EU Graphene Flagship-Annual Report 2023
EU Graphene Flagship-Annual Report 2023
EU Graphene Flagship-Annual Report 2023
Report
2023
2 3
Contents
SPEARHEAD PROJECTS
2D EXPERIMENTAL PILOT LINE
12 2D-EPL: Creating an ecosystem for 2DM integration
GR APHENE F L AGSHIP ANNUAL REPORT 2023
ENERGY
26 ARMS
28 GRAPHERGIA
BIOMEDICAL
30 MUNASET
32 2D-BioPAD
COMPOSITES
42 GIANCE
2D MATERIALS OF TOMORROW
44 2D-PRINTABLE
46 2D ENGINE
48 2DSPIN-TECH
SAFE BY DESIGN
50 SAFARI
From the
(new) Director
T
HE LAST YEAR was nothing like any of the
preceeding years for the Graphene Flagship.
We celebrated the first ten years of the project
as we closed Core 3, and with it the single-pro-
ject structure of the Flagship. The five-day final
review and the broader assessment of the past
decade meant a lot of hard work by many. In the
end, I think we can proudly say that we have
delivered beyond expectations and given European tax-payers
extremely good value for their money. It was not a true ending,
but nevertheless a feeling of departure for many in the
community – the end of the Graphene Flagship as we knew it.
NEW HORIZONS
The past year was also a bright new beginning – the existing
GR APHENE F L AGSHIP ANNUAL REPORT 2023
COLLABORATIONS
During 2024 we will see our community re-form and gather
strength. One particularly important avenue, apart from the
Graphene Flagship itself and our Graphene Week conference in
Prague in October, will be the Innovative Advanced Materials for
Europe partnership. This partnership, drafted with a lot of input
and background from our community, is now an official “candi-
date partnership” in the Second Horizon Europe Strategic Plan.
Indeed, looking a bit broader, there are three strategic orienta-
tions made therein by the European Commission (EC): the green
transition, the digital transition, and a more resilient, competi-
tive, inclusive and democratic Europe. For all of these, the EC
stresses that securing Europe’s leading role in developing and
deploying critical technologies is an overarching principle. I’m
sure this is something we all can agree to work towards beyond
2024 and even beyond Horizon Europe.
Patrik Johansson
Passing the baton: Former Graphene Director Graphene Flagship Director
Jari Kinaret (right) congratulates current
Graphene Flagship Director Patrik Johansson
on a successful Graphene Week 2023 in
Gothenburg, Sweden.
6 ABOUT GRAPHENE FLAGSHIP ABOUT GRAPHENE FLAGSHIP 7
The Graphene
Finally, Horizon Europe will create jobs, fully engage the
EU’s talent pool, boost economic growth, promote industrial
competitiveness and optimise investment impact within a
B
technology, bringing positive changes that benefit society and
the economy and advance European leadership in technology
and industry. A decade on, we are proud to say that the Graphene Flagship
GrapheneEU
UILDING ON A DECADE of success, the “I’m excited to see the 2D materials community in Europe Graphene Flagship has delivered on its promise. The clearly
Graphene Flagship has now continued its continue to grow with the launch of the new Horizon Europe achieved objectives within scientific excellence, as well as Electronics Composites
journey under the European Commission’s projects. It will be interesting to see the new ideas that come societal and economic impact are detailed in the report, and Photonics GIANCE
Horizon Europe funding programme. In 2023 from this latest European investment in graphene and other Ten years of research, innovation and collaboration: the GATEPOST
2DNeuralVision
the single project that had sailed through the 2D materials,” Johansson says. Graphene Flagship and the 2DM community. Next-2DIGITS
EC’s FP7 and Horizon 2020 programmes
crossed the finish line with a series of cele- Energy
brations of its remarkable results in terms of HORIZON EUROPE MEETING NEW CHALLENGES ARMS
GRAPHERGIA
research outputs and commercialisation success. In October, The Graphene Flagship is funded by the European Commis- Despite changes in our funding structure and the make up
the Flagship split into a fleet of separately funded projects. sion’s Horizon Europe research and innovation programme of our community, the Graphene Flagship’s core mission to M EET THE NEW FLAGSHIP
(see page 18), which puts a strong emphasis on tackling commercialise graphene remains unchanged. From sensors
GR APHENE F L AGSHIP ANNUAL REPORT 2023
and 2D materials
create novel light-emitting
devices.
in photonics:
A revolutionary
I
leap in technology
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2D-EPL Creating
transfer tool for the de-bonding of the 2D layer from the growth
substrate to a rigid carrier from SUSS MicroTec.
an ecosystem for
Both of these tools have been installed in the imec cleanroom.
The availability of these unique tools allow us to take the next
step forward in the set-up of mature modules for 2D-material
growth and layer transfer: both are essential modules in
2DM integration
establishing pilot-line process capability.
LOOKING AHEAD
“In this last year of the project, it’s really our ambition to go in
T
a full sequence through using the new tooling from growth to
transfer and use the lessons we have learned thus far on the
integration flow,” says Inge Asselberghs, director of the 2D
he 2D Experimental Pilot Line (2D-EPL), now in Experimental Pilot Line. “We are also looking forward to seeing
its fourth and final year, is a €20 million project the final outcomes of the MPW runs and how we can build on
launched to address the challenges of upscal- this project’s foundation in the future.”
ing 2D material production processes for the
semiconductor industry. The project helps
create a European ecosystem for the integra-
tion of 2D materials in applications like 2D-EPL Horizon Europe
sensors, electronics and photonics. Projects
Graphene
At this stage, the project is mostly on track, having achieved Flagship
some important checkpoints in creating new processes and
modules for the generic integration flow. In parallel, the 2D-EPL
GR APHENE F L AGSHIP ANNUAL REPORT 2023
market.
