The transition from non-living chemicals to living organisms

 Time period: Estimated 3.5-4 billion years ago on early Earth
 Key theories/hypotheses:
 RNA World
 RNA acted as both genetic material and catalyst
 Later transition to DNA and proteins
 Metabolism First
 Simple metabolic cycles emerged before replication
 Lipid World
 Self-replicating lipid vesicles as precursors to cells
 Panspermia
 Life originated elsewhere and was transported to Earth
Important concepts

 Chemical evolution
 Self-replication
 Encapsulation (protocells)
 Energy sources (e.g. hydrothermal vents)
 Building blocks (amino acids, nucleotides)
 Milestones

 Abiogenesis of organic molecules

 Formation of polymers
 Emergence of self-replicating systems
 Development of metabolism
 Encapsulation and protocell formation
 Evolution of genetic code and protein synthesis
 The chemical evolution theory of the origin of life, also known as
abiogenesis, posits that life emerged from non-living chemical
substances through a series of gradual and natural processes. Here
are detailed notes on this theory:
 Definition: Chemical evolution refers to the hypothesis that life
originated from simple chemical compounds on early Earth,
evolving into complex molecules and eventually living organisms.
 Stages of Chemical Evolution: The process can be broken down into
several key stages, including the formation of basic organic
molecules, the assembly of these molecules into polymers, and the
development of self-replicating systems and protocells.
 Early Earth Conditions

 Atmosphere: Early Earth's atmosphere likely contained gases such as

methane (CH₄), ammonia (NH₃), hydrogen (H₂), and water vapor
(H₂O), with little or no free oxygen (O₂).
 Energy Sources: Energy for chemical reactions was provided by
sources such as ultraviolet (UV) radiation from the Sun, lightning, and
volcanic activity.
Formation of Organic Molecules

 Miller-Urey Experiment: In 1953, Stanley Miller and Harold Urey

conducted an experiment simulating early Earth conditions. They
passed electrical sparks through a mixture of methane, ammonia,
hydrogen, and water vapor, resulting in the formation of amino
acids, the building blocks of proteins.
 Prebiotic Chemistry: Subsequent research has shown that other
organic molecules, including nucleotides (building blocks of nucleic
acids) and simple sugars, can form under similar conditions.
Polymerization

 Formation of Polymers: Simple organic molecules can polymerize to

form more complex molecules such as proteins, nucleic acids (RNA
and DNA), and polysaccharides. This process likely occurred on
mineral surfaces, such as clay, which can catalyze polymerization
reactions.
 Condensation Reactions: These reactions involve the joining of two
molecules with the loss of a small molecule, often water. They are
crucial for forming larger, more complex molecules from smaller
units.
Development of Self-Replicating
Systems
 RNA World Hypothesis: Proposes that RNA was the first self-
replicating molecule, capable of both storing genetic information
and catalyzing chemical reactions. RNA molecules known as
ribozymes can catalyze their own replication and other biochemical
reactions.
 Proto-RNA and Ribozymes: The discovery of ribozymes supports the
idea that RNA could have played a central role in early life forms,
eventually leading to the evolution of DNA and proteins.
Formation of Protocells

 Lipid Vesicles: Amphiphilic molecules, such as fatty acids, can

spontaneously form bilayer vesicles in water, creating
compartments that resemble cell membranes. These vesicles could
encapsulate organic molecules and provide a stable environment
for chemical reactions.
 Compartmentalization: Protocells would have provided a way to
concentrate reactants and maintain the conditions necessary for
biochemical reactions, a key step towards the development of true
cellular life.
Transition to Cellular Life

 Genetic Code: The development of a genetic code allowed for the

translation of nucleotide sequences into proteins, facilitating more
complex biochemical processes. This transition involved the
evolution of ribosomes and transfer RNAs (tRNAs).
 LUCA (Last Universal Common Ancestor): The most recent common
ancestor of all current life forms, believed to have been a simple,
single-celled organism with basic metabolic and genetic
machinery.
Supporting Evidence

 Fossil Record: Microfossils and stromatolites provide evidence for

early life, dating back over 3.5 billion years.
 Laboratory Experiments: Experiments simulating early Earth
conditions continue to demonstrate the plausibility of chemical
evolution, including the synthesis of complex organic molecules and
the formation of protocell-like structures.
Challenges and Open Questions

 Exact Pathways: The precise pathways and mechanisms through

which life emerged from non-living matter remain uncertain.
 Environmental Conditions: The specific conditions and environments
on early Earth that favored chemical evolution are still under
investigation.
 Self-Replication: Understanding how self-replicating molecules and
systems first arose is a key challenge.