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    Diego Alejandro Safian Carrillo Qualifications

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    Diego Safian is a postdoctoral researcher at The Francis Crick Institute studying the cellular and molecular mechanisms underlying the evolutionary origins of the placenta in fish of the family Poeciliidae. He received his PhD in fish developmental biology from Utrecht University and has worked as a postdoc at Wageningen University. His research focuses on the convergent and divergent evolution of the placenta in fish. He has published 15 papers and reviews on fish reproduction and developmental biology.

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    Diego Alejandro Safian Carrillo Qualifications

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    Diego Safian is a postdoctoral researcher at The Francis Crick Institute studying the cellular and molecular mechanisms underlying the evolutionary origins of the placenta in fish of the family Poeciliidae. He received his PhD in fish developmental biology from Utrecht University and has worked as a postdoc at Wageningen University. His research focuses on the convergent and divergent evolution of the placenta in fish. He has published 15 papers and reviews on fish reproduction and developmental biology.

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    Diego Safian is a postdoctoral researcher at The Francis Crick Institute studying the cellular and molecular mechanisms underlying the evolutionary origins of the placenta in fish of the family Poeciliidae. He received his PhD in fish developmental biology from Utrecht University and has worked as a postdoc at Wageningen University. His research focuses on the convergent and divergent evolution of the placenta in fish. He has published 15 papers and reviews on fish reproduction and developmental biology.

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    © All Rights Reserved
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    Download as pdf or txt
    25 views3 pages

    Diego Alejandro Safian Carrillo Qualifications

    Uploaded by

    api-615670705
    Diego Safian is a postdoctoral researcher at The Francis Crick Institute studying the cellular and molecular mechanisms underlying the evolutionary origins of the placenta in fish of the family Poeciliidae. He received his PhD in fish developmental biology from Utrecht University and has worked as a postdoc at Wageningen University. His research focuses on the convergent and divergent evolution of the placenta in fish. He has published 15 papers and reviews on fish reproduction and developmental biology.

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    of 3

    Diego Alejandro Safian Carrillo

    Email: [email protected], [email protected]

    Qualifications

    08/2013-01/2019 PhD in stem cell and fish developmental biology, Reproductive Biology Group,
    Utrecht University, The Netherlands
    03/2011-10/2012 M.S. in fish endocrinology, Department of Biology, Andres Bello University,
    Chile
    03/2005-12/2010 B.S. in marine biology, Department of Biology, Andres Bello University, Chile

    Employment history

    12/2021-present Postdoctoral researcher at The Francis Crick Institute, UK


    Project: Cellular and molecular mechanisms underlying the evolutionary
    origins of the placenta in Poeciliidae
    06/2019-11/2021 Postdoctoral researcher at Wageningen University, The Netherlands
    Project: Convergent/divergent evolution of the placenta in Poeciliidae
    11/2012-07/2013 Research assistant in the Molecular Biotechnology lab at Andres Bello
    University, Chile

    Grants/awards

    2021 Registration grant to Placental biology course, University of Cambridge (£200)


    2020 Registration grant to Molecular Mechanisms in Evolution and Ecology, EMBL (£150)
    2019 Postdoctoral fellowship, ANID (£45.000)
    2013 PhD fellowship BECAS Chile, CONICYT (£100.000)
    2011 Travel grant to Congress of Marine Science, Chilean Society of Science (£250)
    2009 Bachelor grant from Andres Bello University, Chile (£800)

    Publication in peer-reviewed journals (* denote corresponding author role for SD)

    Wageningen University
    1. Safian, D, Ahmed M, Kruistum H, Furness AI, Reznick DN, Wiegertjes GF, and PolluxBJA
    (2023). Repeated independent origins of the placenta reveal convergent and divergent organ
    evolution within a single fish family (Poeciliidae). Science Advances 9, 34: eadf3915
    2. Safian, D, Wiegertjes GF, and Pollux BJA. The fish family Poeciliidae as a model to study the
    evolution and diversification of regenerative capacity in vertebrates (2021) Frontiers in Ecology
    and Evolution 9: 613157.
    3. Crespo D, Assis LHC, Zhang YT, Safian D, Coomans C, Furmanek T, Skaftnesmo KO, Norberg
    B, Ge W, Broeder M, Legler J, Bogerd J, Schulz RW (2021). Insulin-like 3 affects zebrafish
    spermatogenic cells directly and via Sertoli cells. Communications Biology. 5
    4. Sanchez J, Canales-Cerro C, Noll D, Safian D, Estrada JM (2020). Potential of Tegula atra
    (Mollusca: Gastropoda) as bioregulator of algae growth in culture tanks of the Chilean flounder
    Paralichthys adspersus. Revista de Biología Marina y Oceanografía, 5, 217-224.