Wafer Wafer
Scale Scale
Growth WORK PACKAGE LEADER
Transfer WORK PACKAGE LEADER
Michael Heuken, AIXTRON, Germany Steven Brems, imec, Belgium
Wafer Modules
Scale for the
Integration WORK PACKAGE LEADER
Industry WORK PACKAGE LEADER
Miika Soikkeli, VTT Technical Research Daniel Neumaier, AMO GmbH, Germany
Centre of Finland, Finland
DEVELOPING PROCESSES LAUNCHING THE MULTI-PROJECT WAFER RUNS
The main goal of the 2D Experimental Pilot Line’s Wafer Scale The main goal of the 2D Experimental Pilot Line’s (2D-EPL) WORK PACKAGE DEPUTY
Integration Work Package is to develop mature fabrication WORK PACKAGE DEPUTY Modules for the Industry Work Package is to deliver process Olli-Pekka Kilpi, VTT Technical Research
processes for graphene- and TMDC-based devices including Mindaugas Lukosius, IHP – Leibniz Institute modules, which can be adopted by different semiconductor Centre of Finland, Finland
the contacting, patterning, dielectrics, interface optimisation for high Performance Microelectronics, Germany manufacturers with only minimal changes for their specific
and passivation. The quality of the devices is closely monitored needs. In addition, by delivering multi-project wafer (MPW)
with the established quality control protocols to ensure that the runs, the Work Package provides a cost-efficient solution to
devices meet the expected criteria. smaller companies and universities to perform experiments NEW HORIZONS
on state-of-the-art graphene-based sensor devices. This In the Horizon Europe funding cycle, several projects on 2D
significantly reduces the entry barrier for testing new concepts materials related to sensors, electronics and photonics have
THIS YEAR’S PROGRESS based on an established technology. been funded. For most of these projects there is already an
The processes developed by the Work Package over the past related to functionalisation in the biosensing application area. existing link between the partners involved in these projects
GR APHENE F L AGSHIP ANNUAL REPORT 2023
2D 2D-EPL
Pilot Line Management
PAVING THE WAY FOR PILOT LINE DEVELOPMENT COORDINATING
The 2D Pilot Line Work Package supports the 2D Experimental WORK PACKAGE LEADER The Management Work Package ensures that the 2D Experi- WORK PACKAGE LEADER
Pilot Line’s (2D-EPL) development. From defining the multi- Inge Asselberghs, imec, Belgium mental Pilot Line (2D-EPL) project runs efficiently. It coordi- Patrik Johansson, Chalmers University of
project wafer (MPW) runs and disseminating the results of the nates the project and facilitates the 2D-EPL’s interactions and Technology, Sweden
project to creating a business model that will shape the future collaborations with the Graphene Flagship’s Core project, with
of the Pilot Line, this work package lays the groundwork for WORK PACKAGE DEPUTY Horizon Europe projects, and with the European Commission.
success. Max Lemme, AMO GmbH, Germany WORK PACKAGE DEPUTY
Maria Recaman Payo, imec, Belgium
THIS YEAR’S PROGRESS
THIS YEAR’S PROGRESS
With the end of the Graphene Flagship’s Core 3 project in
Over the past year the focus has been on maturing the September 2023, the Management Work Package worked to
2D-EPL’s offerings. Two multi-project wafer (MPW) runs were create a smaller, more streamlined governance structure which
organised, building on the experience of the previous year’s is more appropriate to a 12-partner project. The Graphene
work. The 2D-EPL’s third run, delivered by AMO, was intended Flagship’s Management Panel and Strategic Advisory Board
for electronics and leveraged the experience from the first run were dissolved, and the roles of the Executive Board and
effectively enough to be delivered early. The fourth run, by General Assembly were redefined. The new Executive Board is MEETING NEW CHALLENGES
GR APHENE F L AGSHIP ANNUAL REPORT 2023
Europe
responsive” ecosystem, one with “new economic opportuni- NEXT: HORIZON EUROPE
ties” and larger “more rapid deployment” thus “reinforcing The ambitious EU research and innovation
EU resilience and open strategic autonomy.”4 framework programme (2021–2027)
in the Lead
taking investment and translating it into a wealth of knowledge,
including thousands of peer-reviewed articles and hundreds of
marketable products, the “graphene gold-rush” and the impact
of the project’s investment will be hard to assess until
approximately 15-years after its completion. Kari Hjelt, the
Graphene Flagship’s head of innovation, says that is how long
I
the path is from research to commercialisation.5 It has been Science & technology
noted that while the EU has funded R&I heavily, the commercial Fuel EU’s scientific and technological
conversion has fallen behind, with shortcomings when it comes excellence and the strengthen the
to venture capital and infrastructure support; some of which European Research Area (ERA)
can be attributed to production challenges, funding gaps and
competition from China and the United States.6
GrapheneEU
Ensuring coordination, collaboration and
cooperation in the Graphene Flagship
T
HE GRAPHENE EUROPE in the Lead (Graphe- GrapheneEU will help PROJECT COORDINATOR
neEU) Coordination and Support Action (CSA) Patrik Johansson,
ensures the overall coherence of the Graphene secure a sustained Chalmers University of Technology
Flagship. Building on ten years of experience European leadership in 2DM by
providing central support and coordination to
the Graphene Flagship, the GrapheneEU project
capitalising on the past decade’s PARTNERS
partners will help to unite the new Horizon investments in the Graphene Chalmers University of Technology,
Europe Research and Innovation Actions (RIAs) Sweden
and Innovation Action (IA) and provide services to help increase
Flagship. Chalmers Industriteknik, Sweden
the initiative’s visibility, effectiveness and voice. European Science Foundation, France
University of Cambridge, United Kingdom
The CSA’s primary function is to encourage collaborations and Fraunhofer Institute for Systems and
knowledge transfer between the RIA/IA projects and with the studies. The CSA will build on the past roadmapping success, Innovation Research ISI, Germany
broader 2D materials (2DM) community. GrapheneEU ensures working jointly with the RIAs/IA to create field-specific road- Bundesanstalt für Materialforschung
a strong and coherent initiative by providing key support maps based on their technical and scientific input. und – prüfung (BAM), Germany
GR APHENE F L AGSHIP ANNUAL REPORT 2023
Innovation
COORDINATION AND GOVERNANCE To maximize their utilisation potential the RIAs/IA will be guided
GrapheneEU’s management in conjunction with the Graphene by the CSA’s innovation support to extend beyond European
Flagship Director help coordinate the initiative, bring the pro- industries and the Graphene Flagship. Past experience in
jects together to make strategic decisions and influence the industrial outreach, business development for 2DM technolo-
European research and innovation landscape for 2DM. The gies and hosting innovation events will help to strengthen the Sofia Öiseth will continue to coordinate the Innovation
Forum at Graphene Week, forwarding GrapheneEU’s
CSA monitors specific aspects of the RIAs/IA’s progress, impact of these activities. Industrialisation and Dissemination goals.
