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    Antifibrotics

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    Elisa
    1. The document discusses two drugs for the treatment of idiopathic pulmonary fibrosis: pirfenidone and nintedanib. 2. Pirfenidone inhibits TGF-beta mediated effects and growth factors involved in fibroblast proliferation and collagen synthesis. Common side effects include nausea, diarrhea, abdominal pain, and vomiting. 3. Nintedanib is a tyrosine kinase inhibitor that blocks signaling of platelet-derived growth factor receptor, fibroblast growth factor receptor and vascular endothelial growth factor receptor. It is commonly associated with diarrhea, nausea, vomiting, abdominal pain and liver enzyme elevations.

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    © All Rights Reserved
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    Antifibrotics

    Uploaded by

    Elisa
    6 views4 pages
    1. The document discusses two drugs for the treatment of idiopathic pulmonary fibrosis: pirfenidone and nintedanib. 2. Pirfenidone inhibits TGF-beta mediated effects and growth factors involved in fibroblast proliferation and collagen synthesis. Common side effects include nausea, diarrhea, abdominal pain, and vomiting. 3. Nintedanib is a tyrosine kinase inhibitor that blocks signaling of platelet-derived growth factor receptor, fibroblast growth factor receptor and vascular endothelial growth factor receptor. It is commonly associated with diarrhea, nausea, vomiting, abdominal pain and liver enzyme elevations.

    Original Description:

    Drugs used in the treatment of Idiopathic Pulmonary Fibrosis

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    1. The document discusses two drugs for the treatment of idiopathic pulmonary fibrosis: pirfenidone and nintedanib. 2. Pirfenidone inhibits TGF-beta mediated effects and growth factors involved in fibroblast proliferation and collagen synthesis. Common side effects include nausea, diarrhea, abdominal pain, and vomiting. 3. Nintedanib is a tyrosine kinase inhibitor that blocks signaling of platelet-derived growth factor receptor, fibroblast growth factor receptor and vascular endothelial growth factor receptor. It is commonly associated with diarrhea, nausea, vomiting, abdominal pain and liver enzyme elevations.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    6 views4 pages

    Antifibrotics

    Uploaded by

    Elisa
    1. The document discusses two drugs for the treatment of idiopathic pulmonary fibrosis: pirfenidone and nintedanib. 2. Pirfenidone inhibits TGF-beta mediated effects and growth factors involved in fibroblast proliferation and collagen synthesis. Common side effects include nausea, diarrhea, abdominal pain, and vomiting. 3. Nintedanib is a tyrosine kinase inhibitor that blocks signaling of platelet-derived growth factor receptor, fibroblast growth factor receptor and vascular endothelial growth factor receptor. It is commonly associated with diarrhea, nausea, vomiting, abdominal pain and liver enzyme elevations.

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    © All Rights Reserved
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    Download as pdf or txt
    of 4

    ANT- FI8ROTC AGENTS :

    Jheu an dug formulolbd for tha datmend of ldiopadhic


    |Padomossaydug
    Sbvori iPr)
    ae: PIRFENIDONE NINE DANIB

    Nitkdanib:

    Jyeine kiuau Pubibitor


    ea- Vaawlan eudoheta qhowth
    Fhvo blast qrowth to nuuptom (R4FR),
    Platut chuived qrowth fat uton (PDGP)
    ATP bivdug potted of the
    uuptons’ boche Buraellula
    blocke eatractlula ianaling.’ bockt

    Pha aco kineds:


    Bioavailabilkly :

    Prak pasma duwakon: Q-4 kous


    Poteh- bound :
    CYP 3A 4
    Chamit fbvoring IA.
    2. sclnoh akoiald

    VomPhng, V apph, eualid lun


    Jkiu us.

    Aeigkd loM, kuadauk hyputenio, bludiag


    olganes, baut paia.
    Rare
    Preunania , dung vuoplasn puenamu

    PIREENIDONA

    MoA : bela iuhibit


    uhibit valifeaton dliflruhata
    ike uf
    cel faakiems TNE-0 ’
    ynthesis of
    Paaoinekes
    Paotin bound : 5%
    Bution Rnat A%)
    lu:
    laispodhie Punovauy

    - Conmon
    Gl icde efei - ana, diauhoca, abouiua! pain,
    V¡m ithag, GeRR, Clysepria, apphle
    Faliaui, digiaes, uRn, Baueiti
    Rash.
    - hes. oomoM

    nemnta, wught los, dysquuta, anthralia .


    - Rau

    laiopathic Palmaonay sbvory CE)

    (u) Chauaceusd
    by cuonic siamng of hu ugí, shich
    Cause
    Ruk foutors :
    Gusklug, Nge >boyeau, Mau qeuca, GeRR,
    ufuttn.

    fxuhenal dysmmota, y cough


    Gu exauiuaton:
    Vleno Aalu

    Chubing
    PET T2c, FRC, VRV, FEU EVC Aato.
    2 Chut xs- Retieulaa opauitutomy- combeg.
    3. HRT -
    Peuiphual Ntulan iafbala, toney- combing.
    Jratn byonchiutasu
    nuhophil, eomaophik,
    t aloestaa waucphages
    5

    Jaotuent
    phamaacologial Coaticoteuotd1, N-autyl ayatine,
    Q.
    Mdon planaulsqial: kung hamapkutaton, Rhabibitton

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