Scribd Logo
Upload

Welcome to Scribd!

  • 8 views

    Uterus

    Uploaded by

    yaraabdulkaderali
    The document provides information about the structure and functions of the uterus, endometrial cycle, endometritis, endometriosis, adenomyosis, endometrial hyperplasia, benign and malignant tumors of the uterus. It describes the etiology, clinical features, gross and microscopic findings of these conditions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Uterus

    Uploaded by

    yaraabdulkaderali
    8 views8 pages
    The document provides information about the structure and functions of the uterus, endometrial cycle, endometritis, endometriosis, adenomyosis, endometrial hyperplasia, benign and malignant tumors of the uterus. It describes the etiology, clinical features, gross and microscopic findings of these conditions.

    Original Description:

    Patho of uterus notes

    Original Title

    4. Uterus

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document provides information about the structure and functions of the uterus, endometrial cycle, endometritis, endometriosis, adenomyosis, endometrial hyperplasia, benign and malignant tumors of the uterus. It describes the etiology, clinical features, gross and microscopic findings of these conditions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    8 views8 pages

    Uterus

    Uploaded by

    yaraabdulkaderali
    The document provides information about the structure and functions of the uterus, endometrial cycle, endometritis, endometriosis, adenomyosis, endometrial hyperplasia, benign and malignant tumors of the uterus. It describes the etiology, clinical features, gross and microscopic findings of these conditions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 8

    Uterus

    structure
    fundus

    7
    4 Body
    Imitrium
    cervix

    Endometrial cycle

    First 15days proliferationphase

    Estrogen Mitosis
    Eygg

    Day 14 ovulation
    Graffian follicle releases Ova

    Corpus luteum cyst secretes Progesterone


    If ten

    chsefet.it into
    After 10 days Menstruation Endometrium

    If No pregnancy
    hormone drop shedding bleeding
    Endometritis
    Acute
    Etiology After Labour Abortion if contaminated atmosphere
    Ascending infection
    Strept A staph C trachomatis N gonorrhea E coli

    Gross Enlarged soft

    Endometrial edema
    M's Early congestion
    Aggregates of Neutrophils
    pus cells

    Late Endometrial necrosis


    spread of Infiltrate to myometrium pusNeutro

    clinical
    afiii.nu iYtsioruiantfiginiidscharge local
    Pus

    Chronic
    Etiology PD intrauterine devices

    M.s Plasma cells in endometrium


    Endometriosis
    Seen underM.s

    glandsfstrom
    uterus
    outs.de
    Presence of endometrial
    ectopic endometrium
    functioning
    Responds to hormonal change cyclic changes

    in reproductive women
    age

    sites
    ovaries Pouch of douglas
    ovarian uterine ligaments serosa of bowel
    Urinary bladder peritoneal cavity

    clinical
    chronic pelvic pain rectal pain
    dysamenorrhea dyspareunia
    Constipation frequentbleeding fibrosis obstruction

    Abnormal uterine bleeding

    Infertility fibrosis Adhesion

    Gross
    Red brown serosalnodules
    Endometrioma chocolate hemolyzedblood cyst
    chronichaemorrhage haemosidrin Laiden MQ
    Necrotic tissue
    Adenomyosis

    Invagination of deep layers of endometrium


    Into Myometrium

    Postmenopausal

    clinical Menorrhagia severe menstrual bleeding


    Dysmenorrhea

    Gross Diffusely enlarged


    Endometrial hyperplasia Histological proliferation
    of endometrial glands
    35

    Etiology
    Excessive Estrogen relative to progesterone
    so estrogen unopposed
    Failure of ovulation
    Prolonged admistration of exogenous HRT contraceptives

    Est producing ovarian lesions


    eg polycystic ovary Granulosa Theca cell tumour
    Obesity
    adiposetissueconverts steroid Precursors estrogens

    Clinical Abnormal uterine bleeding

    M.S 2 types
    simple only increase in numberofglands
    without Atypia
    Endometrial intraepithelial
    End hyperplasia with Atypia neoplasia EIN

    Complex architecture c cytologicAtypla


    B arrangement nuclearfeatures

    Intact BM

    Risks Endometrial Adenocarcinoma Malignant Transformation

    Treatment hysterectomy
    Editions
    Progestin therapy
    Tumors

    Benign
    Leiomyoma fibroid Uterus

    From smooth muscle Myometrium

    30 50 of females in reproductive life

    Etiology Estrogen dependant

    Gross Well circumscribed


    Firm rubbery whitetan ntramffff
    subserosal
    submuco.us

    CS whorled Trabeculated
    Single Multiple

    M S
    Well circumscribed Pseudocapsule Titi L I
    Interlacing bundles of Sm ms fibers Dense collagen
    bland nuclei no criteria of Malignancy

    Clinical Uterine bleeding surfacearea of endometrium


    Bladder disorders compression
    Impaired fertility interrupts Implantation
    Spontaneous abortion narrow cavity Fetal malpresentation
    Postpartum haemorrhage

    can be completely
    Asymptomatic
    discovered accidentally
    Metastatic
    Malignant Epithelial
    Primary Mesenchymal

    _Epithelial Endometrial carcinoma Most common malignant


    postmenopausal females
    In
    clinical Abnormal uterine bleeding

    Etiology Estrogen
    earlymenarche Latemenopause
    Nulliparity ChronicAnovulation progesterone exposure

    Est producing ovariantumours ERT Tamoxifen


    EIN complex Atypicalneoplasia Transformation
    Genetic predisposition LyncheSyndrome
    colorectal endom ovariantumours

    Hypertension DM obesity

    Gross LocalisedPolypoid mass


    or
    Diffuse Irregular ulcerated necrotic

    MS 2 Types
    Endometrioid Adenocarcinoma Serous tumors
    PTEN mutation TP 53 mutation Etonstressor
    Resembles normalglands Small Tufts ofepith
    around vascular core
    with nuclear Atypia
    Complex architecture Papillae
    may show squamous differentiation More Aggressive

    Prognosis Invasion of Myometrium


    Spread Local Blood Lymphatic
    t Mesenchymal Tumours

    Leiomyosarcoma sm.ms

    Etiology de novo from myometrium


    not from Leiomyoma

    Age Post menopause

    Gross Enlarged soft HNC


    Solitary bulky fleshy mass
    Invades uterine wall

    MS intersecting sm.ms fiber bundles


    Nuclear Atypia
    Necrosis Not in Leiomyoma

    Mitosis

    Carcino sarcoma Malignantmixed


    mullerian Tumors

    Very Aggressive
    2 Components epithelial Glands
    Mesenchymal Sm.msfibers C T

    Endometrial stromal sarcoma

    You might also like