increases internal cohesion of the initiative by organising Credit: Graphene Flagship
strategic meetings, supports the RIA/IA coordinators regarding
EC regulations and requests and handles contacts with other DISSEMINATION
key stakeholders. GrapheneEU ensures that the work of the Graphene Flagship
is communicated to all stakeholders from the research and
The Graphene Flagship governance structure relies on one innovation community to decision-makers and the public.
common decision-making body, the Coordination Board, which Sharing a common message and combined voice ensures
includes the coordinators of the RIAs/IA as well as repre- greater visibility and impact for all the Graphene Flagship
sentatives of GrapheneEU. In this way the projects are kept projects. Coordination of individual messages will help ensure
appraised of the work being done inside the initiative and are collaboration rather than competition in reaching the various
encouraged to collaborate and contribute to broader activities. communication channels. This begins with a common website ALIGNMENT AND INTERNATIONAL COLLABORATIONS
and events calendar, helping the Graphene Flagship to remain Collaboration and knowledge transfer are key to the Graphene GrapheneEU is also establishing a strategic network of national
the single-entry point for news and information about graphene Flagship’s success. GrapheneEU will continue the past work on and thematic representatives to facilitate the interactions and
INDUSTRIALISATION and 2DM. international collaborations and alignment with national and exchange of information between the Graphene Flagship and
Industrialisation support is a key element in maximising the regional initiatives in Europe. The 2DM research community in other national, regional and thematic initiatives. Moreover, as
impact of the Graphene Flagship in terms of new products, The continuation of the popular Graphene Week conference Europe is comprised of over 1500 institutions actively working a result of the Graphene Flagship’s excellent research activities
companies and jobs in Europe. On this matter, GrapheneEU which allows for networking and knowledge transfer in all areas in the field, with over 150 European companies involved in and demonstrated scientific impact over the last ten years,
partners collaborate with the RIAs/IA through three interlinked of 2DM as well as digital workshops on more targeted topics various segments of the market (materials production, product Europe is recognised as a 2DM leader. This position has made
tasks: roadmapping, standardisation and innovation support. will be key to the collaborative dissemination efforts of the development, equipment manufacturing, etc.). While part of the the initiative an attractive global collaboration partner, a
The continuity of the Graphene Flagship partners working on Graphene Flagship. The RIAs/IA will contribute with speakers, research activities will be covered by the RIA/IA projects, a position that the CSA will continue to strengthen through a
industrialisation will facilitate early adoption and growth. strategic leadership and expertise to the conference, while the larger number of research activities will be supported at the series of international workshops that will address topics of
event will provide an avenue for collaboration and cooperation. national level or through other EU funding programmes. The interest to individual actors as well as international partners.
Roadmapping The Graphene Flagship’s established educational programmes CSA provides an interface for these activities, so that they can
Technology and Innovation Roadmaps identify the areas where and workshops and the Diversity in Graphene networking and all contribute to the Graphene Flagship and its objectives. This
new 2DM technologies can make the most significant impact coaching events continue to support the next generation, with will be achieved by offering the possibility for organisations or
on society, the economy and the environment using a highly a particular focus on underrepresented groups within the projects to join the initiative as Associated Members or
successful combination of workshops, interviews and literature 2DM community. Partnering Projects.
22 SUSTAINABILITY SUSTAINABILITY 23
Flash Graphene:
PLASTICS
The problem of plastic is familiar to anyone visiting the grocery Graphene Flagship Associated Member
Nanografen is producing graphene from
store or an open beach. It is everywhere and inescapable. waste tyres with the goal of improving
Trash to Treasure
recycling systems and making cars more
Plastics are made of polymetric materials and are used in many eco-friendly. Credit: Nanografen
indispensable applications throughout our daily lives, but their
long-decomposition time has left the unsolved problem of trash
in its wake. Although some plastics can be recycled, most end
up in landfills or floating in our seas, taking hundreds (if not
thousands) of years to decompose.
