Immunization Notes
Immunization Notes
Immunization Notes
NATIONAL COORDINATORS
Dr Geeta Patil (Scientific Committee)
Dr Kottooru Srisailam
Dr Pawankalyan
Experts
Convenor
Dr S G Kasi
Members
Dr Sanjay Marathe
Dr Sunil Kumar Agarwalla
Dr Sanjeev Gupta
Dr Muralidhar Reddy
Vaccination is a process in which killed or modified disease causing germs, are introduced
into the body, commonly by injections, but also by oral route and nasal sprays. The available
vaccines prevent more than 20 diseases helping people of all ages live longer, healthier lives.
Vaccination is a simple, safe and effective way of protecting baby against harmful diseases,
before they come in contact with the germs. It uses the body’s natural defences to build
resistance to specific infections and makes immune system much stronger. Vaccines reduces
the risk of complications and mortality following subsequent exposure to an infectious agent.
In this way vaccinated person develops immunity against the specific disease causing germ.
Vaccines have changed our perception about infectious diseases. Infections, which were
considered as a curse for mankind, have reduced considerably, due to the effect of vaccines.
Smallpox has been eradicated, polio is present only in two countries on this planet, measles,
rubella, diphtheria, pertussis has declined considerably. It should be remembered that only a
handful of infections-measles, rubella, polio, can be eliminated from the face of this earth.
The vast majority can only be kept under control and this can be achieved only by the
continued use of vaccines even after the diseases are no longer widely seen in the community.
We now have vaccines to prevent more than 20 life-threatening diseases. Immunization
currently prevents 3.5-5 million deaths every year from diseases like diphtheria, tetanus,
pertussis, influenza and measles.
Immunizations are also one of the best health investments money can buy. Immunization
protects health of individuals, communities and economies from the devastating effects of
Vaccine-Preventable Disease threats. The Covid-19 pandemic was a classic example of the
devastation that an infectious disease can cause and how vaccines can hasten recovery of the
economies from its effects.
Presently, the National Immunization Program (NIP), of the government of India, provides
protection against 12 disease causing germs. In the future, vaccines against HPV and typhoid
are in pipeline.
In India, about 27 million children are born every year. The National Immunization Program
(NIP), which targets every newborn for vaccinations, constitutes the largest immunization
program in the world.
The Indian Academy of Paediatrics (IAP) recommends vaccines against mumps, typhoid,
hepatitis A, chicken pox and influenza. These diseases are not a major public health burden,
but are important for improving the quality of life. Protection against these illnesses reduces
school absenteeism, loss of working days to the parents, prevents rare complications caused by
these disease causing germs and in general improves the quality of life.
The baby has spent 9 months in the mother’s womb, protected from all germs and getting the
optimal nutrition. From the moment of birth, the newborn is exposed to a multitude of germs,
some of them are potentially dangerous. The baby may have some protection against some of
the germs, but almost no protection against some of the dangerous germs. Hence, the need for
vaccines to protect the baby.
Vaccines are the most valuable gift that can be given to a child, for a long healthy and
productive life.
The National Immunization Schedule (NIP) by the Govt. of India
The Indian Academy of Pediatrics (IAP) schedule
Vaccines are like superheroes for your child’s health. They train the immune system to fight
off the dangerous germs. It will not make your child sick, but will train the immune system
how to recognize and fight off the real germ if exposed to it in the future.
This greatly reduces the risk of becoming seriously ill or spreading a disease to others.
Vaccines can protect against one or multiple diseases. Sometimes, multiple vaccines may be
given at once to protect against several diseases.
Vaccines trick the immune system into believing that the actual disease causing germs have
entered the body. When a vaccine is introduced into the body, the immune system of the body
interacts with the germs present in the vaccine and produces proteins known as antibodies,
which act only against the germs in the vaccine. In addition, certain cells get programmed to
remember this exposure to the germs. When the germ enters the body again, these specialized
cells known as memory cells, get activated and produce very large quantities of antibodies.
These antibodies surround the germs and kill them, thus preventing these germs from causing
disease in the vaccinated person. It should be noted that vaccines protect the vaccinated
individual only against the germ present in the vaccine.
3. Inactivated toxins. Some diseases e.g. Tetanus and Diphtheria are caused by
chemicals released by the organism. These chemicals are called toxins. Inactivated
toxins are made into toxoid vaccines. Tetanus Toxoid and Diphtheria toxoids are some
examples.
4. Segments of the pathogen. The vaccine contains specific proteins or sugars found on
the surface of the organism. Hib vaccine and the Pneumococcal conjugate vaccines
are some examples.
5. Genetic material of the organism. mRNA and DNA vaccines have shot into
prominence during the Covid pandemic. Covid vaccines by Pfizer and Moderna are
examples of mRNA vaccines and ZyCoV-D is an example of a DNA vaccine.
