Bleeding in Late Pregnancy
Bleeding in Late Pregnancy
Bleeding in Late Pregnancy
Normally ; the placenta is implanted in the upper uterine segment (60-80% posterior wall
"fundo-posterior" )
How to Differentiate that this placenta is P.P not normal rare placental implantation ?
By U/S : Depend on Distance of lower edge of placenta & internal os . If distance <2cm
minor P.P . >2cm rare site of placental normal implantation .
New classification of P.P. :
A. Minor placenta praevia : placenta sited within the lower uterine segment but not
cover the internal os .
B. Major placenta praevia : placental cover or encroaching the cervical internal os
Old I-IV classification of P.P. :
a) Grade 1 = type 1 =1st degree = P.P lateralis = low lying placenta :
the lower edge of placenta reaches the upper part of the lower uterine
segment .
b) Grade 2 = type 2 = 2nd degree = P.P marginalis :
the lower edge of the placenta reaches down to the margin of the internal os
but does not cover it .
c) Grade 3 = type 3 =3rd degree = incomplete P.P. centralis = partial P.P. :
The placenta covers the internal os when the cervix is close but not when
dilated .
d) Grade 4 = type 4 =4th degree = complete P.P. centralis =total P.P. :
the placenta covers completely the internal os whether closed or dilated .
Mechanism Of Bleeding In P.P. :
Normally ; the lower uterine segment expressing progressive stretching during 3 rd
trimester & the placenta is not elastic and cannot stretch inevitable/unavoidable
separation tearing of vascular connection between placenta and uterine wall
bleeding .
During first stage of labor : the lower uterine segment is pulled upward by
contractions and retractions of upper segment while the lower pole of membrane
together with placenta move downward " shearing movement " placental
separationbleeding .
Notes :
- In case of P.P. centralis , bleeding may occur early and usually severe because a great part
of placenta is attached to the lower uterine segment .
- P.P. marginalis posterior is of bad prognosis than marginalis anterior because :
1) it encroaches the true conjugate diameter delaying the engagement of the head
2) engagement of head will compress the placenta against the sacrum , casing fetal
asphyxia .
Predisposing factors :
1. Previous uterine surgery as in pt. with uterine myoma
2. Uterine structural anomaly
3. Assisted conception "IVF"
4. Previous cesarean section : >> Increased Number increase risk of complications "
morbid adherent of placenta"
5. Previous History of P.P.
6. Multiple pregnancy especially fused placenta "large size"
7. Multiparity "common"
8. advanced maternal age >40 "common"
9. smoking
10.Deficient endometrium due to presence or History of :
- Uterine scar
- endometriosis
- manual removal of placenta
- curettage
- submucous fibroids
Note : P.P is related to conditions existing prior to pregnancy
Signs :
A. General Examination :
- Depend on the amount of blood loss & severity of bleeding
- Recurrent gradual loss anemia
- Rapid severe blood loss hypovolemic shock "
B. Abdominal Examination P/A :
Uterus : soft , non-tender , normal size & consistency and fetal parts are easily palpable
( in contrast to revealed accidental Hg. )
The presenting part is not engaged - placenta interfere with engagement
Fetal heart sounds are heard unless more than half of placenta has separated
Fundal level correspond to the level of amenorrhea
Malpresentaion as breech & shoulder is common & Transverse and oblique lie .
Suprapubic fullness/bulge obscuring the presenting part is rarely felt with anterior P.P
Stallworthy signs : in case of posterior P.P. ; Pressure on the fetal head downward into
pelvis fetal bradycardia
C. Vaginal Examination P/V :
- Absolute contraindicated unless Major . P.P. Is excluded by U/S
- Speculum ex. to exclude local causes only permissible when major P.P is excluded .
- P/V can provide information on cervical dilatation when P.P is associated with pain or
uterine activity
- it provoke severe bleeding , so should be done with the following precautions :
(in the operating theater , under general anesthesia , cross matched blood is at hand ,
double IV set , operating theater ready for C/S . )
Investigations :
Major/massive Hemorrhage :
CBC , Rh , Blood group , kleihauer test when Rh-ve
Cross-match 6 or 4 units of blood
Urea, Electrolytes and LFT
Coagulation screen indicated only when PLT is low
CTG when stable mother or resuscitated
Ultrasonography U/S
Simplest, Safest & most accurate and most widely used method for placental
localization and diagnosis of P.P is provided by trans-vaginal U/S - accuracy : 98%
If the distance between the lower edge of Placenta & margin of internal os less
than 2cm ; it is diagnosed as minor P.P.
It determines :
type of P.P.
viability
fetal maturity are essential to decide the management .
presentation and position
congenital anomalies
Note :
- 15-20% of pregnant women exhibit a low-lying placenta in the early 2 nd trimester -
before 24 ( at 20 week scan ) ; of these, 90% resolve without symptoms & 10% develop
P.P " placental migration " . So , it's recommended to repeat U/S scan when P.P. is
diagnosed before 24 Week gestation .