T
Since the Rice University discovery of FG, some have begun to
ponder and test whether the conversion of plastic waste (PW)
to graphene could be an answer to overcoming this immense
HE APPLICATIONS for graphene use are broad, Most conventional production problem.
having altered the composition of electronics,
energy storage and biomedical devices, methods include high energy
One approach to upcycling PW relies on FJH to convert PW to
sensors and composites and coatings over use and chemical leakage. As the FG. According to findings in an ACS (2020) article, “to make
the past two decades. This is all due to its
exceptional mechanical, electrical and ther- production of graphene-related high-quality graphene, a sequential alternating current (AC) and
mal properties. However, what are the environ- materials (GRM) continues to scale, direct current (DC) flash is used. The FJH process requires no
mental impacts of its use and how does the cost limit its catalyst and works for PW mixtures, which makes the process
application?
they will inevitably leak into our soil and suitable for handling landfill PW.” The authors also suggest that
waterways, therefore we must form an not only could FJH manage PW from landfill, but that the energy
Graphene was first isolated in 2004, and since then the cost required “is ≈23 kJ/g or ≈$125 in electricity per ton of PW,
informed understanding of what this potentially making this process economically attractive.” 9
has come down significantly. However, this is still dependent
on the quality of the graphene desired, and the production means for the environment and health
Another promising use for PW could be to produce not only However, according to a One Earth (2022) article “the sustaina-
methods used to isolate it. Commercial-grade, high-quality of the impacted ecosystems”.
GR APHENE F L AGSHIP ANNUAL REPORT 2023
ARMS
Eco-friendly supercapacitors
T
HE ARMS PROJECT, short for Atomic layer-coat- One key innovation within ARMS NEW HORIZONS
ed gRaphene electrode-based Micro-flexible Over the next few years, the ARMS project has an ambitious
and Structural supercapacitors, aims to create is the use of scalable atomic roadmap encompassing various crucial activities. In the first
environmentally-friendly supercapacitors with layer deposition (ALD) processes to modify year, the baseline synthesis parameters for both bio-graphene
high energy density (>50 Wh/kg), similar to and wood-derived carbon nanomaterials will be established,
batteries. By incorporating graphene-rich graphene-rich activated carbon electrodes
laying the groundwork for subsequent research. Concurrently,
bio-based carbon materials and graphene- by applying ultrathin conformal coatings benchmark and test procedures will be developed to evaluate
decorated carbon fibres and utilising scalable
and cost-effective atomic layer deposition (ALD) manufacturing
of metal oxides at the nanoscale, electrode performance in hybrid electrolyte systems. Later,
the focus will shift towards providing feedback on electrolyte
technology, the project seeks to maintain power density, cycle promising a major increase in energy interactions and presenting a Systems Safety by Design (SSbD) The ARMS project team.
Credit: ARMS
life and eco-friendliness. The ultimate goal is to establish a
density. These electrodes are designed framework report outlining criteria for safety, sustainability and
new value chain for supercapacitor manufacturing, with circularity assessments.
European small and medium-sized enterprises (SMEs) playing to offer high power density and long
a key role in this innovative initiative. cycle life, addressing the limitations Executing the ARMS project’s roadmap faces challenges in The ARMS project will contribute to the Graphene Flagship
GR APHENE F L AGSHIP ANNUAL REPORT 2023
T
dual focus on represents a
paradigm shift in the graphene industry,
HE GRAPHERGIA project seeks to transform
energy solutions with sustainable, efficient promising scalable and sustainable Advanced graphene-
power technologies. It focuses on developing advancements that will shape the future based LIB module for
space applications.
eco-friendly dry electrode fabrication for energy
storage devices, leveraging the potential of of energy storage and smart textiles.”
lasers in graphene synthesis. The project’s
ambition is two-fold: it will create self-charging Spyros Yannopoulos
e-textiles for biomechanical energy harvesting, Project Coordinator
making the charge-as-you-go lifestyle a reality for everyone. In
parallel, it aims to develop cost-effective lithium-ion batteries The GRAPHERGIA team.
(LIBs) for space applications, marking a significant step Credit: GRAPHERGIA
GR APHENE F L AGSHIP ANNUAL REPORT 2023
MUNASET
Multiparametric nanoelectronic
biosensors for therapy response testing
M
project is to develop graphene-
based devices to help doctors monitor
UNASET will develop a highly sensitive
graphene-based biosensor platform to the therapy of patients with depression
The project’s month six meeting took place in
diagnose neurological and psychiatric and other psychiatric disorders. The Zweibruecken on 29 February 2024. Credit: MUNASET
diseases.
envisioned test is fast, easy-to-use, only
MEETING NEW CHALLENGES requires blood samples and can be
Proteases recently emerged as a
promising new class of biomarker with
used at the point-of-care to develop
a broad diagnostic, prognostic and therapeutic potential for personalised therapies. It can greatly NEW HORIZONS
different human diseases including neurological and psychi- The project starts at technology readiness level (TRL) 3. In
improve the treatment outcomes for previous work by MUNASET partners and other researchers,
atric diseases, several types of cancer and immune system
GR APHENE F L AGSHIP ANNUAL REPORT 2023
response prediction along treatment of major depressive was characterised for clinically relevant analyte in different
disorder (MDD). MDD is one of the most common and burden- media, including buffer and serum.
some mental disorders worldwide. MDD is also among the • A CMOS readout was already fabricated, and its function
most expensive brain diseases in Europe. While effective • A novel field-effect sensing mechanism based on specific demonstrated in liquid without chemical functionalisation.
treatments exist, there is a high variability in treatment charge removal by proteases to ensure high and homogene- In the next two years, MUNASET will reach TRL 4. Detection
response. There are no serum-based tests to predict perso- ous signals. of purified protease in buffer using peptide-coated graphene
nalised therapy for MDD patients. The effective treatment is • An integrated complementary metal-oxide semiconductor biosensors will be validated in a lab environment.
