Study Material Ug2
Study Material Ug2
Study Material Ug2
Goal:
The broad goal of the teaching of undergraduate students in Physiology aims at providing
the student comprehensive knowledge of the normal functions of the organ systems of the
body to facilitate an understanding of the physiological basis of health and disease.
Objectives
A.Knowledge :
1. Explain the normal functioning of all the organ systems and their interactions for
well‐coordinated total body function;
2. Assess the relative contribution of each organ system to the maintenance of the milieu
interior;
3. Elucidate the physiological aspects of normal growth and development;
4. Describe the physiological response and adaptations to environmental stresses;
5. List the physiological principles underlying pathogenesis and treatment of disease
B. Skills At the end of the course the student shall be able to:
D. Integration:
At the end of the integrated teaching the student should acquire an integrated knowledge of
organ structure and function and the regulatory mechanisms.
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List of systems included in Physiology:
General Physiology
Hematology
Nerve‐Muscle Physiology
Gastro‐Intestinal Physiology
Cardiovascular physiology
Respiratory physiology
Renal Physiology
Endocrine Physiology
Reproductive Physiology
Neurophysiology (Central Nervous System and Special Senses)
Integrated Physiology
Syllabus
THEORY
Components of blood: formation, regulation and functions; plasma proteins – origin, types,
variations and functions; Hemoglobin‐ synthesis, variants, functions and its breakdown &
Jaundice; Blood indices; Anemia and its classification; Hemostasis: mechanism, regulation &
disorders Anticoagulants; Blood groups, blood banking and transfusion; Immunity: types,
mechanism & regulation; ESR; Lymph‐composition, circulation and functions
Neuron and neuroglia: structures, types, functions; Resting membrane potential; Action
potential in nerve, skeletal & smooth muscle; Nerve fibres: classification, functions &
properties; nerve injuries, degeneration and regeneration in peripheral nerve;
Neuromuscular junction: structure, transmission of impulses, neuro‐muscular blocking
agents, Myasthenia gravis; Muscle fibres: structure, types & functions; Muscle contraction;
molecular basis (skeletal, smooth), Isotonic Vs. Isometric, Energy sources and metabolism,
gradation of muscle activity; muscle dystrophy, Myopathies; Strength‐duration curve
Structure and functions of kidney & juxta glomerular apparatus, role of renin‐angiotensin
system ; Renal blood flow; Mechanism of urine formation, concentration and diluting
mechanism; Concept and significance of ‘clearance’ tests; Renal regulation of fluid and
electrolytes & acid‐base balance; Structure and innervation of urinary bladder, physiology of
micturition, cystometry, and its abnormalities; Artificial kidney(dialysis) and renal
transplantation; Renal Function Tests
Mechanism of action of steroid, protein and amine hormones; Synthesis, secretion, transport,
physiological actions, regulation and effect of altered (hypo and hyper) secretion of pituitary
gland, thyroid gland, parathyroid gland, adrenal gland, pancreas and hypothalamus;
Physiology of bone and calcium metabolism; Physiology of growth; Physiology of Thymus
& Pineal Gland; Hormone function tests ; Obesity & metabolic syndrome; Stress response
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Reproductive Physiology: (PY 9.1 ‐ 9.12) (10hrs)
Sex determination; sex differentiation and their abnormalities; Puberty: onset, progression,
stages; early and delayed puberty; Male reproductive system: functions of testis,
spermatogenesis and its regulation, Cryptorchidism ; Female reproductive system:
functions of ovary and its control, menstrual cycle: Hormonal, uterine and ovarian changes;
Tests for ovulation; Physiological effects of sex hormones; Contraceptive methods for male
and female; Effects of removal of gonads on physiological functions; Physiology of
pregnancy, fetoplacental unit, pregnancy tests, parturition & lactation; Semen analysis;
Causes and principles of management of infertility; Hormonal changes and their effects
during perimenopause and menopause; Psychological and psychiatric disturbances
associated with reproductive physiology.
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PRACTICAL
The following list of practical is minimum and essential. Additional exercises can be
included as and when feasible and required. All the practicals have been categorized as
ʹProcedures to be performed’ and ʹDemonstrationsʹ. The procedures are to be performed by
the students during practical classes to acquire skills. These would be included in the
practical during University examination. Those categorized as ‘Demonstrations’ are to be
shown to students during practical classes. Questions based on these would be given in the
form of data, charts, graphs, problems and case histories for interpretation by students
during university examination.