    Utrecht University
    5. Crespo D, Lemos M, Zhang YT, Safian D, Norberg B, Bogerd J, Schulz RW (2020). PGE2 inhibits
    spermatogonia differentiation in zebrafish: interaction with Fsh and androgen. Journal of
    Endocrinology, 244, 163-175.
    6. Safian D, Bogerd J & Schulz RW (2019). Regulation of spermatogonial development by Fsh:
    The complementary roles of locally produced Igf and Wnt in adult zebrafish testis. General and
    Comparative Endocrinology, 284,113342. doi: 10.1016/j.ygcen.2019.113244.
    7. Crespo D, Assis L, van de Kant H, de Waard S, Safian D, Lemos M, Bogerd J & Schulz RW
    (2019). Endocrine and local signaling interact to regulate spermatogenesis in zebrafish: Follicle-
    stimulating hormone, retinoic acid and androgens. Development, doi: 10.1242/dev.178665.
    8. Safian D, Ryane N, Bogerd J & Schulz RW (2018). Fsh stimulates Leydig cell Wnt5a production,
    enriching zebrafish type A spermatogonia. Journal of Endocrinology, 239, 351-363.
    9. Safian D, Bogerd J & Schulz RW (2018). Igf3 activates β-catenin signaling to stimulate
    spermatogonial differentiation in zebrafish. Journal of Endocrinology, 238, 245-257.
    10. Safian D, van der Kant H, Crespo C, Bogerd J & Schulz RW (2017). Fsh regulates igfbp gene
    expression directly or via downstream effectors to modulate Igf3 effects on zebrafish
    spermatogenesis. Frontier in Endocrinology, 8:328. doi: 10.3389/fendo.2017.00328.
    11. Safian D, Morais RD, Bogerd J & Schulz RW (2016). Igf binding proteins protect undifferentiated
    spermatogonia in the zebrafish testis against excessive differentiation. Endocrinology, 157,
    4423-4433.

    Andres Bello University


    12. Fuentes EN, Safian D, Valdés JA, Alvarez M & Molina A (2013). Nutritional status modulates
    the Leptin/AMPK axis linked to mitochondrial biogenesis and protein synthesis/cell growth:
    implications in cell metabolism and growth in the skeletal muscle of the fine flounder. General
    and Comparative Endocrinology, 186, 172-180.
    13. Safian D, E.N. Fuentes JA Valdés & A Molina (2012). Dynamic transcriptional regulation of
    autocrine/paracrine igfbp1, 2, 3, 4, 5 and 6 in the skeletal muscle of fine flounder during different
    nutritional statuses. Journal of Endocrinology. 214; 95-108.
    14. Fuentes EN, Safian D, Valdés JA & Molina A (2012). Isolation and selection of suitable reference
    genes for real-time PCR analyses in the skeletal muscle of fine flounder in responses to
    nutritional status: assessment and normalization of gene expression of growth-related genes.
    Fish Physiology and Biochemistry. doi: 10.1007/s10695-012-9739-5.
    15. Escobar S, Fuentes E, Poblete E, Valdés JA, Safian D, Reyes A, Alvarez M & Molina A (2011).
    Molecular cloning of IGF-1 and IGF-1 receptor and their expression pattern in the Chilean
    flounder (Paralichthys adspersus). Comparative Biochemistry and Physiology, Part B:
    Biochemistry & Molecular Biology. 159: 140-147.

    Journal Reviewer

    • Development
    • Molecular and Cellular Endocrinology
    • General and Comparative Endocrinology
    • Frontiers in Immunology

    Teaching

    2020-present Lecture on placental immunology in the course “Developmental Biology”,


    Wageningen University
    2019-2020 Lecturer on fish reproduction in the course “Animal Companion”, Wageningen
    University
    2010-2011 Lecturer, course “Genetic Engineering and Biotechnology in Aquaculture”, Andres
    Bello University

    Supervision and Mentoring

    Master Supervisor of 7 master students (3 Andres Bello University; 1 Utrecht University; 2


    Wageningen University; 1 The Francis Crick Institute).
    Bachelor Supervisor of 5 bachelor students (2 Andres Bello University; 2 Utrecht University; 1
    Wageningen University).
    Technician Supervisor of 1 technical student (Utrecht University)

    Specialization courses

    2022 Analysis of bulk and single-cell RNA seq University of Cambridge, UK


    2022 Reproducible research in R University of Cambridge, UK
    2021 Unix and shell University of Cambridge, UK
    2020 RNA-seq in non-model organisms Physalia Courses, Germany
    2019 Statistics and R Utrecht University, The Netherlands
    2017 Data and image processing Utrecht University, The Netherlands
    Conference organization and working group activities

    2020-2021 Organizing member of the next 9th Conference of Poeciliidae Biology at Wageningen
    University & Research, The Netherlands
    2019 Presenter at Masterclass with Prof. David Reznick (University of California, Riverside,
    USA) and Dr. Pollux`s group (Experimental Zoology Group, Wageningen University
    & Research) at Wageningen University & Research, The Netherlands (Presentation
    title “Evolution of fin regeneration in fish: Molecular genetic mechanisms responsible
    for the evolutionary diversification of fin regeneration in Poeciliidae”
    2018 Presenter at masterclass with Prof. Ans Van Pelt (University of Amsterdam), Prof.
    Takashi Shinohara (Kyoto University), Prof. Dick de Rooij (Whitehead Institute, USA;
    Utrecht University) and Dr. Rüdiger Schulz’s group (Utrecht University) at the
    University of Amsterdam, The Netherlands (2018). Presentation title “Canonical and
    non-canonical Wnt signaling regulates spermatogonial activity in adult zebrafish
    testis”
    2009 Organizing member of the 1st Conference of Marine Biology at Andres Bello
    University, Chile

    Outreach work

    2018-2019 Columnist at the Chilean online magazine “Chile Científico” for scientific engagement
    2016-2017 Regional coordinator (Utrecht) of the Association of Chilean researchers in the
    Netherlands
    2007-2008 Organizer and instructor for courses to introduce marine life to secondary school
    students at Andres Bello University

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