Revision 2mar24
Revision 2mar24
Revision 2mar24
Dr/Ahmed Gad
www.newpetc.com
1
2- Which of the following statements is NOT something you would say to a patient who is prescribed
fluconazole 150 mg for vaginal thrush?
a) You should take this medicine exactly as directed by your doctor, usually in a single dose.
b) You should avoid alcohol and grapefruit juice while taking this medicine, as they may increase the
risk of side effects.
c) You should use effective birth control while taking this medicine and for at least one week after your
last dose, as it may harm an unborn baby.
d) You should see your doctor again if your symptoms do not improve or worsen after treatment, as
you may need different medicine or further tests.
4- What is the recommended dose of doxycycline for the prevention of malaria in adults?
a) 50 mg once a day
b) 100 mg once a day
c) 200 mg once a day
d) 400 mg once a day
5- Which of the following eye drops is not typically used for the treatment of allergies?
a) Ketotifen
b) Azelastine
c) Dexamethasone
d) Timolol
6- What is the usual dose of finasteride for the treatment of male pattern hair loss (androgenetic
alopecia)?
a) 1 mg per day
b) 5 mg per day
c) 10 mg per day
d) 0.5 mg per day
7- A patient has been taking digoxin for a heart condition for several years without any issues.
Suddenly, the patient starts showing symptoms of toxicity. What is the most likely reason?
a) The patient has developed an allergy to digoxin.
b) The patient has been exposed to plants or animals that contain similar substances to digoxin.
c) The patient has low potassium, low magnesium, or high calcium levels in the blood.
d) The patient has taken an overdose of digoxin.
8- Buprenorphine is often combined with which drug for the treatment of opioid use disorder?
a) Naloxone
b) Naltrexone
c) Methadone
d) Diazepam
10- Which medication can be used in the treatment of psoriatic arthritis, especially to help manage
joint inflammation and skin symptoms?
a) Prednisone
b) Mefloquine
c) Hydroxychloroquine
d) Allopurinol
11- A drug has a hepatic excretion rate of 70% and is absorbed by 60%. What is the bioavailability of
the drug?
a) 84%
b) 42%
c) 28%
d) 18%
12- What can happen when ciprofloxacin is given together with theophylline?
a) Theophylline levels in the blood may increase, leading to potential toxicity.
b) Theophylline levels in the blood may decrease, reducing its effectiveness.
c) Ciprofloxacin may cause an allergic reaction when taken with theophylline.
d) The combination can result in a higher risk of gastrointestinal side effects.
14- What is the drug of choice for the treatment of clonic seizures?
a) Phenytoin
b) Carbamazepine
c) Valproic acid
d) Benzodiazepines
15- What is the bioavailability of drug that has hepatic excretion of 0.6 ml & 40 % absorption:
a) 1.8%
b) 24%
c) 16%
d) 20%
16- We need to prepare 600 ml of 30% conc. And we have 50% stock solution, how many ml of stock
solution you need?
a) 1000 ml
b) 360 ml
c) 2.5 ml
d) 0.5 L
18- Plasma conc. is 4 mg/L & safe level is 1mg/L, for a drug have t½ = 1.6 days, for how many days
the drug should be stopped to reach the safe level?
a) 2 days
b) 3.2 days
c) 4 days
d) 1 day
20- Which antibiotic is least commonly used in the treatment of community-acquired pneumonia
(CAP)?
a) Amoxicillin
b) Azithromycin
c) Cefuroxime
d) Minocycline
21- What is the primary interaction between ketoconazole and rifampin when co-administered?
a) Increased risk of gastrointestinal side effects.
b) Enhanced antifungal activity of ketoconazole.
c) Increased plasma levels of ketoconazole.
d) Decreased plasma levels of ketoconazole.
22- Which of the following factors is least likely to be involved in the oral absorption of a drug?
a) Half-life (t1/2)
b) Weight of the drug molecule
c) Solubility in the gastrointestinal (GI) tract
d) First-pass metabolism
24- how much of the 100% injection of a drug is required to make 100 ml of admixture containing
7.5 mg in 2.5 ml?
a) 0.3 ml
b) 0.4ml
c) 0.5ml
d) 0.6ml
25- The composition of 2g suppositories is 1.8% Balsam Peru. How many milligrams (mg) of Balsam
Peru is required to prepare 12 suppositories?
a) 200 mg
b) 216 mg
c) 360 mg
d) 432 mg
27- Calculate the Css if VD=3L t½= 2.5 hrs and the rate of infusion is 100 mg/hr.
a) 360 mg/L
b) 240 mg/L
c) 120 mg/L
d) 60 mg/L
28- When counseling a patient about using Fentanyl patches, which of the following statements is
correct?
a) Fentanyl patches should be applied to broken or irritated skin to ensure better absorption.
b) The patch should be changed every 72 hours to maintain a constant level of pain relief.
c) Fentanyl patches can be cut into smaller pieces if the prescribed dose is too strong.
d) Fentanyl patches can be disposed of in regular household trash.