How are vaccines developed and tested before being used in the
population?
Each and every vaccine undergoes rigorous testing, in different phases, during its
development phase. The various phases of vaccine development are:
1. Exploratory Phase: in this phase, scientists study to find out which part of the
organism can be used as a vaccine, and whether any modification are necessary to
make that vaccine recognisable by the immune system of humans.
2. Pre-Clinical Phase: In this phase, the vaccine candidate is tested in laboratory animals
to check for safety and the ability of the vaccine to stimulate the immune response.
This phase may last 1-2 years.
Any vaccine, which is not proven to be safe, will never be used in humans, especially
very young children. Even after the vaccine is introduced in the population, they are
continuously monitored for any side effects which were not detected in the phase of
clinical trials.
When any unusual side effects are noticed following any use of vaccine ,well
established protocols are in place, by international bodies viz WHO, to establish
whether any reported side effects occurring following the administration of a vaccine
is caused by the vaccine itself or is a coincidental side effect. This is called adverse
events following immunisations(AEFI) surveillance ,reporting and causality
assessment.
Although generally very safe, like any other medicine, vaccines can cause side effects.
However, most of these are very minor and are of very short duration. Examples of this
type of side effects include pain, swelling or mild fever. Severe allergic reactions
following vaccinations are extremely rare and occur in about 1-2 cases per million.
Claims that vaccines cause allergies, autism, brain damage or diabetes have been
carefully researched and disproved.
Generally, extra doses of most vaccines are safe. These campaigns are conducted to raise the
population immunity against the targeted germs and to halt the transmission of the germs in
the community. This will hasten eradication of the germ. These programs are not primarily
intended for individual protection. It is your duty to vaccinate your child during these
campaigns. Examples of campaign mode vaccines include the oral polio vaccine (OPV-Pulse
polio campaign)and the Measles, Rubella (MR)campaign. Child should receive the vaccines
administered in campaign mode even if they have received these vaccines as part of their
routine immunisation. It is necessary and safe.
Vaccines are not for children only – Adolescents and Adults too need them.
§ Adults are 100 times more likely than children to die of diseases that can be prevented
by vaccines
§ Childhood administered vaccine induced immunity can begin to fade over time. So,
adults and adolescents may need periodic boosters of some vaccines e.g. Td
§ Some adults were never vaccinated as children
§ Newer vaccines were not available when some adolescents and adults were children.
Such adolescents and adults should receive these newer vaccines
§ As we age, we become more susceptible to serious disease caused by common germs
(e.g., Flu, Pneumococcus). Effective and safe vaccines are available against these
germs
FAQs
Babies may get some temporary protection from antibodies transferred, during
pregnancy, from the mother’s blood to the newborn. This is only for diseases to which
mother is immune. Breastfeeding may also protect the baby temporarily from minor
infections. These antibodies do not last long, leaving the baby vulnerable to disease.
3. Why should my baby receive vaccines so early in life? Can I postpone it by a few
months?
In developing countries like India, infection occur very early in life. Hence, it is
essential to begin the process of vaccinations when the baby is just a few weeks of
age. The baby does not have natural immunity to most of these infections. These
infections can be devastating to the baby.
6. We give so many vaccines, in such a short period of time, to such a young baby!
Will the baby’s immune system be overloaded?
The human body has a fantastic capability to respond to innumerable antigens at the
same time. Hence, multiple vaccines cannot overload the baby’s immune system or
make the baby’s immune system weak.
7. I have heard that many vaccines contain mercury which can damage the brain. Is
it true?
The type of mercury used in vaccines is called Thiomersal. Mercury in very low doses
can prevent the growth of germs in the vaccine vial. This is particularly important
when multi dose vaccine vials are being used. Large studies, done by very important
and prestigious medical organisations, have very clearly demonstrated that there is no
link between the use of mercury in vaccines and brain damage or autism. Mercury in
vaccines is safe.
9. My brother’s child developed features of autism in the second year of life, after the
administration of the MMR vaccine. He firmly believes that MMR caused autism
and has advised me not to administer the vaccine to my toddler. What are the
facts about the link between MMR and autism?
A scientific paper was published in 1999 by a British physician who claimed to have
evidence that the MMR (measles, mumps and rubella) vaccine was linked to autism.
The potential link has been thoroughly explored; study after study has found no such
link, and The Lancet, which had originally published it, has formally retracted the
original 1998 study, as there were serious methodological flaws and conflicts of
interest. It is likely that this misconception persists because of the coincidence of
timing between early childhood vaccinations and the first appearance of symptoms of
autism. MMR does not cause Autism.