- At 20 week, the lower uterine segment has not yet been formed and most low-lying
placenta will migrate upwards as the lower segment stretches in the late 2 nd and 3rd
trimesters
Warning Signs in P/P:
Low-laying placenta at 20 week anomaly scan
Maternal collapse
Feeling cold
Light-headedness, restlessness , distress
Panic & painless vaginal bleeding
Notes : Placenta previa is most dangerous for mother because bleeding is from the mother
rather than fetal circulation
Management :
P.P. is a part of obstetric emergencies that need prompt recognition & treatment to limit
morbidity and mortality .
Treatment Steps :
1. Call for help [ Senior obstetrician, Anesthetist, senior midwife, porter ] "First Action" .
2. Resuscitate using ABC "First Line"+ High-flow O2 administration + two large bore
cannula
3. Blood drawn for blood grouping, cross-matching, baseline hematology and
biochemistry
4. IV crystalloid fluids
5. Blood transfusion if severe bleeding
6. U/S
7. Definitive treatment depend on :
Maternal & fetal condition
Type of P.P.
Severity of bleeding
If P.P. present in labor or not
Fetal condition
Gestational age
A. Minor P.P
1) If preterm & the amount of bleeding is mild & the fetus uncompromised
admission for observation and evaluation & not allowed home until at least 24
hours has passed without further bleeding
- At end of 37 weeks termination & mode of delivery is vaginally .
2) If preterm with severe vaginal bleeding immediate termination after
resuscitation
3) If term Termination
B. Major P.P
- Mode of delivery : C/S
- Indications :
Massive Bleeding immediate C/S regardless of GA
After complete 37 week
Continuing significant bleeding of lesser severity
Detailed Management :
Call for help
Resuscitate the pt. using the structured approach ABC ( Airway , Breathing and
ventilation , Circulation with volume replacement ): first-line .
Airway : "maintain airway patency "
Ask a simple question, a normal voice implies an intact airway .
If no response (Look , listen & feel) . Suction of airway, chin lift head tilt , passing a
plastic oropharyngeal or nasopharyngeal airway
Breathing :
look , listen & feel then ventilate with bag-valve mask and administer of high
concentration of oxygen either mask or nasal catheter & connect the pt. to pulse
oxymeter
Circulation :
Assess pulse , BP, capillary refill , skin temperature mental status , identify any
source of bleeding …(look, listen & feel ) .
Insert IV access via two wide bore cannula in anticubital fossa, blood is drawn for
blood grouping and cross-matching, baseline hematology and biochemistry
Fluid resuscitation
Anti-shock measures as pethidine IM , fluids and blood transfusion may be given If
bleeding is severe .
Notes :
Absent breathing indicate lack of circulation CPR immediately
If circulation present but no breathing (respiratory arrest ) ventilation breaths with
high flow oxygen should be given at rate of ten breaths per minute with regular
carotid check every ten breaths
Absent circulation need immediate CPR .
Decision of definitive treatment initially depend on the maternal condition. the first
priority is to stabilize the mother .
Exclude cervical carcinoma by smear History & direct visualization of cervix
If there is minimal bleeding & the cause is clearly local vaginal bleeding ; symptomatic
management may be given ( e.g. anti-fungal for candidiasis ) .
When her condition is stable , Assessment of pt. condition , general & abdominal
examination .
Ultrasonography U/S
The definitive management depend upon :
type of P.P.
severity of bleeding
if P.P. present in labor or not
fetal condition
Gestational age
A. If there is major maternal or fetal compromise immediate delivery regardless
of gestational age + steroid injection
B. If pt. Dx by U/S as minor P.P. ; we Look if this pregnant women preterm or term &
with mild or sever vaginal bleeding .
1) if preterm & the amount of bleeding is mild & the fetus uncompromised
admission for observation and evaluation " and not allowed home until at
least 24 hours (or 48h)has passed without further bleeding .
Evaluate for :
☆ Recurrent vaginal bleeding
☆ Correct anemia with blood transfusion
☆ Rh group ( if negative : send a kleihauer test & mandatory given anti-D ),
☆ Observation of fetal well-being .
☆ If bleeding is substantial in excess of 500 ml maternal corticosteroids
is considered if under 35 years .
☆ Conservative treatment is indicated till the end of 37 weeks but not
more & the mode of delivery is vaginal .
2) If preterm with severe vaginal bleeding : require resuscitation & immediate
termination of pregnancy by CS .
3) If term : Immediate delivery " vaginal " ( no observation )
C. If pt. Dx by U/S as major P.P. :
All the cases of major P.P. must be delivered by C/S .
