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    Infusions 1

    Uploaded by

    Mohammed Ibrahim
    This document provides guidelines for infusion rates of various medications including: 1. Diuretics such as furosemide and torasemide at rates of 0.5-4 ml/hr and 5-20 ml/hr respectively. 2. Vasodilators such as nitroglycerin, sodium nitroprusside, and nitroprusside at rates between 0.3-21 ml/hr depending on the medication and intended use. 3. Anticoagulants including heparin, enoxaparin, tirofiban, and eptifibatide with loading and maintenance doses calculated based on patient weight and medication concentration.

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    Infusions 1

    Uploaded by

    Mohammed Ibrahim
    9 views4 pages
    This document provides guidelines for infusion rates of various medications including: 1. Diuretics such as furosemide and torasemide at rates of 0.5-4 ml/hr and 5-20 ml/hr respectively. 2. Vasodilators such as nitroglycerin, sodium nitroprusside, and nitroprusside at rates between 0.3-21 ml/hr depending on the medication and intended use. 3. Anticoagulants including heparin, enoxaparin, tirofiban, and eptifibatide with loading and maintenance doses calculated based on patient weight and medication concentration.

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    Infusions-1

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    This document provides guidelines for infusion rates of various medications including: 1. Diuretics such as furosemide and torasemide at rates of 0.5-4 ml/hr and 5-20 ml/hr respectively. 2. Vasodilators such as nitroglycerin, sodium nitroprusside, and nitroprusside at rates between 0.3-21 ml/hr depending on the medication and intended use. 3. Anticoagulants including heparin, enoxaparin, tirofiban, and eptifibatide with loading and maintenance doses calculated based on patient weight and medication concentration.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    9 views4 pages

    Infusions 1

    Uploaded by

    Mohammed Ibrahim
    This document provides guidelines for infusion rates of various medications including: 1. Diuretics such as furosemide and torasemide at rates of 0.5-4 ml/hr and 5-20 ml/hr respectively. 2. Vasodilators such as nitroglycerin, sodium nitroprusside, and nitroprusside at rates between 0.3-21 ml/hr depending on the medication and intended use. 3. Anticoagulants including heparin, enoxaparin, tirofiban, and eptifibatide with loading and maintenance doses calculated based on patient weight and medication concentration.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 4

    INFUSIONS

    A] Furosemide (Lasix)
    5 – 40 mg /hr
     12 ampoules (40 mg/4 ml) at rate 0.5 – 4 ml/hr
     1 ml = 10 mg
    B] Torasemide (Examide_
    5 – 20 mg/h
     5 ampoules (10 mg) over 50 cc saline at rate 5-20 ml/hr
     1 ml = 1 mg

    C] GTN (Tridil, Nitronal)


    5 – 200 µg/min up to 300 µg/min
     1 vial (50 mg/ 50 ml) at rate 0.3 – 12 ml/hr
     AC$: 0.6-1.5 ml/hr
     HTN, APO: up to 21 ml/hr
     1 ml = 1 mg = 1000 µg
     5 µg/min = 300 µg/hr = 0.3 ml/hr
     200 µg/min = 12000 µg/hr = 12 ml/hr
     300 µg/min = 18000 µg/hr = 18 ml/hr
    D] Na Nitroprusside (Niprid)
    0.25-10 µg/kg/min
     Vial (60 mg) over 50 cc saline
     1 ml = 1200 µg
     Rate = dose X wt X 60 / 1200
     Caution in severe hepatic or renal impairment

    E] Heparin
    PE 80 U/Kg, 18 U/kg/hr
    AC$ 60 U/Kg, 15 U/kg/hr
     1 ampoule (5000 U) over 50 cc saline
     Loading = 1 ampoule bolus
     Maintenance = dose X body weight / concentration (= 100)
     FUP PTT / 12 hrs, FUP platelets daily
     1 ml = 100 U
    F] Enoxaparin

     Therapeutic: 1 mg/kg/12 hrs SC or 1.5 mg/kg/24 hrs SC


     Age > 75 years: 0.75 mg/kg/12 hrs
     During PCI: 0.5 mg/kg bolus then continue SC
     Prophylactic: 40 mg/24 hrs
     CrCl <30ml/min: dose given / 24 hrs
    G] Tirofiban (Aggrastat)
    Loading: 25 µg/kg over 3 mins
    Maintenance: 0.15 µg/kg/min for up to 18 hrs
    Non-interventional dose
    Loading: 0.4 µg/kg/min over 30 mins
    Maintenance: 0.1 µg/kg/min

     Vial + 200 cc dextrose = 1ml contains 50 µg drug.