I. Procedures to be performed by the students:
a.Haematology:
1. RBC count
2. WBC Count
3. Differential Leucocyte Count
4. Estimation of haemoglobin
5. Blood grouping
6. Bleeding time
7. Clotting (Demonstration of fibrin thread)
8. Calculate RBC indices ‐ MCV, MCH, MCHC.
b.Procedures to be performed on human subjects:
1. Mosso’s ergography.
2. Recording of Blood Pressure, pulse rate at rest and effect of posture.
3. Effect of mild and moderate exercise on blood pressure, pulse rate and respiratory
rate.
4. Demonstrate Harvard step test and describe the impact on induced physiologic
parameters.
5. Record and interpret Lead II ECG. Given a normal ECG, determine cardiac axis.
6. Spirometry ‐ Lung volumes and capacities, MVV and Dyspnoeic Index, Timed vital
capacity.
7. Peak Expiratory Flow Rate
8. Demonstrate Basic Life Support in a simulated environment
9. Visual field by Perimetry
c.Clinical Examination:
1. Components of history taking and general physical examination
2. Examination of radial pulse
3. Examination of Cardiovascular system
4. Examination of Respiratory system
5. Examination of abdomen
6. Examination of Higher mental functions
7. Examination of Sensory system
8. Examination of Motor system including reflexes.
9. Examination of Cranial Nerves
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II. Demonstrations:
I. Haematology:
1. Erythrocyte sedimentation rate
2. Haematocrit
3. Reticulocyte count
4. Platelet count
5. Osmotic fragility
2. Record Arterial pulse tracing using finger plethysmography*
3. Stethography
4. Tests of cardiovascular autonomic functions*
SKILL CERTIFICATION:
The list of certifiable skills is given below. The general instructions, blank template, samples
of certification checklist suggested for skill certification are provided as Annexure ‐1.
Topics Number
required
to
certify
as per
MCI
PY5.12 Record blood pressure & pulse at rest and in different grades of 1each x 3
exercise and postures in a volunteer or simulated environment
PY6.9 Demonstrate the correct clinical examination of the respiratory system 1
in a normal volunteer or simulated environment
PY Demonstrate the correct clinical examination of the nervous system: 1 each
10.11 Higher functions, sensory system, motor system, reflexes, cranial (total 5)
nerves in a normal volunteer or simulated environment
PY Demonstrate (i) Testing of visual acuity, colour and field of vision and 1 each
10.20 (ii) hearing (iii) Testing for smell and (iv) taste sensation in volunteer / (total 4)
simulated environment
SUGGESTED AREAS FOR INTEGRATION:
As per the “Competency based Undergraduate Curriculum for the Indian Medical Graduate
Medical Council of India”
EARLY CLINICAL EXPOSURE:
Clinical visits: 12 hours (Suggested format for assessing participation in ECE
sessions is provided as Annexure‐2)
Suggested hospital visits: (can include more)
Anemia, Jaundice, Visit to blood bank, Computerized lung function tests, acid peptic
disease, endoscopy procedure, dialysis unit, hemiplegia, etc.
Basic science correlations: 18 hours
Discussion based on case vignettes, graphs, clinical videos, patient in classroom
setting, etc linked to various systems in physiology.
LOG BOOK:
Suggested Template of logbook is attached as annexure. The minimum elements that needs
to be included are mentioned in the template provided for logbook.
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TEACHING HOURS AND METHODS:
SCHEME OF EXAMINATION:
Internal assessment:
(kindly refer section II for general guidelines)
Scheme for calculation of Internal assessment marks:
Theory (maximum marks) Marks Practicals Marks
Theory written paper 30* Practical exam and viva‐ voce 30**
Formative assessment Formative assessment
(Part completion tests/ (system‐wise 10 Early clinical exposure + Skill 5
reviews) certification
Practical record 5
Total 40 40
Please note:
*Prior to submission to the University, the marks for each of the three internal
examination theory assessments must be calculated out of 30 marks, regardless of the
maximum marks.
**Prior to submission to the University, the marks for each of the three internal
examination practical assessments must be calculated out of 30 marks, regardless of
the maximum marks.
Only the final marks out of 40 needs to be submitted to the University, separately for
theory and practical for each internal assessment.
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At least 50% marks of the total marks combined in theory and practicals/clinical
assigned for internal assessment is to be obtained in a particular subject to be eligible
to appear for university examinations. A candidate who has not secured requisite
aggregate in the internal assessment may be permitted to appear for another internal
examination as a remedial measure. If he/she successfully completes the remediation
measures prescribed by the Institution / University as the case may be, only then
he/she is eligible to appear for University Examination.
Students must secure at least 50% marks of the total marks (combined in theory and
practical) assigned for internal assessment to be declared successful at the final
university examination of that subject.