identified through trial and error, a great burden for patients (CMOS) readout to enable robust multi-analyte measure-
and the health care system. ments with built-in calibration, averaging, etc. Point-of-care devices testing blood or serum samples often
suffer from the complexity of the analyte solution. In the
MUNASET will develop a rapid, highly sensitive and easy-to- MUNASET project a novel approach for the detection of
use graphene-based biosensor platform to address therapy SUSTAINABLE SOLUTIONS proteases in serum is being investigated, offering a highly
response prediction and allow faster and more precise MUNASET will contribute to a more sustainable industry sensitive and selective method to detect active proteases in Biomedical
treatment identification, improve therapy outcomes and reduce because the same underlying technology could be used in complex samples. The integration of highly sensitive devices
hospitalisation time. MUNASET will also help secure Europe’s different industries and application scenarios. The platform will with integrated electrical readout, as well as a microfluidic
industrial leadership over the entire value chain of novel integration ensures that the previous limitations in the field PROJECT COORDINATOR
also be miniaturised and have multi-analyte detection capabili-
graphene-based bio-analytical tools. ty on a single small chip, which will save materials and can be overcome. Alexey Tarasov, Kaiserslautern University of
resources needed to perform the tests. Applied Sciences, Germany
Our goal is a next-generation biosensor platform technology
that combines several existing technologies into a unique The project aims to further the United Nation’s Sustainable COLLABORATIONS
biosensor device that can potentially revolutionise the way Through interactions within the Graphene Flagship ecosystem, PARTNERS
Development Goal (SDG) for health and well-being. Not only will
biochemical reactions and physiological interactions are the developed platform be used for MDD patients to improve we anticipate a higher impact for our research, enabled by Kaiserslautern University of Applied Sciences,
studied. If successful, we expect that the resulting platform the therapy and monitor its effectiveness, but the platform will discussions leading to new scientific insights, new project Germany
technology will significantly advance biomedical research and also give valuable insight into the development of point-of-care ideas and collaboration opportunities; in addition to, access Graphenea Semiconductor SL, Spain
permit the development of novel point-of-care diagnostic and devices for multiple other diseases such as cancer. to various tools and knowledge from the GrapheneEU Coordina- Johannes Gutenberg University Mainz,
drug screening tools that can provide a competitive advantage tion and Support Action. Germany
for the healthcare and wellbeing sector in the European Union The MUNASET project is working to simplify the therapy VTT Technical Research Centre of Finland Ltd.,
(EU). process associated with MDD. This approach will reduce the Contribution to the Graphene Flagship initiative will be an Finland
number of resources used in classical therapies. Not only will essential goal of MUNASET, with four tasks articulating our Mainz University Medical Centre, Germany
By using 2D graphene, we plan to demonstrate the following the use of the MUNASET devices reduce the time spent at commitment and involvement. As such MUNASET will be able ProActive Ltd., Belgium
advantages compared to conventional tools: clinics, but it will also reduce the amount of medication that is to participate in the activities, contribute technical expertise,
• Improved biosensing performance; including low detection being used and streamline the tests that must be performed provide key exploitation results and report overall indicators
limits, low drift, high chemical stability and biocompatibility in a laborious way in standard laboratories. assessment to the new GrapheneEU CSA.
to allow sensitive and selective biomarker detection in real
time.
• Versatile surface chemistry via pi stacking of linker mole-
Having initiated synergies with both the Graphene Flagship and
other biomedical-oriented projects and initiatives, such as the
MUNASET
PART OF THE GRAPHENE FLAGSHIP
cules on graphene to attach capture peptides for different sister project 2D-BioPAD, MUNASET expects to contribute via
analytes. tangible actions and activities for promoting graphene bio-
medical research and innovation within and beyond the
Graphene Flagship ecosystem.
32 BIOMEDICAL BIOMEDICAL 33
2D-BioPAD
A supple graphene bio-platform for point-
of-care early detection and monitoring of
Alzheimer’s disease
T
2D-BioPAD will leverage the
NEW HORIZONS
HE PROJECT 2D-BioPAD aims to introduce a rich physical and chemical 2D-BioPAD kicked-off its activities in October 2023, and since
fast and cost-effective, non-invasive, reliable, properties of graphene, as well as the then has successfully implemented key elements to establish
digitally and graphene-enabled point-of-care a strong and coherent presence. The project designed a well-
(PoC) in-vitro diagnostics (IVD) system for expertise of the consortium partners defined graphic identity that extends across various promotion-
supporting the early diagnosis and progression to develop hand-held sensors for al materials (i.e., leaflet, poster, banner). The online sphere is
monitoring of Alzheimer’s Disease directly at also effectively covered with the creation of a website and
primary healthcare settings.
Alzheimer disease and validate them
active social media accounts on platforms such as LinkedIn,
in a clinical setting from patients’ Facebook and X (formerly Twitter), whereas a YouTube channel
blood samples.” will be launched in March 2024 along with the project’s
MEETING NEW CHALLENGES promotional video.
2D-BioPAD leverages the unique properties of
Alzheimer’s disease (AD) is the most prevalent form of
Aristeidis Bakandritsos graphene and its derivatives to deliver a graphene-
dementia,1 affecting more than one in nine people aged 65 and From a scientific perspective, 2D-BioPAD has geared up with based point-of-care diagnostics system.
Project Coordinator
older. The disease is one of the most severe factors driving
GR APHENE F L AGSHIP ANNUAL REPORT 2023
GATEPOST
and communities. GATEPOST also supports SDG 13, to combat
climate change and its effects. The GATEPOST technology
enables 56/6G applications of the future, which will reduce
greenhouse gas emissions and enable new climate mitigation
and adaptation measures.
