RFAILURE

V V
LEFT SIDED & IGHT SIDED

·
Blood accumulates in
the lungs
mostcommon cause of'-

pUlmNARYEDE
①
⑰as A
RightheartFailure
↓

Leftheartfailure
Grossly: -

Wet, Bloggy
and Edemaions. ⑥ isolated at heart
②
microscopically.
-
(H2E) failure.
cells.
Heartfailure
we re are re ↓
seen in LUNGS

E
Amonary
·

HEART naemosidesin laden

Hypertension.
.

FAILURE macrophages.
CELLS stain:
special
-
C

organs effected:-
->

PRUSSIAN BLUE
of
Wecongested

-
PEARL STAIN. hepatomegaly

⑰EY: -Acutebe e
ensure

I
splenomegaly.

ofLiver
show: -
appearance
NUTMEG LIVER.
GAMMA GAND ' mem
BODIES. chronic venous
congestion ofriver.
 compared of:

3
-

Calcium
Hemoside in
Question
C) Fibrosis

·
Hemocidesin-Golden yellow or 4. Brown.
3 IRON OVERLOAD
nemosiderin
Lipofuscine ageing patient

↑
·

000
⑧

- >
Liver lost uniform

Browncanpeace ene
 ISCHEMIC HEART DISEASE

① Angina pectoris
-
Blood supply to
② MI

③ Sudden cardiac death

④ Chronic is chemic heartdisease.

Myocardial Infarction
Infart - area ofcoagulative necron's
↓
heart
in

Type ofInfarct

MONA.
V

subendo cardial Transmucal

only subendothelial zone

Infantpresentin all

effected
is 3
layers ofheart
leastperfuced zone)
·also kla ST segment
A -

elevation
Non-ST segment elevation Station
i
-

-
in fact

* Clinical Features:
SONAM
-

Achenpain radiating to left shoulder

*
·
nau vea

.
vomiting
 Adiaphoven's cenc, sweating)
*Dysphea. Hacks of Breath)

* INVESTIGATION:
-

ECG
⑰ nu

Transmural
① ST Seg Elevation
Infarct
-

⑦ Nonsi seg. Elevation - subendothelial infarct

③ I wave Inversion

④ Pathological G waves.

③
Cardiac Enzymes.
nee
a re

① MYOGLOBIN
-

carliestto 9 in m.1

·non-specific
in 24HR.
·
Rises in one hour, falls

Notgood for monitoring patient

② ABP (New updates

·
HeartFaity acid Binding Protein

·earliestto 9

③ CK-MB.

·
Rives in 2-4 hour

·
Falls in 2-3 days

->
I -> BEST MARKER
④ TROPOPIN
 in
Rises in falls 7-10
2.4 hours, Days.
NewtCHMB
·

QA. TROPOWIN I the

is belt Marker for REINFARCTION

⑤
LDH

norme.""""""""p

> - -
mite cell
swelling
Q -

④ archange >
Mito

- - Neutrophilis ·I

⑧
- - -

-
- -- "I

-macrophages
19

>We 1

- 1

11

↓
MORPIOLOGICAL CHANGES ofHEART in M. 1
 IDAY 3-YDAY L-LODAY

GranulathTissue
BV
Healed M. Infarct
wew

special stain for M1-> TTC - NEW

↑RIPHENYL TETRAZOLIUM CHLORIDE

paint the heart, MIC12HRdd.

Normal heart Necrotic area

Retains Dehydrogenare) How ofdehydrogenen

↓ ↓
BRICK Red Colour. Pale/yellow.
 Fitrat
8
area
- (Pale yellow)
NORMAL Triphenyl Tetrazolium
Chloride.

-
-> Normal area

(Brick Red)

A
complications of M1.
ACT-RAPID

A Aneunyem
C contractive
Dysfunction
T Thrombosis

qSHR - ventricullar
R Rupture

immias
tibrillation

A Arry supraventricular
->Inke
tachycardisit.
P papillary muscle dysfunction

I X
auto immune

- fibrinous
Pelicalitis.
D PRESSLER'S SYNDROME
 A IMP.
⑧ miesion re -
-

sudden T 82
in and Blood F10w.

cast ↑
Free Radicals
↓ ↓
hypercontracting myocyte
Muscle Fibres
Damage
↓ * AA
CONTRACTION
BAND NEUROSIS,

IMPORTANT
>CONTRACTION
0 BAND NECROSIS
un