The third internal examination is the preliminary examination to be conducted on
the lines of the university examination.
The students should be made aware of the results of internal assessment.
Internal assessment marks will reflect as a separate head of passing at the university
examination.
The internal examination marks for the 1st, 2nd and 3rd internal examinations shall
be submitted to the University on or before 15th December, 15th March and 15th
July respectively.
Level of participation in early clinical exposure must be assessed and contribute to
the practical component as shown in the table above.
A suggested format for assessing participation in ECE is shown in APPENDIX 2 in
section II.
The scheme for calculation of the internal examination marks is given the table
above.
A clear record of all components that add to the internal assessment marks needs to
be maintained by the institution and retained by them for at least 5 years after
completion of the examination. Institutions may be asked to provide these details by
the University as and when required.
The internal and formative assessments provide ideal opportunities for students and
teachers to identify learning gaps. Teachers should provide high quality feedback to
each student to enable them to bridge these learning gaps.
A suggested format for providing feedback is shown in APPENDIX 3 section II.
Formative assessments also enable the early identification of students who are
struggling to achieve the intended learning outcomes. Early and appropriate
targeted remediation must be planned for such students.
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UNIVERSITY EXAMINATIONS
TABLE SHOWING SCHEME FOR CALCULATION OF UNIVERSITY EXAMINATION MARKS
(Practical I to IV)
There shall be two theory papers of 100 marks each and duration of each paper will be of 3
hours.
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B. PRACTICAL: 80 Marks
There shall be four practical sessions, each carrying 20 marks. The distribution of content
and marks for the practical would be:
g.Hematology (RBC count / WBC count / making a peripheral smear + DLC on the provided
stained slide / BT + blood group / Hb + blood group): 15 marks
h.Clinical problems: 5 marks
Note: the ‘procedures to be performed’ for practical exam under different sections (I to IV)
mentioned above needs to be strictly adhered to. The experiments kept under clinical
examination should allow for an assessment of the marks allotted (and not be a very
small component of the experiment for eg. “elicit a knee jerk” is not a complete
experiment).
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Paper 1 (Max 100 marks)
General Physiology 05
Hematology 20
Cardiovascular Physiology 25
Respiratory Physiology 20
Gastrointestinal Physiology 15
Renal Physiology 15
Note: All the questions should be structured compulsorily. One short essay (5 marks) to
be preferably a case vignette.
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Annexure 1
General instructions
General information:
1. There are 13 skills that need to be certified in Physiology
2. These skills will be tested in normal, healthy volunteers or simulated environment
3. The focus will be on whether students perform the procedures correctly
4. Since these are skills that need to be recertified at the end of clinical training, this
certification is a “First level Certification”
Assessment
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Grade Explanation of Grade Action to be taken
B Student has performed the assessment with Re‐assessment for parts that have
minor errors that need to be rectified been performed incorrectly
D Student has not been able to perform the Re‐assessment of whole skill
assessment
(Note: columns for ‘number of attempts’ can be added in the template attached below)
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CERTIFICATION SHEET – Blank Template:
Subject:
Skill:
Competency Number:
B Student has performed the assessment with minor errors that need to be rectified
SKILL CHECKLIST
Satisfactory ( √ ), unsatisfactory ( X )
Steps Attempt Attempt Attempt ‘n’
I II ………..
Date: Date: Date:
Grade
Roll No:
Setting:
Classroom/Hospital/Community
Department visited:
Lead Dept:
Anat/Physio/Biochem
Objectives
1.
2.
3.
1. Briefly describe what you learnt from this session/ clinical visit in relation to the
objectives. (in 100‐150 words)
2. Apart from the above learning, what did you observe that influenced
(Positive/negative) you? (in 100‐150 words)
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SUGGESTED TEXT BOOKS
Note: A single text book may not cover the entire curriculum. Referring to more than one
book is recommended.
1. Guyton and Hall. Text of Medical Physiology. South Asian edition. Mario Vaz,
Anura Kurpad, Tony Raj.
2. Ganong’s Review of Medical Physiology.
3. Vander’s Human Physiology.
4. Principles of Medical Physiology. Sabyasachi Sircar
5. Text book of Medical Physiology. Indu Khurana
6. Text book of Medical Physiology. D Venkatesh, H H Sudhakar
7. Comprehensive text book of medical physiology. G K Pal. – single volume
8. Essentials of Medical Physiology. ABS Mahapatra
9. Berne and Levy Physiology. BM Koeppen, BA Stanton
10. Human Physiology. Lauralee Sherwood.
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