Introducing the first Graphene-based
All-Optical Technology Platform for a
NEW HORIZONS
Secure Internet of Things and exciting In the first two years of the project, the focus will be on the
5G/6G applications conception and design of the system and devices. The
GATEPOST project team will achieve the first milestone in the
development and integration of the graphene process by the
end of 2024. The large-scale integration of graphene into
If we succeed in combining silicon nitride complementary metal-oxide semiconductors
T
graphene with standard (CMOS) has been challenging. Progress has been slow, mainly
due to a lack of infrastructure.
CMOS processes, we will be on the
ODAY, THE INTERNET of Things (IoT) is an verge of a breakthrough in data As the main challenge lies in the maturity of graphene process-
es within standard CMOS environments, the main objective of
integral part of our everyday lives and is no processing and memory.” GATEPOST is to fabricate and demonstrate a radically new
longer a dream of the future. Devices connect-
ed locally or over IoT not only make our daily graphene-based all-optical processing platform, integrated and
Mindaugas Lukosius
lives easier and more convenient, but also tested in a real CMOS pilot line. The unique expertise of each
Project Coordinator
more efficient. The same is true of 5G/6G consortium member in all-optical digital logic, neuromorphic
technologies, which will enable new applica- computing, memory and ultra-fast clock generation enables the
tions by transmitting data without delay. GATEPOST project team to tackle the challenges together.
Experts will be able to support medical interventions by Cybercrime continues to be one of the biggest challenges
GR APHENE F L AGSHIP ANNUAL REPORT 2023
2DNeuralVision
2DNeuralVision will contribute to Europe’s sustainability goals
by developing and implementing advanced technologies in
neural vision, leveraging two-dimensional materials (2DM).
This initiative likely enhances energy efficiency, reduces the
environmental impact through a reduction in the power
Developing a novel low-power consumption of 2DM pixels and the use of non-toxic colloidal
consumption vision system that materials, hence making the solutions environmentally friendly
and aligning with the European Green Deal and the Paris
could be used for adverse weather Agreement. By aligning with these goals, 2DNeuralVision helps
and low-light conditions Europe move towards a more sustainable and environmentally
conscious technological landscape.
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2DNeuralVision envisions the NEW HORIZONS
realisation of advanced imaging Over the next years, 2DNeuralVision will make progress in the
development of integrated photonic and electronic compo-
HE HORIZON EUROPE project 2DNeuralVision and vision systems that enable perception nents, including a 2DM-enhanced wide-spectrum image sensor
brings together seven European research
centres, leading universities, and innovative
for ADAS at scale, featuring low-cost and optical neural network (ONN). The project also expects to
provide significant advances in the development of wafer-scale
companies from four different countries to image sensors with extended spectral BEOL (black end-of-line) processes for graphene and transi-
develop the enabling components for a low-
power consumption, computer vision system
coverage and low-power consumption tion-metal dichalcogenide (TMDCs). Challenges in this process
optical neural networks. Such break- may include technical hurdles, resource constraints or unfore-
that could be used for adverse weather and
seen issues. Overcoming them could involve collaborative The 2DNeuralVision team.
low-light conditions. throughs will be enabled by the use problem-solving, securing additional resources and staying Credit: 2DNeuralVision
Funded with €5.5 million from the European Commission, this of 2D materials and quantum dots.” adaptable to evolving circumstances.
initiative seeks to develop the enabling photonic and electronic
Gerasimos Konstantanos Complementing the work development framework, 2DNeural-
integrated circuit components to achieve a novel computer
GR APHENE F L AGSHIP ANNUAL REPORT 2023
Next-2Digits
SUSTAINABLE SOLUTIONS
Next-2Digits introduces sustainable solutions
in alignment with the European Green Deal
and Europe fit for the digital age. The project
features a laser-based process for the selec-
Integrating graphene in photonic tive transfer of graphene/2DM, offering a
integrated circuits digital and solvent-free additive manufactur-
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ing process based on laser pulses. This
approach eliminates the use of chemicals,
minimises material waste and reduces
HE NEXT-2DIGITS’ integration of graphene and non-recurring engineering time. The single-
other 2D materials (2DM) into photonic inte- step transfer method, free-form processing
grated circuits (PICs) and optoelectronic and absence of masks contribute to a
Graphene empowers sustainable and efficient process, with
integrated circuits (OEICs) will overcome the
main challenges associated with performance, photonic integrated circuits minimal waste production.
compactness and cost-effectiveness of the with laser precision transfer.”
PIC- and OEIC-based devices. These sustainable practices offer significant
benefits, including the LDT method as a green
Ioanna Zergioti semiconductor processing example, replacing
Impurities and defects in circuits, especially when polymers Project Coordinator
and solvents are involved, drastically impact devices’ perfor- chemicals with laser light. The intrinsic
mance. Next-2Digits will introduce direct wafer-scale integra- cleanliness of the transfer method minimises
tion of graphene in PICs, a technique that enhances the unique undesired recombination processes and stray
Validation of Next-2Digits use cases: (1) LiDAR-based
properties of graphene when integrated into optical devices, doping that typically degrade device perfor- aerial mapping system; (2) waveguide-based NDIR gas
employing two innovative technologies: mance. As a result, PIC-based components sensor; (3) OCT imager.
