BIO 101

Lecture 1

Introductory Biology
BIO-101

Amir Faisal

Introduction

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Overview

• Introduction to the course

• Why Study Biology

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Course Instructors

 Dr. Amir Faisal (lead)

 Dr. Muhammad Tariq
 Dr. Safee Ullah Chaudhary

 Head TAs:
 Salman Tuasene Khawaja [email protected]
 Paloma Maryam [email protected]

Tutorials can be organized with the Teaching Assistants

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Contact Information
Dr. Amir Faisal Dr Muhammad Tariq
SBASSE-Biology, Room 9-317A Email: [email protected]
Extension: 8453
Email: [email protected] Dr Safee Ullah Chaudhary
Email: [email protected]

Office Hours
Monday: 11:00 – 1:30 PM (or by appointment)

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Teaching Assistants

No. Names Roll Numbers

1 Salman Tuasene Khawaja [email protected]

2 Paloma Maryam [email protected]

3 Hamza Sajjad [email protected]

4 Muneeza Hassan [email protected]

5 Mahnoor Sakina Naqvi [email protected]

6 Nabeeha Fawad [email protected]

7 Khadija Badar [email protected]

8 Aleena Shahid Toor [email protected]

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Course Overview
Goal
 BIO101 is intended to provide students a broad overview of biology as it stands today!

Contents (to be covered in 5 modules)

 Macromolecules and Cell Biology
 Genes and Development
 Omics and Systems Biology
 Recombinant DNA Technology
 Human Diseases and Drug Discovery

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Lectures and Exam Schedule Lecture 1

DATE LECTURE TOPICS INSTRUCTOR READING MATERIAL

Lecture # MODULE-I: Macromolecules and Cell Biology
1 Biology: Life AF Chapter 1: p2-17
2 Molecules of Life I; Proteins AF Chapter 2: p22-51
Molecules of Life II; Carbohydrates, Lipids and Nucleic AF
3 Chapter 4: p51-66
Acids
4 Cell Structure AF Chapter 5: p77-118
5 Cell Communication AF Chapter 7: p126-140
6 Cell Cycle and Cell Division AF Chapter 11: p206-225
7 Generation and utilization of energy by cells AF Chapter 9 & 10: p165-200
EXAM-1 (covering lectures 1-7) February 12th, 2023
MODULE-2: Genes and Development
8 From DNA to Phenotype I-transcription MT Chapter 13: p260-288
9 From DNA to Phenotype II-translation MT Chapter 14; p290-300
10 From DNA to Phenotype III-translation MT Chapter 14; p290-300
11 Genetics I MT TBA
12 Genetics II MT TBA
13 Genetics III
14 Development I MT TBA
15 Development II MT TBA
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Lectures and Exam Schedule
DATE LECTURE TOPICS INSTRUCTOR READING MATERIAL
MODULE-3: The World of Omics
16 DNA & Protein Sequences SU Mount: Chapter 1, 2
17 Sequence Comparison SU Mount: Chapter 3
18 RNA & Protein Structures SU Rastogi: Chapter 1, 2
19 Structure Comparison SU Rastogi: Chapter 12
20 Computational Approaches to Structural Modelling SU Rastogi: Chapter 13
MODULE-4: Recombinant DNA and Genome editing
21 Recombinant DNA Technology -Cloning and Expression AF Chapter 18: p374-382
22 Genome Editing CRISPR – Cas9 AF
EXAM-3 (covering lectures 16-22) April 9 , 2023
th

MODULE-5: Human Diseases and Drug Discovery

24 Nervous system AF
Immune System AF Chapter 42: p856-875
25 Human Pathogens (Viruses and Bacteria) AF Chapter 26: p525-545
26 Cancer AF TBA
27 Drug Development & Delivery AF TBA
28 Biotechnology: Stem Cells and Personalized medicine AF TBA
EXAM-4 (covering lectures 24-28) May 8 , 2023
th

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Textbook
Life
The Science of Biology
10th Edition
Sadava
Hillis
Heller
Berenbaum

Copies of different editions are available in the library

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Other Resources
 Wikipedia, Google, etc

 http://www.ncbi.nlm.nih.gov/guide/literature/
- Bookshelf

 http://www.ncbi.nlm.nih.gov/pubmed/
- Home to electronic scientific journals

 http://www.ncbi.nlm.nih.gov/omim/
- Information about gene/protein function
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Study Aids

 Ask questions!