     Loading dose = 25 X wt /50
     Maintenance dose = 0.15 X body weight X 60 / 50
     For a 70-kg adult with normal renal functions
     Loading = 35 ml over 3 mins
     Maintenance = 12.6 ml/hr
     CrCl <30 ml/min  decrease maintenance dose by 50%
     CBC at baseline, 4 hrs & daily

    H] Eptifibatide (Integrlin)
    Loading: 180 µg/kg double bolus 10 min apart
    Maintenance: 2 µg/kg/min for up to 18 hrs
     Small vial = 2 mg/ml, Large vial = 0.75 mg/ml
     Loading dose (from small vial) = 180 X wt / 2000
     Maintenance dose (from large vial) = 2 X wt X 60 / 750
     For a 70-kg adult with normal renal functions
     Loading from small vial = 6.3 ml
     Loading from large vial = 16.8 ml
     Maintenance from small vial = 4.2 ml/hr
     Maintenance from large vial = 11.2 ml/hr
     CrCl 30-50  decrease maintenance dose by 50%
     CrCl < 30  contraindicated
     CBC at baseline, 4 hrs & daily

    I] Dobutamine (Dobutrex)
    2.5 - 30 µg/kg/min
     β1 & β2 agonist  positive inotropic & chronotropic effect. Vasodilator effect
     Ampoule (250 mg) over 50 cc saline
     1 ml = 5000 µg
     Rate = dose X weight X 60 / 5000
     For an 80-kg adult
     Rate ranges from 2.4 ml/hr to 28.8 ml/hr
     Side effects:
    1. Down regulation of β receptors
    2. ↓ Ca2+ content of sarcoplasmic reticulum
    3. ↑ cAMP  arrhythmia
    4. Initial hypotension (not given if ABP < 70/40 unless with vasopressor)
    J] Dopamine
    Diuretic dose (D1): 3-5 µg/kg/min
    Inotropic dose (β1): 5-10 µg/kg/min
    Vasopressor dose (α1): 10-25 µg/kg/min
     Ampoule (200 mg) over 50 cc saline
     1 ml = 4000 µg
     Rate = dose X weight X 60 / 4000
     For an 80-kg adult
     Rate ranges from 3.6 ml/hr to 30 ml/hr

    K] Norepinephrine (Levophed)
    0.01 – 1 µg/kg/min
     Mainly α1 agonist, weak β1 effect
     Ampoule 8 mg over 50 cc saline  1 ml = 160 µg
     Ampoule 4 mg over 50 cc saline  1 ml = 80 µg
     For an 80-kg adult
     Rate ranges from 0.3 to 30 ml/hr (8 mg ampoule)
     Rate ranges from 0.6 to 60 ml/hr (4 mg ampoule)

    L] Adrenaline
    0.05 – 1 µg/kg/min
     6 ampoules (1 mg) over 50 cc saline
     1 ml = 120 µg
     Rate = dose X weight X 60 / 120
     For an 80-kg adult
     Rate ranges from 2 to 40 ml/hr

    M] Lidocaine
    Loading: 1-1.5 mg/kg over 2-3 mins
    Maintenance: 1-4 mg/min [3 to 12 ml/hr]

    N] Amiodarone (Cordarone)
    Loading bolus: 5 mg/kg over 1 hour
    Maintenance infusion: 50mg/hr for 24 hours
     1 ampoule = 150 mg
     Bolus: 3 ampoules (450 mg) over 30 min!!!
     Maintenance: 4 ampoules (600 mg) over 50 cc saline at rate 4.2 ml/hr to be repeated once
     Oral maintenance: 2X3X7 then 1X3X7 then 1X1
    O] Pantoprazole (Controloc)
    8 mg/hr = 10 ml/hr

    P] Insulin
    0.1 U/kg/hr
     50 units over 50 cc saline

    Q] Midazolam (Dormicum)
     3 ampoules (3 X 15 mg) + 45 cc saline
     Start with1 ml/hr & gradually titrate the dose

    R] Fentanyl
    50 µg/hr
     1 ampoule = 100 µg
     3 ampoules over 50 cc  1 cc = 6 µg

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