29- A patient has been taking ibuprofen for 7 days before visiting the dentist, and the dentist
prescribes ibuprofen for tooth pain. What is your recommendation?
a) Continue the prescribed ibuprofen as directed by the dentist.
b) Stop taking ibuprofen immediately and inform the dentist about prior usage.
c) Take paracetamol instead of ibuprofen for tooth pain.
d) Consult a physician before taking any medication.
31- Which of the following is a potential interaction between benzodiazepines (BZDs) and
simvastatin?
a) Increased sedation and drowsiness
b) Elevated blood pressure
c) Enhanced cholesterol-lowering effect
d) Increased risk of gastrointestinal bleeding
33- A patient is taking a statin (cholesterol-lowering medication), an ACE inhibitor (blood pressure
medication), and has developed the flu. What should be given in this situation?
a) Amoxicillin
b) Oseltamivir
c) Paracetamol
d) Loratadine
34- Which of the following statements accurately describes the relationship between an agonist and
an antagonist regarding their affinity for a receptor?
a) An agonist has higher affinity for the receptor compared to an antagonist.
b) An antagonist has higher affinity for the receptor compared to an agonist.
c) Both agonist and antagonist have equal affinity for the receptor.
d) The affinity of an agonist or antagonist for the receptor is not relevant to their activity.
35- What is the significance of the interaction between ethinyl estradiol and hypericum (St. John's
wort)?
a) Hypericum decreases the efficacy of ethinyl estradiol, leading to a higher risk of pregnancy.
b) Hypericum increases the efficacy of ethinyl estradiol, improving contraceptive effectiveness.
c) Hypericum has no significant interaction with ethinyl estradiol.
d) Hypericum enhances the absorption of ethinyl estradiol, leading to increased blood levels.
36- What is the primary concern regarding the interaction between gemfibrozil and statins?
a) Increased risk of gastrointestinal side effects
b) Reduced effectiveness of statins in lowering cholesterol levels
c) Risk of rhabdomyolysis and myopathy
d) Elevated blood pressure
37- Which of the following statements is true regarding the interaction between grapefruit juice and
rosuvastatin?
a) Grapefruit juice increases the blood levels of rosuvastatin by inhibiting its metabolism.
b) Grapefruit juice decreases the effectiveness of rosuvastatin by inducing its metabolism.
c) Grapefruit juice does not interact with rosuvastatin to a significant extent.
d) Grapefruit juice enhances the side effects of rosuvastatin by increasing its absorption.
39- Which of the following is the most effective way to increase the absorption of a neutral drug
across a lipophilic membrane?
a) Increasing the temperature of the solution
b) Increasing the pH of the solution
c) Increasing the surface area of the drug particles
d) Increasing the concentration of the drug in the solution
42- Which of the following factors is NOT a significant contributor to the excretion of drugs in breast
milk?
a) Low maternal plasma concentration
b) Lipid solubility of the drug
c) Molecular weight of the drug
d) pka of the drug
43- When counseling a patient about transdermal patches, what advice should be given regarding
their application?
a) Apply patches directly over areas of intense heat.
b) Apply patches on hairy skin for better absorption.
c) Avoid exposing patches to direct heat sources.
d) Cut patches into smaller pieces for more controlled dosing.