developed through Next-2Digits exhibit up to
turing technologies developed within the project, thanks to the
i. Semi-dry transfer of graphene layers for full wafer-scale six times lower power consumption, signifi-
remarkable expertise of its consortium, Next-2Digits will pave
integration and direct die processing, and cantly reduced size and over 50% cost
the way for large-scale graphene production for photonic
GR APHENE F L AGSHIP ANNUAL REPORT 2023
Exploring the
Marvels of
2D Materials
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Properties and applications of TMDCs,
MXenes, h-BN and h-AlN
GR APHENE F L AGSHIP ANNUAL REPORT 2023
GIANCE Composites
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PARTNERS
Fundació EURECAT, Spain
HE GIANCE project is a pioneering initiative
Centro Ricerche FIAT SCPA, Italy
aimed at revolutionising the landscape of
Boeing Turkey Aviation and Trade Ltd. Co., Turkey
graphene and other 2D materials (2DM) by The project GIANCE is revo- Idryma Technologias Kai Erevnas, Greece
establishing a holistic, integrated and indus-
lutionising the graphene and Consiglio Nazionale delle Ricerche, Italy
try-driven platform. Our mission is clear: to
Faurecia Systemes d’échappement SAS, France
design, develop and scale-up the next gene- related 2D materials landscape, driving Fraunhofer Gesellschaft zur Foerderung der
ration of cost-effective, sustainable and high-
performance 2DM-based multifunctional sustainable solutions and impactful Angewandten Forschung EV, Germany
Dawn Aerospace Nederland B.V., Netherlands
composites, coatings, foams and membranes, all with a innovations across various sectors, University of Northumbria at Newcastle, UK
keen focus on real-world applications and sustainability.
including automotive, aerospace, energy Fundacion Bcmaterials – Basque Centre for
Materials, Applications and Nanostructures, Spain
(hydrogen economy) and water treatment. IRIS SRL, Italy
MEETING NEW CHALLENGES
With our collaborative efforts, we’re Graphene hexagonal lattice
Crossfire Srl, Italy
Our project addresses a myriad of challenges faced by Stichting Koninklijk Nederlands Lucht –
industries worldwide. By engineering advanced materials with shaping a greener, more sustainable structure, 3D model.
en Ruimtevaartcentrum, Netherlands
enhanced thermal, mechanical and chemical attributes, we future for industries worldwide.” Fundacion Para La Promocion De La Innovacion,
aim to provide functionalities ranging from wear resistance to
GR APHENE F L AGSHIP ANNUAL REPORT 2023
2D-PRINTABLE
not printable. In the paradigm proposed by 2D-PRINTABLE,
silicon-based TFTs can be replaced with printed nanosheet-
based TFTs, to reduce both the cost and energy consumption
of mobile devices, thereby ushering in a new era of sustainable
and cost-effective electronic displays.
Developing new 2D materials and
heterostructures for printed digital In summary, 2D-PRINTABLE aims to accelerate the outputs of
the Graphene Flagship to develop new materials and process-
devices using sustainable liquid ing technologies allowing the production of high-performance
exfoliation and deposition printed electronic devices, reinforcing European leadership
within the printed electronics industry.
methods.
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2D-PRINTABLE will be pivotal SUSTAINABLE SOLUTIONS
in allowing us to use liquid The 2D-PRINTABLE project contributes to Europe’s sustain-
ability goals by embracing environmentally friendly practices
HE WORLD OF MATERIALS SCIENCE and exfoliation methods to develop a palette throughout its entire supply chain. The newly developed
nanoscience has been revolutionised by 2D
materials (2DM).Thanks to their exceptional
of new 2D materials perfectly designed materials’ potential (nano)toxicity will be evaluated to guaran-
tee maximum safety in the entire supply chain. Such measures
physical and chemical properties they have for use in high performance printed will ultimately enable the development of greener, more
enabled ground-breaking applications in
various fields, such as optoelectronics, energy,
electronic applications.” sustainable, and circular materials and processes. A pivotal
aspect of the project’s commitment to sustainability is the
sensing technology and composite materials. Artistic visualization of two dimensional
Jonathan Coleman rigorous identification and application of green solutions. The
However, the key to unlocking their full heterostructures.
Project Coordinator shift toward greener synthesis methods adheres to Responsi-
technological potential lies in finding cost-effective methods
ble Research and Innovation and Safe and Sustainable by
to harness these properties on a larger scale, to transfer the
Design criteria, contributing to a more sustainable and
superlative electronic properties of individual nanosheets on
Through the 2D-PRINTABLE project, we will demonstrate that environmentally friendly supply chain. The project strongly
GR APHENE F L AGSHIP ANNUAL REPORT 2023
2D ENGINE
NEW HORIZONS
In the first year, 2D ENGINE will focus on the growth and
validation of 2D phases to make sure that the hexagonal 2D
phase is obtained, as targeted. Then, the consortium will
evaluate the stability of the materials in order to prepare for
Engineering new 2D materials the device fabrication planned within the first 36 months of the
phases not existing in nature project. To achieve our most urgent objectives in the first 18
months, the main challenges faced are associated with the
growth of ultrathin layers below the critical thickness to induce
the transition to the 2D hexagonal phase. An important, related
issue is to obtain large-area crystals in the mm scale, to
facilitate device fabrication. To face these challenges, two
different growth methodologies, namely liquid metal catalysis
This project is pushing the
I
and molecular beam epitaxy will be employed to maximise
boundaries of engineering by our chances of success. An equally important challenge is to
confirm the 2D hexagonal phase of the grown thin films. To
synthesising new 2D materials.” achieve this, several in situ and ex situ surface analytical
MAGINE MATERIALS as thin as a single atom, yet
possessing incredible strength, flexibility and electrical techniques will be employed, including high-resolution and
Thanasis Dimoulas high-sensitivity synchrotron X-ray scattering, complemented
properties. These are not the stuff of science fiction, Project Coordinator
but the result of cutting-edge engineering. Two-dimen- by atomistic modelling.
