AMS Winasis 2019 Al Munawirx
AMS Winasis 2019 Al Munawirx
AMS Winasis 2019 Al Munawirx
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The Journal of Agromedicine and Medical Sciences (AMS) is a four-month periodical journal
(February, June and October) containing various articles in the form of research, systematic reviews
and case reports in the field of medicine focusing on:
1. Basic Medical Sciences
2. Clinical Medicine
3. Agromedical
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EDITORIAL TEAM
Editor in Chief
Dr. dr. Yunita Armiyanti, M.Kes
School of Medicine, University of Jember, Indonesia
Editorial Board
dr. Dwita Aryadina Rachmawati, M.Kes
School of Medicine, University of Jember, Indonesia
dr. Ika Rahmawati Sutejo, M.Biotech
School of Medicine, University of Jember, Indonesia
dr. Desie Dwi Wisudanti, M. Biomed
School of Medicine, University of Jember, Indonesia
dr. Dini Agustina, M.Biomed
School of Medicine, University of Jember, Indonesia
Layout Editor
dr. Jauhar Firdaus, M.Biotek.
School of Medicine, University of Jember, Indonesia
Proofreading Editor
dr. Rosita Dewi, M.Biotek.
School of Medicine, University of Jember, Indonesia
dr. Elvia Rahmi Margi Putri
School of Medicine, University of Jember, Indonesia
Production Editor
dr. Zahrah Febianti, M.Biomed
School of Medicine, University of Jember, Indonesia
Administrator
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6/15/2020 EDITORIAL TEAM | JOURNAL AMS
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6/15/2020 Vol 5 No 2 (2019) | JOURNAL AMS
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The Journal of Agromedicine and Medical Sciences (AMS) is a four-month periodical journal (February,
June, and October) that contains various articles in the form of research, systematic reviews and case
report in the field of medicine with a focus on basic medical sciences, clinical medicine, and agromedics.
All manuscripts submitted must contain original research that was not previously published and is not
being considered for publication elsewhere. All authors have read and agreed to the contents of the
manuscript, and that every experimental study reported in the manuscript has been carried out with the
approval of the ethics committee.
Author Index :
Ivan Iqbal Baidowi 61; Regina Finka 69; Ika Aulia Kurniasari 77; Afifatun Hasanah 84; Sarwendah Siswi
Winasis 90; Puput Sagita Mey Sandra 95; Dasarina Rizqi Amalia 101; Ekvan Danang Setya Pramudito 106;
Firman Herdiana 112; Yesi Warisman 118
https://jurnal.unej.ac.id/index.php/JAMS/issue/view/780 1/6
6/15/2020 Vol 5 No 2 (2019) | JOURNAL AMS
PUBLISHED: 2019-06-29
ARTICLES
The Correlation Between The Use of Personal Protective Equipment (PPE) and Soil-
Transmitted Helminths Infection in the Workers of Kaliputih Plantation Jember Regency
Ivan Iqbal Baidowi, Yunita Armiyanti, Zahrah Febianti, Yudha Nurdian, Bagus Hermansyah
61-68
The Role of Pili Protein 38,6 kDa Klebsiella pneumoniae as a Hemagglutinin and Adhesin
Protein which Serves as a Virulence Factor
Regina Finka, Dini Agustina, Dwita Aryadina Rachmawati, Enny Suswati, Diana Chusna Mufida, Ali
Shodikin
69-76
The Larvacidal Activity of Ethanol Extracts of Phyllanthus acidus Leaves on The Culex
quinquefasciatus Instar III/IV Larvae
Afifatun Hasanah, Bagus Hermansyah, Cholis Abrori
84-89
Potential of Cocoa Ethanol Extract Toward Nematocyst Tubul Firing Inhibition of Physalia
Utriculus Toxin In Vitro
Sarwendah Siswi Winasis, Al Munawir, Adelia Handoko
90-94
https://jurnal.unej.ac.id/index.php/JAMS/issue/view/780 2/6
6/15/2020 Vol 5 No 2 (2019) | JOURNAL AMS
Antioxidant Effect of Kenitu leaf Etanol Extract (Chrysophyllum Cainito L.) on Wistar Rat
Induced Cyclophosphamid
Ekvan Danang Setya Pramudito, Erfan Efendi, Muhammad Ali Shodikin
106-111
Diazinon Toxicity to Kidney and Liver of Wistar Male Rats in terms of Biochemical and
Histopathological Parameters
Desie Dwi Wisudanti, Firman Herdiana, Tegar Syaiful Qodar
112-117
The Effect of Belimbing Wuluh (Averrhoa Bilimbi L.) and Red Guava (Psidium Guajava L.)