44- What key event occurs during the early stages of HIV infection?
a) RNA to RNA
b) DNA to RNA
c) RNA to DNA
d) DNA to DNA
48- What is the % w/w of bicarbonate in a saturated solution prepared by dissolving 2 grams of
bicarbonate in 20 mL of water (density of water = 1 g/mL)?
a) 1%
b) 5%
c) 10%
d) 20%
49- What is the volume of castor oil is required to prepare 500g of zinc in castor oil solution with
conc. of 50%w/w solution (density of the solution 0.9g/ml)?
a) 100 ml
b) 278 ml
c) 250 ml
d) 1110 ml
50- 1 g penicillin every 6hour and given for 3 days. if 150 mg equivalent to 250,000 units then how
many units will be in total dose.?
a) 20 U
b) 200 U
c) 2 million U
d) 20 million U
53- What is the typical loading dose of Amiodarone used in the treatment of arrhythmias?
a) 100 mg
b) 200 mg
c) 400 mg
d) 600 mg
54- Which opioid is known for its exceptionally long duration of action?
a) Morphine
b) Fentanyl
c) Methadone
d) Hydromorphone
55- What term is used to describe the decrease of radioactivity to 50% of its initial value?
a) Radioactive Decay
b) Half-Life
c) Exponential Decay
d) Isotopic Stability
63- All can be happened in the interaction between Rifampin & warfarin except:
a) Pour anticoagulant effect.
b) ↓ INR
c) High bleeding tendency
d) ↓ Effect of warfarin
64- If the patient Has epilepsy and Mythenia gravies, what is the anticonvulsant that can be used?
a) Carbamazepine
b) Valproic acid
c) Lacosamide
d) Lamotrigine
68- A prescription of Methotrexate with the dose of 2.5 mg/kg once every two weeks, how many
tablets are required for 20 kg patient for the next 6 months:(1 tablet = 2.5mg)
a) 520 tabs
b) 240 tabs
c) 260 tabs
d) 120 tabs
69- If the conc. of a drug in the blood is 20mg after 2hrs of administration, and after 20 hrs become
2.5mg, calculate t½:
a) 3hrs.
b) 6hrs.
c) 8hrs.
d) 10hrs.
70- We need to prepare 1L of 0.067M NaCl, and 0.9% NaCl is available, what will we do? (Na= 23,
Cl= 35.5)
a) Dilute it with 0.56 L of water.
b) Dilute it with 0.77 L of water.
c) Dilute it with 1L of water.
d) Use without dilution.
72- Drug infusion rate is 2mg/kg/hr., infused for 12 hours, for 70kg patient. what is total dose?
a) 24mg
b) 140mg
c) 1680mg
d) 840mg
73- How many grams of water are used to prepare 60 g of potassium acetate solution have
concentration 5% w/w:
a) 300 gm
b) 57 gm
c) 3 gm
d) 5.7 gm
75- You have 500 ml of a steroid solution containing 200mg of dopamine HCL. You need to infuse
this solution at an appropriate rate (ml/minute) to deliver a dose of 5 mcg/kg/min for 70.5 kg
patient. what is the flow rate?
a) 0.1ml/min
b) 0.88 ml/min
c) 0.98 ml/min
d) 8.9 ml/min
77- If 500 ml of 15%w/v methyl salicylate is diluted to 1750 ml, what is the final conc.:
a) 4.29%w/v
b) 2.14%w/v
c) 6.34%w/v
d) 8.57%w/v
78- Which one of the following antihypertensives cannot be used for a patient having hypertension +
depression?
a) Enalapril
b) Atenolol
c) Verapamil
d) Methyldopa
80- Which of the following statements is true about vancomycin in skin infections?
a) Vancomycin is the drug of choice for all skin infections caused by (MRSA).
b) Vancomycin is less effective than antistaphylococcal beta-lactams for methicillin-susceptible S.
aureus infections.
c) Vancomycin is well absorbed from the gastrointestinal tract and does not require parenteral
administration.
d) Vancomycin has no risk of serious skin reactions and can be continued even if signs or symptoms
such as a rash or peeling occur.
88- Which of the following statements is correct when counselling a patient who is prescribed
chloramphenicol eye drops for bacterial conjunctivitis?
a) The patient should use the eye drops every two hours initially, then reduce the frequency as the
infection improves.
b) The patient should stop using the eye drops as soon as the symptoms disappear.
c) The patient should avoid wearing contact lenses while using the eye drops.
d) The patient should discard the eye drops after 14 days of opening.
91- What is the concentration of chlorhexidine in the eye drops used to treat Acanthamoeba
keratitis?
a) 0.01%
b) 0.02%
c) 0.05%
d) 0.1%
93- All the following are an appropriate counseling tip for administration of otic drops except
a) "Warm the solution before administration to improve effectiveness. “
b) "Tilt your head backward while administering the drops. “
c) "Shake the bottle vigorously before each use. “
d) "Administer the drops immediately after swimming."