10. Why do some children develop the disease in spite of taking the vaccines?
All vaccines are not 100% effective. Vaccines work by eliciting an immune response
in the body of the vaccinated person. This capacity to mount an immune response
may not be sufficient in a few individuals in the population. The vaccines may not
protect them. On the other hand, most vaccines protect over 95% of the vaccinated
individuals. Non-responsiveness to a vaccine is more an exception rather than a rule.
11. Can you get a disease from the vaccine that’s supposed to prevent it?
Live, attenuated (or weakened) vaccines are theoretically capable of causing illness:
because they can still replicate (though not well), mutation is possible, which can lead
to a virulent form of the pathogen. This has been reported with the oral polio vaccine.
However, it is very rare.
13. What if my baby has a cold or fever, or is taking antibiotics? Can they still get
vaccinated?
Yes. Your child can still get vaccinated if they have a mild illness, a low-grade fever,
or when taking antibiotics. Your doctor is the most appropriate person to take this
decision.
14. Why should I vaccinate my child against a mild illness like chickenpox?
Even uncomplicated cases of chickenpox cause children to miss a week or more of
school, with a caregiver missing work to care for the sick child. The disease can
spread to other children. If a child with a weak immunity gets chickenpox, it can lead
to serious complications.
16. What are the common side effects observed after vaccination?
Vaccines, like any medication, may cause some side effects. Most of these side effects
are very minor, like soreness or some swelling where the shot was given, fussiness, or
a low-grade fever. These side effects typically only last a couple of days and are
treatable.
18. Why do the private providers (Indian Academy of Paediatrics schedule) offer
some vaccines that are not available in Government’s programme?
The government immunisation programme (NIP) caters to the population at large and
provides vaccines recommended by the National Technical Advisory Group on
Immunisations(NTAGN). It targets diseases which cause high mortality and
morbidity in the community and thus have a significant public health importance. On
the other hand, private providers follow the IAP schedule, which includes vaccines
which are not public health issues, but which are important at the individual level.
These vaccines prevent loss of school days, prevent loss of work days by the
caregivers and improve the quality of life. NIP provides fewer vaccines than the IAP
schedule. Moreover, the schedules of the NIP and IAP differ to some extent.
19. If all the children in my surrounding are vaccinated, should my child still receive
vaccines? Will my child not be protected by “Herd Immunity”?
A population with a high number of members with immunity to a particular disease or
pathogen may give protection from that infection to the small number who have not
been vaccinated. This is known as “herd immunity” or “community immunity” or
“population immunity”. However, it is not safe to depend on herd immunity for
individual protection. Herd immunity is applicable only for diseases where there is a
person-to-person transmission and the germ does not exist in any host apart from
humans.
20. My child missed the 3rd dose of the Hexavalent vaccine given at 14 weeks. He is
now 5 months of age. Should the doses be started all over again?
No. Delayed doses does not warrant restarting the entire series. Your child can receive
the 3rd dose now and complete the schedule. However, you should be timely in the
vaccinations and avoid such situations.
21. The government conducts nationwide programs e.g Pulse Polio and MR
campaigns. My child has received all his regular vaccines. Should he still receive
these additional doses?
Yes. These campaigns are conducted to raise the population immunity against the
targeted germs and to halt the transmission of the germs in the community. This will
hasten eradication of the germ. These programs are not primarily intended for
individual protection. It is your duty to vaccinate your child during these campaigns.
Additional doses of vaccines are safe.
Tag lines
1. Healthy Beginnings, Bright Futures: Routine Immunization is the way forward
2. Ensuring a Healthy Start: Routine Immunization for every child
3. Immunization for everyone : From New born to Old age
4. Make your child a VIP (Vaccinated, Immunized and Protected)
5. Immunizations: The best investment for a child's health My choices
Press note
"With the exception of safe water, no other public health intervention, not even
antibiotics, has had such a major effect on mortality reduction as have resulted from the
extensive use of vaccines."
Routine Immunization
is birth right of the child
Experts
Dr S G Kasi(Convenor)
Members
Dr Sanjay Marathe
Dr Sunil Kumar Agarwalla
Dr Sanjeev Gupta
Dr Muralidhar Reddy
,
Studies in animals
Why so many vaccines ? and
so early in life?
• Immunity transferred from mother and from breast milk does not
last for more than a few months.
• The baby is susceptible to many dangerous infections
• In a country like India, these disease occur very early in life as
compared to High-Income western countries
• So, the baby needs many vaccines in the first year of life.
Why so many doses of
the same vaccine?
Globally, How well
have vaccines worked?
How well have vaccines worked in
India?
DEBUNKED
Vaccines do so many GOOD things
to your baby ….
And Remember
Vaccines are not just for babies!!