SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

Revision Date 05.11.2010 Version 10.2

1. Identification of the substance/mixture and of the company/undertaking

1.1 Product identifier
Catalogue No. 106146
Product name Isobutyl methyl ketone for extraction analysis EMSURE® ACS,Reag.
Ph Eur
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.

1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Reagent for analysis, Chemical production
For additional information on uses please refer to the Merck Chemicals
portal (www.merck-chemicals.com).

1.3 Details of the supplier of the safety data sheet

Company Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0
Responsible Department EQ-EPS * e-mail: [email protected]

1.4 Emergency telephone Please contact the regional Merck representation in your country.
number

2. Hazards identification
2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
Flammable liquid, Category 2, H225
Acute toxicity, Category 4, Inhalation, H332
Specific target organ toxicity - single exposure, Category 3, H335
Eye irritation, Category 2, H319
For the full text of the H-Statements mentioned in this Section, see Section 16.

Classification (67/548/EEC or 1999/45/EC)

F; R11
Xn; R20
Xi; R36/37
For the full text of the R-phrases mentioned in this Section, see Section 16.

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Page 1 of 10
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 106146

Product name Isobutyl methyl ketone for extraction analysis EMSURE® ACS,Reag. Ph Eur

2.2 Label elements

Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms

Signal word
Danger

Hazard statements
H225 Highly flammable liquid and vapour.
H332 Harmful if inhaled.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
EUH066 Repeated exposure may cause skin dryness or cracking.

Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.

Reduced labelling (≤125 ml)

Hazard pictograms

Signal word
Danger

Index-No. 606-004-00-4

Labelling (67/548/EEC or 1999/45/EC)

Symbol(s) F Highly flammable
Xn Harmful
R-phrase(s) 11-20-36/37-66 Highly flammable. Harmful by inhalation. Irritating to eyes
and respiratory system. Repeated exposure may cause skin
dryness or cracking.
S-phrase(s) 9-16-29 Keep container in a well-ventilated place. Keep away from
sources of ignition - No smoking. Do not empty into drains.
EC-No. 203-550-1 EC Label
Reduced labelling (≤125 ml)
Symbol(s) F Highly flammable
Xn Harmful
R-phrase(s) 20 Harmful by inhalation.

2.3 Other hazards

None known.

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SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 106146

Product name Isobutyl methyl ketone for extraction analysis EMSURE® ACS,Reag. Ph Eur

3. Composition/information on ingredients
Formula (CH₃)₂CHCH₂COCH₃ C₆H₁₂O (Hill)
CAS-No. 108-10-1
Index-No. 606-004-00-4
EC-No. 203-550-1
Molar mass 100,16 g/mol

4. First aid measures

4.1 Description of first aid measures
After inhalation: fresh air. If breathing stops: mouth-to-mouth breathing or artificial respiration.
Oxygen if necessary. Immediately call in physician.
After skin contact: wash off with plenty of water. Remove contaminated clothing.
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Call a physician
immediately. In case of spontaneous vomiting: Risk of aspiration. Pulmonary failure possible.
Call in physician. Subsequently administer: activated charcoal (20 - 40 g in 10% slurry). No milk.
No digestible oils.

4.2 Most important symptoms and effects, both acute and delayed
irritant effects, Cough, Shortness of breath, Dizziness, narcosis, inebriation, Nausea,
Stomach/intestinal disorders, Headache
Drying-out effect resulting in rough and chapped skin.
The following applies to ketones in general: when vapours/aerosols occur, mucosal irritations,
coughing, and dyspnoea after inhalation. The absorption of large quantities leads to: CNS
depression (narcosis). Repeated skin contact leads to a degreasing effect, with secondary
inflammation possible. Toxic effects on the liver and kidneys cannot be excluded after high
doses. The inhalation of droplets may result in the formation of oedemas in the respiratory tract.

4.3 Indication of immediate medical attention and special treatment needed

Laxative: Sodium sulfate (1 tablespoon/1/4 l water).

5. Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Carbon dioxide (CO₂), Foam, Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture

Combustible material, Vapours are heavier than air and may spread along floors.
Forms explosive mixtures with air at ambient temperatures.
Pay attention to flashback.
Development of hazardous combustion gases or vapours possible in the event of fire.

5.3 Advice for firefighters

Special protective equipment for fire-fighters
In the event of fire, wear self-contained breathing apparatus.

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SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 106146

Product name Isobutyl methyl ketone for extraction analysis EMSURE® ACS,Reag. Ph Eur

Further information
Cool closed containers exposed to fire with water spray. Prevent fire extinguishing water from
contaminating surface water or the ground water system.

6. Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance
contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency
procedures, consult an expert.
Advice for emergency responders: Protective equipment see section 8.

6.2 Environmental precautions

Do not empty into drains. Risk of explosion.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills.
Observe possible material restrictions (see sections 7.2 and 10.5).
Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of properly. Clean up
affected area.

6.4 Reference to other sections

Indications about waste treatment see section 13.

7. Handling and storage

7.1 Precautions for safe handling
Observe label precautions.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition. Take precautionary
measures against static discharge.

7.2 Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and
sources of ignition. Protected from light.
Storage temperature: no restrictions.

7.3 Specific end uses

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.

8. Exposure controls/personal protection

8.1 Control parameters

8.2 Exposure controls

Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.

See section 7.1.

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SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 106146

Product name Isobutyl methyl ketone for extraction analysis EMSURE® ACS,Reag. Ph Eur

Individual protection measures

Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Hygiene measures
Change contaminated clothing. Preventive skin protection recommended. Wash hands after
working with substance.
Eye/face protection
Safety glasses
Hand protection
splash contact:
Glove material: butyl-rubber
Glove thickness: 0,7 mm
Break through time: > 240 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 898 Butoject® (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374
with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment:
Flame retardant antistatic protective clothing
Respiratory protection
required when vapours/aerosols are generated.
Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.

Environmental exposure controls

Do not empty into drains.
Risk of explosion.

9. Physical and chemical properties

9.1 Information on basic physical and chemical properties
Form liquid

Colour colourless

Odour characteristic

Odour Threshold No information available.

pH at 20 °C
neutral

Melting point -84 °C

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SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 106146

Product name Isobutyl methyl ketone for extraction analysis EMSURE® ACS,Reag. Ph Eur

Boiling point/boiling range 116 - 118 °C

at 1.013 hPa

Flash point 14 °C
Method: DIN 51755 Part 1

Evaporation rate No information available.

Flammability (solid, gas) No information available.

Lower explosion limit 1,2 %(V)

Upper explosion limit 8,0 %(V)

Vapour pressure 20 hPa

at 20 °C

Relative vapour density 3,46

Relative density 0,80 g/cm³

at 20 °C

Water solubility 18 - 20 g/l

at 20 °C

Partition coefficient: n- log Pow: 1,31

octanol/water Method: (experimental)
(Lit.) No remarkable bioaccumulation potential is expected (log
Pow 1-3).

Autoignition temperature No information available.

Decomposition temperature No information available.

Viscosity, dynamic 0,59 mPa.s

at 20 °C

Explosive properties No information available.

Oxidizing properties No information available.

9.2 Other data

Ignition temperature 460 °C

10. Stability and reactivity

10.1 Reactivity
Vapours may form explosive mixture with air.

10.2 Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

10.3 Possibility of hazardous reactions

Strong oxidizing agents, Reducing agents, Bases
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SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 106146

Product name Isobutyl methyl ketone for extraction analysis EMSURE® ACS,Reag. Ph Eur

10.4 Conditions to avoid

Warming.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.

10.5 Incompatible materials

rubber, various plastics, Copper

10.6 Hazardous decomposition products

Peroxides

11. Toxicological information

11.1 Information on toxicological effects
Acute oral toxicity
LD50 rat
Dose: 2.080 mg/kg
(RTECS)
Symptoms: Risk of aspiration upon vomiting., Aspiration may cause pulmonary oedema and
pneumonitis., Stomach/intestinal disorders
absorption

Acute inhalation toxicity

LC50 rat
Dose: 8,3 - 16,6 mg/l, 4 h
(External MSDS)
Symptoms: mucosal irritations, Cough, Shortness of breath, absorption
Acute dermal toxicity
LD50 rabbit
Dose: > 16.000 mg/kg
(IUCLID)

absorption

Skin irritation
slight irritation Drying-out effect resulting in rough and chapped skin.
Repeated exposure may cause skin dryness or cracking.
Eye irritation
Causes serious eye irritation.
Sensitisation
Sensitisation test (Magnusson and Kligman):
Result: negative
Method: OECD Test Guideline 406

Genotoxicity in vivo
Mutagenicity (mammal cell test): micronucleus.
Result: negative
(IUCLID)
Genotoxicity in vitro
Ames test
Result: negative
(IUCLID)

The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 7 of 10
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 106146

Product name Isobutyl methyl ketone for extraction analysis EMSURE® ACS,Reag. Ph Eur

Specific target organ toxicity - single exposure

May cause respiratory irritation.

