Aspirin and Other Salicylate Poisoning - Injuries
Aspirin and Other Salicylate Poisoning - Injuries
Aspirin and Other Salicylate Poisoning - Injuries
MSD MANUAL
Professional Version
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Salicylate poisoning can cause vomiting, tinnitus, confusion, hyperthermia, respiratory alkalosis, metabolic
acidosis, and multiple organ failure. Diagnosis is clinical, supplemented by measurement of the anion gap,
ABGs, and serum salicylate levels. Treatment is with activated charcoal and alkaline diuresis or
hemodialysis.
Pathophysiology
Salicylates impair cellular respiration by uncoupling oxidative phosphorylation. They stimulate respiratory centers in the
medulla, causing primary respiratory alkalosis, which is often unrecognized in young children. Salicylates simultaneously
and independently cause primary metabolic acidosis. Eventually, as salicylates disappear from the blood, enter the cells,
and poison mitochondria, metabolic acidosis becomes the primary acid-base abnormality.
Salicylate poisoning also causes ketosis, fever, and, even when systemic hypoglycemia is absent, low brain glucose levels.
Renal Na, K, and water loss and increased but imperceptible respiratory water loss due to hyperventilation lead to
dehydration.
Salicylates are weak acids that cross cell membranes relatively easily; thus, they are more toxic when blood pH is low.
Dehydration, hyperthermia, and chronic ingestion increase salicylate toxicity because they result in greater distribution of
salicylate to tissues. Excretion of salicylates increases when urine pH increases.
Diagnosis
Serum salicylate level
ABGs
Other findings compatible with sepsis (eg, fever, hypoxia, noncardiogenic pulmonary edema, dehydration,
hypotension)
If poisoning is suspected, serum salicylate level (drawn at least a few hours after ingestion), urine pH, ABGs, serum
electrolytes, serum creatinine, plasma glucose, and BUN are measured. If rhabdomyolysis is suspected, serum CK and
urine myoglobin are measured.
Significant salicylate toxicity is suggested by serum levels much higher than therapeutic (therapeutic range, 10 to 20
mg/dL), particularly 6 h after ingestion (when absorption is usually almost complete), and by acidemia plus ABG results
compatible with salicylate poisoning. Serum levels are helpful in confirming the diagnosis and may help guide therapy, but
levels may be misleading and should be clinically correlated.
Usually, ABGs show primary respiratory alkalosis during the first few hours after ingestion; later, they show compensated
metabolic acidosis or mixed metabolic acidosis/respiratory alkalosis. Eventually, usually as salicylate levels decrease,
poorly compensated or uncompensated metabolic acidosis is the primary finding. If respiratory failure occurs, ABGs
suggest combined metabolic and respiratory acidosis, and chest x-ray shows diffuse pulmonary infiltrates. Plasma glucose
levels may be normal, low, or high. Serial salicylate levels help determine whether absorption is continuing; ABGs and
serum electrolytes should always be determined simultaneously. Increased serum CK and urine myoglobin levels suggest
rhabdomyolysis.
Treatment
Activated charcoal
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Unless contraindicated (eg, by altered mental status), activated charcoal is given as soon as possible and, if bowel sounds
are present, may be repeated every 4 h until charcoal appears in the stool.
After volume and electrolyte abnormalities are corrected, alkaline diuresis can be used to increase urine pH, ideally to ≥ 8.
Alkaline diuresis is indicated for patients with any symptoms of poisoning and should not be delayed until salicylate levels
are determined. This intervention is usually safe and exponentially increases salicylate excretion. Because hypokalemia
may interfere with alkaline diuresis, patients are given a solution consisting of 1 L of 5% D/W, 3 50-mEq ampules of
NaHCO3, and 40 mEq of KCl at 1.5 to 2 times the maintenance IV fluid rate. Serum K is monitored. Because fluid overload
can result in pulmonary edema, patients are monitored for respiratory findings.
Drugs that increase urinary HCO3 (eg, acetazolamide) should be avoided because they worsen metabolic acidosis and
decrease blood pH. Drugs that decrease respiratory drive should be avoided if possible because they may impair
hyperventilation and respiratory alkalosis, decreasing blood pH.
Fever can be treated with physical measures such as external cooling. Seizures are treated with benzodiazepines. In
patients with rhabdomyolysis, adequate hydration and urine output are crucial; alkaline diuresis may also help prevent
renal failure.
Hemodialysis may be required to enhance salicylate elimination in patients with severe neurologic impairment, renal or
respiratory insufficiency, acidemia despite other measures, or very high serum salicylate levels (>100 mg/dL [> 7.25
mmol/L] with acute overdose or > 60 mg/dL [> 4.35 mmol/L] with chronic overdose).
Treating acid-base alterations in salicylate-poisoned patients who require endotracheal intubation and mechanical
ventilation for airway protection or oxygenation can be extremely challenging. In general, intubated patients should
probably be dialyzed and closely monitored by a critical care specialist.
Key Points
Salicylate poisoning causes respiratory alkalosis and, by an independent mechanism, metabolic acidosis.
Consider salicylate toxicity in patients with nonspecific findings (eg, alteration in mental status, metabolic
acidosis, noncardiogenic pulmonary edema, fever), even when a history of ingestion is lacking.
Treat with activated charcoal and alkaline diuresis with extra KCl.
© 2019 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA)
Respiratory Alkalosis
Respiratory alkalosis is a primary decrease in carbon dioxide partial pressure
(Pco2) with or without compensatory decrease in bicarbonate (HCO3−); pH
may be high or near normal. Cause is an increase in respiratory rate or
volume (hyperventilation)..read more
Metabolic Acidosis
Metabolic acidosis is primary reduction in bicarbonate (HCO3−), typically with
compensatory reduction in carbon dioxide partial pressure (Pco2); pH may be
markedly low or slightly subnormal. Metabolic acidoses are categorized as
high or normal..read more
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