94- How many ml of 1:60 stock solution of Ephedrine sulphate would be needed to make 30 ml of a
product with conc. 0.25%w/v:
a) 2.5ml
b) 3.5ml
c) 4ml
d) 4.5ml
95- A pharmacist is required to produce a litter of sodium chloride solution of 4.5% w/v, the only
available sodium chloride is in the form of tablets each containing 2.25 g and NaCl. the
number of tablets required is:
a) 45 tabs
b) 20 tabs
c) 9 tabs
d) 2 tabs
96- How much Ichthammol would be required to added to a 6%w/w Ichthammol in WSP ointment to
prepare 500 g of a 20% w/w Ichthammol in WSP?
a) 14gm
b) 64.5gm
c) 74.5gm
d) 84.5gm
97- What is the amount of Magnesium chloride (MgCl2.6H2O; MW =203.3) required to prepare 100
ml of solution such that 10 ml diluted to 1 litre yields a solution containing 0.30 mEq of
Mgᶧ²/ml?
a) 305 g
b) 305 mg
c) 30.5 mg
d) 610 mg
99- The pka value for Acetic Acid is 4.8. A buffer solution containing 0.1 mol/L Acetic Acid and 0.2
mol/L Sodium acetate would have a pH of:
a) 4.8
b) 4.9
c) 5.1
d) 5.8
100- A solution of an antibiotic compound was found to lose 50% of its potency within 5.5 days
when stored in the refrigerator, assuming first order the degradation what is the shelf life
under these conditions?
a) 7 hrs
b) 12 hrs
c) 13.7 hrs
d) 20 hrs
101- A doctor orders a 2g vial of Amoxicillin Sodium to be added to 500L of intravenous fluid. The
intravenous administration rate is 125ml/hour. Assuming a uniform rate of flow, how much
Amoxicillin Sodium will the patient receive per minute?
a) 833 mg
b) 83.3 mg
c) 8.33 mg
d) 300 mg
102- If Digoxin has a half-life of 35 hrs how long will it take for a toxic plasma concentration of 8
ng/mL to decline to a therapeutic plasma concentration of 2 ng/mL?
a) 17.5 hrs
b) 35 hrs
c) 70 hrs
d) 105 hrs
107- All the following treatments for personal articles infested with head lice would be effective
except:
a) Placing woolen hats in a plastic bag for 2 weeks.
b) using an aerosol of pyrethrins with piperonyl butoxide sprayed in the air of all bathrooms.
c) machine-washing clothes in hot water and drying them using the hot setting on the dryer.
d) dry-cleaning woolen scarves.
110- Which of the following is the correct method for the preparation of clindamycin cream in a
pharmacy lab?
a) Mix clindamycin with water, then add alcohol.
b) Mix clindamycin with propylene glycol, then add alcohol and water.
c) Mix clindamycin with alcohol, then add water.
d) Mix clindamycin with water first, then add alcohol and propylene glycol.
114- Vincristine has been commonly associated with which of the following adverse events?
a) Neurotoxicity
b) Gout
c) Duodenal ulcers
d) Blood clotting
115- All the following are examples of type I immediate or allergic hypersensitivity except:
a) Hay fever
b) Pollen allergy
c) Systemic lupus erythematosus
d) Allergic asthma
Answers
1 B 26 A 51 C 76 D 101 C
2 B 27 C 52 A 77 A 102 C
3 A 28 B 53 D 78 D 103 D
4 B 29 B 54 C 79 D 104 D
5 D 30 D 55 B 80 B 105 D
6 A 31 A 56 C 81 B 106 B
7 C 32 B 57 A 82 A 107 B
8 A 33 B 58 A 83 D 108 D
9 C 34 B 59 C 84 A 109 A
10 A 35 A 60 B 85 A 110 B
11 D 36 C 61 A 86 C 111 D
12 A 37 C 62 C 87 C 112 D
13 A 38 C 63 C 88 C 113 B
14 C 39 C 64 C 89 C 114 A
15 C 40 C 65 D 90 D 115 C
16 B 41 D 66 A 91 B 116 A
17 A 42 A 67 B 92 B 117 A
18 B 43 C 68 C 93 A 118 A
19 B 44 C 69 B 94 D 119 B
20 D 45 A 70 A 95 B 120 C
21 D 46 C 71 A 96 C 121 B
22 A 47 C 72 C 97 A
23 C 48 C 73 B 98 A
24 A 49 B 74 D 99 C
25 D 50 D 75 B 100 D