Anti Anxiety Drugs

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ANHIOLYTIC AND HYPNOTIC AGENTS BENZODIAZEPINES sum res ume= PAM = Allerazolom = Chlordiazepoxide = Clonazepam = Clorazepate - Diazepam = €stalozam ~ Flurazepam = Lorazepam = midazolom = Oxazepam = Quezepam = Temazepam = Triazolom ANE 15 @ Feeling of tension, nervousness, apprehension, or Feor thot sully Involves unpleasant reactions to 0 stimulus, whether actual or unknown when annlety becomes overwhelming or severe, it can, Inkerfere with the activities of daily living and lead to medical problems related te chronic stimulation of the sumpothetic nervous system. A severely anxious person may, For example, be afraid to leave the house or to interact with other people. In these: cases, treatment Is warranted. Aniolytic drugs ore rugs thot are used to lyse or break the Feeling of ennlety. Ecler ley ‘The loss of awareness and reaction to environmental stimull Is termed sedation. This condition may be desirable in patients who ore restless, nervous, irritable, oF overreacting to stimul Although sedation Is anvlolytic, e may frequently lead to drowsiness, venosis Is the extreme state of sedation, n which the person no longer senses or reacts to incoming stimull 1 Hypnotics ore used to help people Fall asleep by causing Sedation. Orups that are effective hypnotics act on the reticular activating system (RAS) and block the brain's response to Incoming stimu GABA Games Aminobutyric Acid ommo-ominobutyrle oc (y~aminobutyric acid, or GABA). {on omino acid, Is the major inbibtory neurotransmitter in the brain and nas been Found to modulate other neurotransmitter systems rather than to provide a direct stimulus. © rugs thot increose GABA function, such os benzodiazepines, are used to treat anwlety and to Induce sleep innblts too much excitatory = Reduces onniety = Relaxation = sleep = muscle retowant = Poin perception ‘Y BindswithGABA = When GABA Binds with Is receptor site, BDZ also binds thus: ‘causing the opening of the ligand-gated channels and allowing ‘more chloride lons to enter the neuron, = When chloride ions enter the neuron, it causes huperpolorization where in the inside of the neuron becomes more negative because of chloride Ions. Y Decreased Firing potentiol = ~ unen the Inside ofthe neuron is more nepetive, the fring potential decreased or tranguilzed thus, inhibitory mechanism have occurred already. = These erugs act in the limbic system and the RAS to mohe ‘gemma-aminobutyric ocid (GABA) more effective, cousing Interference with neuron Firing 'Y Sedation ond drowsiness. ? ~ umen the electrical activity of the bal s decreoses, xtreme sedation and feetng of steepness coud cou wtich is very helpful or patients with ene ADVERSE EFFECTS Depression Lethoray Blurred Vision Sleep driving Headaches. Apathy Ught-headedness Amnesio Confusion. Tis poradonical encieatory we ceccccccce GASTROINTESTINAL SYSTEM: © pry mouth

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