Indications for delivery by C/S :
- Massive bleeding > 1500 mL regardless of Gestational age - need immediate CS .
- Term fetus after complete 37 weeks
- Continuing significant bleeding of lesser severity
Complications Of Placenta Praevia :
C. Maternal Complications : A. Fetal Complications :
1. Morbid adherent of placenta 1. Prematurity
2. PPH : Due to 2. Asphyxia
- weak contractions and retractions in LUS 3. IUGR
- Uterine atonia due anemia 4. IUFD
3. Hypovolemic shock 5. Cord prolapse
4. Renal failure B. Effect on Puerperium :
5. Complications for surgery & anesthesia 1. Retained part of placenta
6. Non-engagement 2. puerperal sepsis
7. Preterm labour 3. Anemia
8. Malpresentations 4. Sub-involution
9. Higher incidence of C/S & it is complications 5. Sheehan syndrome
- Partial or total absence of the spongy layer of decidua basalis and imperfect development
of the fibrinoid or Nitabuch layer absent physiological line of cleavage Placental villi
attach to smooth muscle fibers rather than to decidual cells prevent normal placental
separation after delivery
Classification :
3 Types :
1. Placenta Accreta (78%) : The placenta is abnormally adherent to the uterine wall
- villi are attached to the myometrium
2. Placenta Increta (17%) : Placenta is abnormally invade to the uterine wall
- villi actually invade the myometrium
3. Placenta Percreta (5%) : Placenta is invading through the uterine wall
- villi penetrate through myometrium and to or through serosa
Adherence may be :
Risk factors :
1) P.P
2) Previous C/S ( Increase with increased number of CS )
3) Combination of the two
4) Curettage & endometrial ablation
5) Risk markers : MSAFP levels >2.5 MoM , Maternal serum free B-hCG >2.5 MoM
Complications :
Pregnancy Outcomes :
1)
Complications of retained placenta :
1)
Placental Abruption=Accidental Hemorrhage=Abruptio Placenta
Premature(befre 3rd stage of labour ) separation of the normally implanted placenta
from the uterine wall .
The bleeding is maternal and/or fetal and is acutely dangerous for both fetus and mother
Etiology/Predisposing factors :
Types :
1) Revealed : most cases 2/3
- the separation reach the edge of the placenta tracks down to the cervix
2) concealed/hidden
- significant separation between the placenta and uterus but blood in trapped between the
placenta and uterus so there is little vaginal bleeding seen
- main C/P is sever constant abdominal pain "main" + fetal distress + maternal shock
without any obvious bleeding
Diagnosis : mainly based on the clinical grounds . Pain is a constant feature In all
cases
Symptoms :
- sudden onset Dark painful vaginal bleeding . it can be concealed , so its absence doesn’t
exclude AP.( the degree of vaginal bleeding does not correlate with the degree of abruption
as it may be concealed )
- frequent short lasting uterine contractions " irritable effect of blood in uterus
- reduced/absent fetal movements & CTG non-reassuring fetal heart rate pattern
signs :
P/A :
- Tense rigid tender uterus " woody hard uterus " = " Couvelaire=apoplexy uterus" due to
large volume of blood within the myometrium "mostly in concealed type"
- tense rigid abdomen " the absence of that does not exclude AP "
- the uterus is large than the period of amenorrhea
1- exclude PP
Differential Dx :
1- concealed must be D.D from other causes of acute abdominal pain during pregnancy
Complications :
1) hypovolemic shock
2) DIC " 2ry phenomenon due to generalized activation of coagulation system "
3) Acute Renal failure " pt. oliguric or ATN "
4) fetomaternal hemorrhage
5) perinatal mortality
6) FGR
7) prematurity
8) Sheehan's syndrome
Management :
1. Resuscitation using ABC "life-threating emergency"
2. Depend on severity :
- in severe cases :
if fetus alive C/S
if died Vaginal delivery
- in mild cases : admission & observation " conservative"
Depend on type :
A. Revealed type (on severity of bleeding ) :
1. sever bleeding :
- correction of shock
- C/S
2. mild bleeding :
a) pt. is in labour
- Amniotomy & oxytocin drip for spontaneous vaginal delivery
b) pt. is not in labour
- mature : Termination by amniotomy and oxytocin drip
- premature : conservative ttt. until maturity then termination
B. Concealed type :
1. correction of shock
2. termination of pregnancy :
fetus alive : immediate C/S
fetus died : Vaginally by amniotomy and oxytocin drip
Vasa praevia
occurs when fetal blood vessels traverse the fetal membrane over the internal cervical os .
Vasa previa is not dangerous for the mother but is nearly always fatal for the baby .
Management :
Types :
1- primary PPH :
2- secondary PPH :
- Any vaginal bleeding post-delivery compromise the maternal condition (CV compromise –
{tachycardia, hypotension, slow capillary refill, dry and pale skin ) or a continuing bleeding
even if estimated losses < 1000 protocols should be instituted .