Extract on Fasting Blood Glucose Levels of Diabetic Wistar Rats Model
Yesi Warisman, Arinda Lironika Suryana, Zora Olivia
118-123
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CURRENT ISSUE
https://jurnal.unej.ac.id/index.php/JAMS/issue/view/780 6/6
Potensi Ekstrak Etanol Biji Kakao Terhadap Penghambatan Firing Tubul Nematosista Racun
Physalia Utriculus Secara In Vitro
Potential of Cocoa Ethanol Extract Toward Nematocyst Tubul Firing Inhibition of Physalia
Utriculus Toxin In Vitro
1 2 3
Sarwendah Siswi Winasis , Al Munawir , Adelia Handoko
1
Mahasiswa, Fakultas Kedokteran, Universitas Jember
2
Departemen Patologi Anatomi dan Biomolekuler, Fakultas Kedokteran, Universitas Jember
3
Departemen Fisiologi, Fakultas Kedokteran, Universitas Jember
e-mail korespondensi: almunawir.fk@unej.ac.id
Abstrak
Diperkirakan 150 juta kasus envenomasi akibat sengatan ubur-ubur terjadi setiap tahun secara global. Terdapat
100 dari 10.000 spesies ubur-ubur di dunia diketahui berbahaya bagi manusia yang salah satunya adalah Physalia
utriculus. Tujuan penelitian ini ialah mengetahui potensi ekstrak etanol biji kakao (Theobroma cacao L.) terhadap
penghambatan firing tubul nematosista racun ubur-ubur (P. utriculus) secara in vitro. Metode yang digunakan
ialah true experimental design dengan post test only control group design. Penelitian terdiri atas 8 kelompok: 1
kontrol normal, 1 kontrol positif, 1 kontrol negatif, dan 5 perlakuan dengan pemberian ekstrak etanol biji kakao
berkonsentrasi 20%, 2%, 0,2%, 0,02%, 0,002%. Pengamatan dilakukan dengan menghitung persentase jumlah
nematosista yang mengalami firing. Hasil penelitian didapatkan rata-rata persentase firing pada kelompok kontrol
normal sebesar 42,50 ± 3,18, kelompok kontrol positif sebesar 37,97 ± 5,57, kelompok kontrol negatif sebesar
52,44 ± 2,98, dan kelompok perlakuan dengan pemberian ekstrak etanol biji kakao 20%, 2%, 0,2%, 0,02%, 0,002%
berturut-turut, yaitu 48,24 ± 5,37; 40,62 ± 7,10; 29,45 ± 5,39; 37,60 ± 9,78; 41,11 ± 3,92. Hasil uji statistik One Way
Annova menujukkan nilai signifikansi 0,001 (p≤0,05). Kesimpulan dari penelitian ini ialah ekstrak etanol biji kakao
dengan konsentrasi 0,2% paling berpotensi menghambat firing tubul nematosista racun ubur-ubur (P. utriculus)
secara in vitro.
Kata kunci: Physalia utriculus, kakao, racun, ubur-ubur
Abstract
There was estimated 150 million envenomation cases due to jellyfish stings occur globally every year. 100 from
10,000 jellyfish species in the world known to be dangerous, one them is Physalia utriculus. The aim of this study
was to determine the potential of cocoa (Theobroma cacao L.) ethanol extract toward nematocyst tubul firing
inhibition of jellyfish (Physalia utriculus) toxin in vitro. The method was true experimental design with post test only
control group design. The study divided into 8 groups: 1 normal control, 1 positive control, 1 negative control, and 5
treatments grups by giving cocoa ethanol extract with concentration 20%, 2%, 0.2%, 0.02%, 0.002%. The
observation was made by calculating the percentage number of firing nematocysts. The result showed average
percentage of firing nematocyst in the normal control group was 42.50 ± 3.18, positive control group was 37.97 ±
5.57, negative control group was 52.44 ± 2.98, and treatment group which given with cocoa ethanol extract 20%,
2%, 0.2%, 0.02%, 0.002% were 48.24 ± 5.37; 40.62 ± 7.10; 29.45 ± 5.39; 37.60 ± 9.78; 41.11 ± 3.92, respectively.
The One Way Annova statistical results test show significance value 0.001 (p≤0.05). The conclusion of this study
was the cocoa ethanol extract with concentration 0.2% has most potential to inhibit the jellyfish (P. utriculus)
nematocyst tubule firing in vitro.
Keywords: Physalia utriculus, cocoa, toxin, jellyfish
(a) dan (b) adalah nematosista intak sedangkan (c) dan (d)
Pembahasan
adalah nematosista yang mengalami firing tubul.
Asam asetat 5% atau cuka telah digunakan sebagai
standar pertolongan pertama pada kasus sengatan
Gambar 1. Macam-macam penampakan nematosista ubur-ubur selama kurun waktu 40 tahun (Yanagihara
intak dan nematosista yang mengalami firing et al., 2016). Hasil penelitian menunjukan bahwa
tubul
asam asetat 5% maupun ekstrak kakao memiliki
pengaruh yang signifikan terhadap penghambatan
firing tubul nematosista racun ubur-ubur (Physalia
Uji normalitas dan uji homogenitas menunjukkan
utriculus) secara in vitro. Berdasar hasil analisis
nilai signifikan (p>0,05) yang menunjukkan bahwa
statistik kelompok P3 (kakao 0,2%) memiliki nilai
data penelitian terdistribusi normal dan memiliki
rata-rata firing tubul nematosista lebih rendah dari
varian sama. Uji One Way ANOVA menunjukkan nila
pada kelompok kontrol positif (asam asetat 5%).
signifikan 0,001 (p<0,05) yang berarti bahwa
terdapat perbedaan jumlah firing tubul nematosista