Specific target organ toxicity - repeated exposure

The substance or mixture is not classified as specific target organ toxicant, repeated exposure.
Aspiration hazard
No aspiration toxicity classification

11.2 Further information

Further information
Systemic effects:
Dizziness, Headache, inebriation, Nausea, narcosis
Other information
The following applies to ketones in general: when vapours/aerosols occur, mucosal irritations,
coughing, and dyspnoea after inhalation. The absorption of large quantities leads to: CNS
depression (narcosis). Repeated skin contact leads to a degreasing effect, with secondary
inflammation possible. Toxic effects on the liver and kidneys cannot be excluded after high
doses. The inhalation of droplets may result in the formation of oedemas in the respiratory tract.
Further data:
Handle in accordance with good industrial hygiene and safety practice.

12. Ecological information

12.1 Toxicity
Toxicity to fish
LC50
Species: Pimephales promelas (fathead minnow)
Dose: 505 - 540 mg/l
Exposure time: 96 h
(IUCLID)
Toxicity to daphnia and other aquatic invertebrates.
EC5
Species: E.sulcatum
Dose: 447 mg/l
Exposure time: 72 h
(maximum permissible toxic concentration) (Lit.)
EC50
Species: Daphnia magna (Water flea)
Dose: 170 mg/l
Exposure time: 48 h
(IUCLID)
Toxicity to algae
IC5
Species: Scenedesmus quadricauda (Green algae)
Dose: 725 mg/l
Exposure time: 7 d
(maximum permissible toxic concentration) (Lit.)
IC50
Species: Pseudokirchneriella subcapitata (green algae)
Dose: 400 mg/l
Exposure time: 96 h
(IUCLID)

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SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 106146

Product name Isobutyl methyl ketone for extraction analysis EMSURE® ACS,Reag. Ph Eur

Toxicity to bacteria
EC50
Species: Photobacterium phosphoreum
Dose: 80 mg/l
Exposure time: 5 min
(Lit.)
EC5
Species: Pseudomonas putida
Dose: 275 mg/l
Exposure time: 16 h
(Lit.)
12.2 Persistence and degradability
Biodegradability
Result: Readily biodegradable.
99 %
Exposure time: 7 d
Method: OECD Test Guideline 301E
Theoretical oxygen demand (ThOD)
2.720 mg/g

Ratio COD/ThBOD
79 %

12.3 Bioaccumulative potential

Partition coefficient: n-octanol/water
log Pow: 1,31
Method: (experimental)
(Lit.) No remarkable bioaccumulation potential is expected (log Pow 1-3).
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Additional ecological information
Do not allow to run into surface waters, wastewater, or soil.

13. Disposal considerations

Waste treatment methods
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.

14. Transport information

ADR/RID
UN 1245 METHYL ISOBUTYL KETONE, 3, II
IATA
UN 1245 METHYL ISOBUTYL KETONE, 3, II
IMDG
UN 1245 METHYL ISOBUTYL KETONE, 3, II
EmS F-E S-D

The Safety Data Sheets for catalogue items are available at www.merck-chemicals.com
Page 9 of 10
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Catalogue No. 106146

Product name Isobutyl methyl ketone for extraction analysis EMSURE® ACS,Reag. Ph Eur

The transport regulations are cited according to international regulations and in the form
applicable in Germany. Possible national deviations in other countries are not considered.

15. Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
EU regulations
Major Accident Hazard 96/82/EC
Legislation Highly flammable
7b
Quantity 1: 5.000 t
Quantity 2: 50.000 t
Occupational restrictions Take note of Dir 94/33/EC on the protection of young people at
work. Take note of Dir 92/85/EEC on the safety and health at work
of pregnant workers.

National legislation
Storage class VCI 3 Flammable Liquids

15.2 Chemical Safety Assessment

For this product a chemical safety assessment was not carried out.

16. Other information

Full text of H-Statements referred to under sections 2 and 3.
H225 Highly flammable liquid and vapour.
H319 Causes serious eye irritation.
H332 Harmful if inhaled.
H335 May cause respiratory irritation.
Full text of R-phrases referred to under sections 2 and 3
R11 Highly flammable.
R20 Harmful by inhalation.
R36/37 Irritating to eyes and respiratory system.

Training advice
Provide adequate information, instruction and training for operators.

Regional representation: This information is given on the authorised Safety Data Sheet for
your country.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.

The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.

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