- blood loss ≥2500 ml or requiring blood transfusion ≥5 units RBC or need ttt. of
coagulopathy .
Risk factors
- causes :
- all types of delivery cause some degree of genital tract trauma in form of perineal &
vaginal tear " most common after forceps delivery"
causes :
Forceps extraction
breech extraction
4. Thrombotic : clotting disorders "more rarely"
- women with Von-Willebran's disease or PLTs disorders excessive blood loss
[ massive placental abruption ,unidentified died fetus , amniotic fluid embolus , massive
hemorrhage ]
Diagnosis :
Early recognition of blood loss
rapid action
appreciation of risk factors
accurate estimation of blood loss
recognition of maternal cardiovascular compromise
symptoms :anxiety , thirst , nausea , cold, pain, dizziness
General examination : a variable degree of shock is present , according to amount of
blood loss .
[ reduced urine output – tachypnea-tachycardia-hypotension-narrow pulse pressure ]
Abdominal examination :-
- rising fundus
- peritonism
-in atonic PPH : the uterus is soft and enlarged than expected leads to gush of
clotted blood per vagina
- in traumatic PPH : the uterus is firm & well contracted
Local(vaginal) examination :
- atonic :
Bleeding start after minutes form delivery of fetus
Dark & red color
The placenta may not be delivered
- Traumatic :
bleeding start immediately after delivery of fetus
Bright & red color
lacerations can be detected
Management :
Prophylactic treatment :
A. Antenatal :
- treatment of anemia
- Pt. at high risk of PPH Instruct that delivery must be at hospital
B. Intrapartum :
- Expect PPH in vulnerable groups
- Active management of third stage of labour
- After the placenta is delivered;
Active treatment :
1. Call for help [ Senior obstetrician, Anesthetist, senior midwife, porter ] "First Action" .
2. Resuscitate using ABC "First Line"+ High-flow O2 administration by mask + two large
bore cannula
3. Blood drawn for blood grouping, cross-matching 6 units at least , baseline hematology
and biochemistry
4. IV crystalloid fluids
5. Foly catheter into bladder & fluid balance chart
6. Blood transfusion : Uncross matched same group as mother or extreme case O –ve
7. Try to identify the cause
Hx
-
Ex
-
8. If Atonic PPH :
A. Give Uterotonic drugs e.g. PGs , Oxytocin …
B. If failed; apply a uterine massage
C. If failed; perform Bimanual uterine compression ( If contraction appear , maintain for
5 minutes )
D. If failed; perform uterine tamponade or balloone cateter
E. If failed; transport to operating theater, in which these procedures are performed :
1. Re-evaluation
2. Laparotomy ( B-Lynch suturing – Multiple sutures in uterus )
3. Bilateral ligation of Uterine artery
4. Bilateral ligation of internal iliac artery
5. Hysterectomy "Last"
Complications :
A. Immediate
1.
B. Late
🔰 *Postpartum hemorrhage*
🔴 Practical definition:
- Any bleeding associated with sings & symptoms of Cardiovascular compromise
🔴 Types :
1- Retained Separated
2- Retained Unseparated
🔴 Retained Separated :
- Defect in descend & expulsion staged
- Causes: ( No contraction)
1) Uterine atony
2) Contraction ring
- Dx:
1) Vaginal bleeding
2) Uterus somewhat contracted
🔴 Retained Unseparated :
- Defect in separation
- Causes:
1) Uterine atony
2) Morbid adherent placenta
- Dx:
1) No Vaginal bleeding
2) Uterus soft
🔴 Management:
1) Embty the bladder (Fisrt line )
2) Retroatoinc drugs
3) Apply gentle traction of cord
4- Operation room ( Manual removal ) under general anesthesia
🔰 *Uterine inversions ;*
🔴 Defined as descending of the uterine fundus into the uterine cavity , cervix or
vagina , or protruded from vagina
🔴 Causes:
1- miss managed 3rd stage ( retracting the cord while the placenta is still attached )
2-short cord(fundal placenta)
3- Morbid adherent placenta
🔴 Diagnosed by :
1- Signs of CVS collapse
- Hypovolemic shock due to bleeding
- Neurogenic shock due to traction of sympathetic system ( tracrion on sympathatic
nerve)
2- Hemorrhage
3-Inverted uterus
4-Felling of dimple
🔴 Management:
1. Resuscitate using ABC
2. If the placenta is still attached don’t remove the placenta until replacing the uterus
3. Immediate Manual replacement
4. Replace under anesthesia
5. Hydrostatic pressure ( fluid causing ballooning of the vagina and correction of
inversion )
6. Surgical procedure by roand ligament
🔴 **تعديل
Uterine apoplexy - Complication of *Placenta aperture*