sional materials (2DM), best exemplified by graphene –
a single layer of carbon atoms arranged in a honeycomb
lattice – have opened the door to a universe of COLLABORATIONS
possibilities that were previously unimaginable. Collaboration with other projects in the electronics and
photonic clusters of the Graphene Flagship ecosystem is
In this project we are pushing the boundaries even further by investigated. The 2D ENGINE materials are 2D semiconductors expected to benefit 2D ENGINE, although these projects have The possibilities posed by 2D materials and their
engineering new phases of 2DM which cannot be produced in and insulators with sp2 hybridisation offering stability that higher technology readiness level (TRL). Interaction with the properties are not the stuff of science fiction, but
GR APHENE F L AGSHIP ANNUAL REPORT 2023
2DSPIN-TECH
Sustainable Materials: Spintronic devices often require less
material to manufacture compared to conventional semicon-
ductor devices. Additionally, the use of 2DM in spintronics
can further reduce the amount of material required, leading
to a smaller environmental footprint.
Applying spintronics to provide a break-
through for next generation computer
NEW HORIZONS
memory technologies The discovery of novel materials and nanoscience has been
a driving force behind the modern information technology (IT)
revolution. The rapid IT expansion generates a vast amount of
digital data that needs to be stored, processed and communi-
cated. However, traditional materials offer limited performance
The aim of the project and energy efficiency, hindering their ability to meet future
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is to demonstrate e computing demands. 2DSPIN-TECH envisions a new paradigm
in IT, one in which, novel atomically thin two-dimensional (2D)
fficient 2D spin-orbit torque quantum materials and their heterostructures are utilised. 2DM
HE FLOW OF charged electrons can generate memory devices.” will have a significant impact on IT due to their unique electron-
electrical current, and in addition to this charge ic properties. 2DSPIN-TECH has the ambition to exploit novel
it also carries a spin. In the same way tradition- Saroj Dash 2DM heterostructures to develop an experimental prototype
al electronics uses charge current to represent Project Coordinator non-volatile magnetic memory device based on a basic
information as zeros and ones, the spin current spin-orbit torque mechanism.
can be used to represent the same binary data
in spintronics. Such devices should have The main challenges are the fabrication of high quality 2D
quicker switching times and lower power heterostructure devices and their interface engineering for
consumption than conventional devices because spin can be utilisation in non-volatile memory applications, which can be
2DSPIN-TECH proposes new concepts for MRAMs and shows Researchers working in the cleanroom.
manipulated faster and at lower energy costs than charge can. faster, energy efficient and multi-functional. To achieve this,
that graphene and other 2D materials (2DM) can potentially
GR APHENE F L AGSHIP ANNUAL REPORT 2023
SAFARI
Safe and sustainable by design
graphene/MXenes hybrids
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energy storage, shielding of
electromagnetic field, water purification,
HE SAFARI PROJECT is developing a new kind
of super-thin material called MXenes in a way construction of sensors and biosensors
that’s safe for people and the environment. as well as lubrication and catalysis.”
MXenes are remarkable for their properties,
which can enhance products we use every day, Dariusz Garbiec
like electronics and energy devices. Project Coordinator
Empowering
By establishing robust
standards, stakeholders are
empowered with confidence in material
innovation
quality and performance, while societal
trust in the safety and reliability of
emerging technologies is bolstered.”
through
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A CONTEMPLATION ON NANOMATERIALS Jörg Radnik
Standardisation
VS 2D MATERIALS Dr. Jörg Radnik is Senior Scientist
A pertinent question arises regarding the classification of 2D at the Federal Institute for Material
materials within the broader realm of nanomaterials. Radnik Research and Testing, Berlin in the
acknowledges the prevailing classification but anticipates Division 6.1 “Surface analysis and
future deliberations on whether distinct standards for 2D Interfacial Chemistry” and working in
materials are warranted. As the field evolves, collaborative the competence centre nano@BAM.
discussions will be imperative to ensure a nuanced approach
to standardisation, one that fosters innovation while upholding
Illuminating the world of 2D materials regulatory rigor and safety standards.
Forging
ahead
The 2D-EPL’s technical leader Inge
Asselberghs reflects on the successes
of the project and future of 2DM
integration, and the close of the Horizon
2020 phase of the Graphene Flagship.
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that graphene and other
2D materials not only have different
EN YEARS HAVE now passed since the kick-
off of the Graphene Flagship with European unique characteristics, but also
researchers joining forces in developing 2D require dedicated handling in a
materials-based processes, material and
device models, devices and circuits exploration
fabrication environment.”
GR APHENE F L AGSHIP ANNUAL REPORT 2023
Gradually, process integration is moving in the direction of The 2D-EPL team is ready to jointly take the final steps for
down selecting the more industry-relevant processes with successful project completion, and move towards the next
the collection of relevant datasets on repeatability, uniformity phase of the pilot line.
and variability.
Essential in a phase one pilot line project is finding the balance Inge Asselberghs
between investing in process maturation and serving custom- 2D-EPL Technical Leader
ers. Today’s 2D-EPL customers have both university and Graphene Flagship Science
company backgrounds. The incentive to join the multi-project and Technology Officer
wafer (MPW) runs can be research enablement, benchmarking
purposes or first prototype testing. Therefore, different stage
MPW runs have been offered by AMO and VTT. Having been
successful, additional MPW offerings have been added for
photonics applications by IHP and sensors by Graphenea.
What is the Graphene Flagship?
Visit graphene-flagship.eu