 See Instructors and TAs and during office hours

 Attend tutorials organized by TAs

 Study groups HIGHLY recommended

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Evaluation
 Exam-1 (Lectures 01-07; 12-02-23) 20%
 Exam-2 (Lectures 08-15; 12-03-23) 20%
 Exam-3 (Lectures 16-23; 09-04-23) 20%
 Exam-4 (Lectures 24-28; 08-05-23) 20%
 Attendance Quiz 10%
 Assignments 10%
Note
 All exam questions will be multiple choice
 Grading will be relative
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 B on mean
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Assignments

 Two assignments; one each before the Exam 2 and Exam 4

 40 random groups of 5 students each. Can be checked on LMS

 TAs will provide further information about the assignments

 All assignments to be submitted before Exams. Late submissions will not be

counted

 Each Assignment will be 5%

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Makeup Examinations

 Only under extreme circumstances

• Hospitalization
• Death in family
• Written evidence required
• Exam questions will be essay type

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Harassment Policy
SSE, LUMS and particularly this class, is a harassment free zone. There is absolutely zero tolerance for any
behaviour that is intended or has the expected result of making anyone uncomfortable and negatively impacts
the class environment, or any individual’s ability to work to the best of their potential.
If you think that you may be a victim of harassment, or if you have observed any harassment occurring in the
purview of this class, please reach out and speak to me. If you are a victim, I strongly encourage you to reach
out to the Office of Accessibility and Inclusion at [email protected] or the Sexual Harassment Inquiry
Committee at [email protected] for any queries, clarifications, or advice. You may choose to file an
informal or a formal complaint to put an end of offending behavior. You can find more details regarding the
LUMS sexual harassment policy here.
To file a complaint, please write to [email protected].

SSE’s Council on Belonging and Equity is committed to devising ways to provide a safe, inclusive and respectful
learning environment for students. [email protected]

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Student Code of Conduct
 Maintaining Decorum
• All members of the LUMS community share the responsibility to maintain a
comfortable and congenial environment at LUMS

 Appropriate Dress
• The dress should reflect decency and be according to cultural and social norms of
our society.
 Eating and Drinking
• Food and drinks, with the exception of water, are not allowed in the classroom,
discussion rooms, laboratories and the Library.
 Keeping the Campus Clean
• No littering on campus, inside or outside classroom.
 No Smoking
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Honor Code

ON OFF
 A student-teacher relationship is purely based on honesty, integrity and inspiration

 A student performs all academic work, assignments, exams, quizzes honestly and
never gets involved in any unfair activity falling under academic dishonesty like
cheating, unauthorized aid of any kind, plagiarism etc.

 Any instances of academic dishonesty in this course (intentional or unintentional) will

be dealt with swiftly and severely.
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Cheating

 Cheating on any exam will result in a score of zero for that exam

 Cheating on two exams will culminate in an automatic “F” in the

course and a report to DC

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What is Biology?
 Scientific study of living things (organisms)
 Common set of chemicals
 Cells are building blocks of organisms
 Cells convert molecules obtained from environment into new biological molecules
 Extract energy from the environment for the biological work
 Genetic information with universal genetic code to assemble proteins
 Similarities in fundamental set of genes
 Exist in populations, evolve through genetic variations over time
 Self regulate their internal environment – survive!

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Why Study Biology?

Health Food Study of

Environment
Basic Understanding Basic Understanding
Biofuels of human body of Plants

Study of pathogens Plant pathogens

and chronic diseases and diseases Synthetic
Biology
Biosensors Improving crop
Finding cures!
production

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Why Study Biology?

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Learning Outcomes
After this course students should be knowledgeable about:
 Features of different cell types
 How cells communicate with other cells
 Structure of genes and composition of genomes
 How biological information is stored and retrieved
 Modern approaches for probing informational databases and building
phylogenetic trees, etc
 What are pathogens and how immune system works
 How diseases occur and how they can be prevented or cured
 And much more!!!
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Development

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Animal and plant development
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Genetics

Genes, Genetics and Genomes

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From Genotype to Phenotype

Recessive = b Dominant = B

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Neuroscience

How the brain functions!

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Extremophiles

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Life in extreme environments
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Viruses

The Dangerous Underworld!

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Aging

Aging (& Disease)

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Immune System

E. coli K12 Macrophage attacking E. coli

Working of the Immune System

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Genetic Engineering

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Of Fireflies and Jellyfish

Mitotic spindles in fly embryo

Molecular Biology of the Cell 6th
Edition

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Personalized Genomics & Medicine

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Evolution

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