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    Digitalis Lanata: By: Amjad Zyoud

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    Omer Kareem

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    Digitalis Lanata: By: Amjad Zyoud

    Uploaded by

    Omer Kareem
    35 views17 pages

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    35 views17 pages

    Digitalis Lanata: By: Amjad Zyoud

    Uploaded by

    Omer Kareem

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 17

    Digitalis Lanata

    By : Amjad Zyoud
    Scientific Name :
    Digitalis lanata Ehrh
    Scrophulariaceae
    ( Jakob Friedrich Ehrhart  1792)
    Common Name :
    Grecian Foxglove /or/ woolly
    foxglove
    Description
    •Digitalis is an evergreen  biennial or perennial herb that
    grows up to about 1.2 meters height.

    •Flower and Fruit: The inflorescence is long and densely


    flowers, with racemes facing all directions.

    •Digitalis lanata is native to Europe, now it is cultivated in


    Asia-Temperate, Western Asia and Europe. (1)
    Used part

    .The leaf is used as heart tonic 


    Plant constituents

    The main cardenolides of D. lanata are the lanatosides .


    (LanatosideA, LanatosideB and LanatosideC ) . (2)
    Uses

    Cardiac glycosides are important agents in the treatment of heart


    insufficiency. Cardiac glycosides are used in the treatment
    of congestive heart failure and cardiac arrhythmias. As yet, these
    drugs cannot be synthesized economically by chemical or
    microbiological methods. Hence they are extracted from plants, the
    most important source being Digitalis lanata . (3)
    Dose

    Digitalis leaf has a narrow therapeutic index, requiring close


    medical supervision for safe use. Traditional dosage starts at
    1.5 g of leaf divided into 2 daily doses. Purified digoxin is
    typically used at daily doses of 0.125 to 0.25 mg. (4)
    Contraindication (5)
    Adverse effects of digoxin

    Gastrointestinal : Anorexia / Nausea / Vomiting / Diarrhea / Abdominal pain.


    Central nervous system : Headache / Fatigue.
    Cardiac : Atrioventricular block / Ventricular ectopy. (6)
    Pregnancy

    Women on digoxin should tell their doctor if they are expecting or


    become pregnant. Digoxin is a pregnancy category "C" medicine,
    which means it’s unknown if the drug has any effect on pregnancy. (7)
    Clinical Study
    Clinical Study

    Conclusion: These findings favour targeting serum concentrations from 0.5 to 0.7
    ng/mL when dosing digoxin in patients with heart failure . (8)

    Conclusion: We found a significant in vivo correlation between SDC and platelet


    activation. In vitro study showed that supra-therapeutic digoxin concentrations
    increased platelet aggregation via calcium-related PLA2 phosphorylation. This
    finding provides new insights into the association between digoxin use and
    cardiovascular complications in AF patients. (9)
    Drug of digitalis in pharmacy

    DIGOXIN ®   LANOXIN ® 
    References :

    (1) Ali Esmail Al-Snafi, (2017),PHYTOCHEMICAL CONSTITUENTS AND MEDICINAL


    PROPERTIES OF DIGITALIS LANATA AND DIGITALIS PURPUREA- A REVIEW,4 (02),
    pages 225-234.

    (2) Kandzia R1, Grimm R, Eckerskorn C, Lindemann P, Luckner M. , (1998) Mar ,


    Purification and characterization of lanatoside 15'-O-acetylesterase from Digitalis lanata
    Ehrh;204(3):383-9.

    (3) Ursel Stuhiemmer 1, WolfgangKreis . Marina Eisenbeiss . andErnst Reinhard ,


    ( April, 1993 ). Cardiac Glycosides in Partly Submerged Shoots of Digitalis lanata Cardiac
    Glycosides in Partly Submerged Shoots of Digitalis lanata .

    (4) Grzegorz Grześk, Wioleta Stolarek, Michał Kasprzak, Marek Krzyżanowski, Katarzyna
    Szadujkis-Szadurska, Michał Wiciński, Elżbieta Grześk,b (2018 ) Therapeutic drug
    monitoring of digoxin–20 years of experience,Pharmacological Reports,Volume 70,
    Pages 184-189.
    (5) Anne P Spencer,(2003) , Digoxin in heart failure, Critical Care Nursing Clinics
    of North America, Volume 15, Issue 4, Pages 447-452 .

    (6) Anne P Spencer, (2003) , Digoxin in heart failure, Critical Care Nursing Clinics
    of North America, Volume 15, Issue 4, Pages 447-452 .

    (7) H. L. Tan and K. I. Lie ,(2001) , Treatment of tachyarrhythmias during


    pregnancy and lactation , (2001) , volume 22, 458–464.
    (8) Kirkwood F. Adams Jr1*, Javed Butler2, J. Herbert Patterson3, Wendy Gattis
    Stough4, Jerry L. Bauman5, Dirk J. van Veldhuisen6, Todd A. Schwartz7, Hani
    Sabbah8, John I. Mackowiak9, Hector O. Ventura10, and Jalal K. Ghali1 , (2016) ,
    Dose response characterization of the association of serum digoxin concentration
    with mortality outcomes in the Digitalis Investigation Group trial , 8, 1072–1081 .
    (9) Daniele Pastori, MD, PhD;* Roberto Carnevale, PhD;* Cristina Nocella, MSC;
    Simona Bartimoccia, MSC; Marta Novo, MSC; Vittoria Cammisotto, MSC; Silvia
    Piconese, PhD; Maria Santulli, MD; Fortunata Vasaturo, MD; Francesco Violi, MD;†
    Pasquale Pignatelli, MD, PhD;† Atherosclerosis in Atrial Fibrillation (ATHERO-F)
    Study Group‡ (2018) , Digoxin and Platelet Activation in Patients With Atrial
    Fibrillation: In Vivo and In Vitro Study .
    Thank you for listening to my presentation 

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