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    Pharm Examination: M. First

    Uploaded by

    Divya
    This document appears to be an exam for a pharmacology course, assessing students' knowledge of principles of toxicology. It contains two sections - long answers, where students must answer one of two questions in detail, and short answers, where they must concisely answer four of seven questions. The long answer questions cover topics like eye irritation tests, in vitro and in vivo micronuclei assays. The short answer questions topics include the definition and importance of an Investigational New Drug application, the principle of AMES tests, test item characterization, the importance of cardiovascular screening in safety pharmacology, and defining chromosomal aberration assays. The exam aims to evaluate students' understanding of key concepts and methods in toxicology

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    © All Rights Reserved
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    Pharm Examination: M. First

    Uploaded by

    Divya
    16 views3 pages
    This document appears to be an exam for a pharmacology course, assessing students' knowledge of principles of toxicology. It contains two sections - long answers, where students must answer one of two questions in detail, and short answers, where they must concisely answer four of seven questions. The long answer questions cover topics like eye irritation tests, in vitro and in vivo micronuclei assays. The short answer questions topics include the definition and importance of an Investigational New Drug application, the principle of AMES tests, test item characterization, the importance of cardiovascular screening in safety pharmacology, and defining chromosomal aberration assays. The exam aims to evaluate students' understanding of key concepts and methods in toxicology

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    This document appears to be an exam for a pharmacology course, assessing students' knowledge of principles of toxicology. It contains two sections - long answers, where students must answer one of two questions in detail, and short answers, where they must concisely answer four of seven questions. The long answer questions cover topics like eye irritation tests, in vitro and in vivo micronuclei assays. The short answer questions topics include the definition and importance of an Investigational New Drug application, the principle of AMES tests, test item characterization, the importance of cardiovascular screening in safety pharmacology, and defining chromosomal aberration assays. The exam aims to evaluate students' understanding of key concepts and methods in toxicology

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    16 views3 pages

    Pharm Examination: M. First

    Uploaded by

    Divya
    This document appears to be an exam for a pharmacology course, assessing students' knowledge of principles of toxicology. It contains two sections - long answers, where students must answer one of two questions in detail, and short answers, where they must concisely answer four of seven questions. The long answer questions cover topics like eye irritation tests, in vitro and in vivo micronuclei assays. The short answer questions topics include the definition and importance of an Investigational New Drug application, the principle of AMES tests, test item characterization, the importance of cardiovascular screening in safety pharmacology, and defining chromosomal aberration assays. The exam aims to evaluate students' understanding of key concepts and methods in toxicology

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 3

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    Jagadguru Sri Shivarathreeshwara University


    JSS College of Pharmacy, Mysuru -570 015
    M. Pharm First Sessional Examination February,2017
    . Note: Your answer should be specific to the questions asked.
    Draw neat labeled diagrams wherever necessory.

    Time:l.S hrs Subject: Principles of Toxicology Max. Marks : 30

    Semester: II Program: Pharmacology

    I. LONG ANSWERS (Answer any ONE questions) l0 x I : l0 Marks

    I . Define GLP. Brief about history, scope and principles of OECD on GLP

    2. Explain the principle and method involved in skin sensitization test as per OECD TG 406

    II. SHORT ANSWERS (Answer any FOUR questions) 5 x 4 = 20 Marks

    3. Explain the acute dermal toxicity procedure in rats as per OECD TG 402

    4. Give note on dose conversion formula based on metabolic factor.

    5. Explain how you will prepare 200 mg/kg, p.o dose of a drug X for rats and mice, clear

    information on amount of drug weighing and dose volume. Most important is minimum

    utilisation of drug and vehicle.

    6. Explain the recommended conditions on temperature, humidity, light, sound, photoperiod

    to be maintained in a small animal facility.

    7. Explain OECD TG 423 with starting dose 2000mg/kg

    t ***,i
    JSS Academy of Higher Education and Research
    JSS College of Pharmacy, Mysuru -570 015
    l-w
    M. Pharm First Sessional Examination Feb' 2018
    Note: Your ansv'er should be specilic to the queslions asked.
    [)rov, neal labeled diagrams v'herever necessary
    Subject:Pharmacologicaland'Ioxicological Max,Marks:30
    Time:1.5 h Screening Methods- II
    Semester: II Program: PharmacologY
    10 x 1=10 Marks
    I. LONG ANSWERS (Answer any ONE questions)
    1. Principle ar.rd method of28 repeated oral dose toxicity study

    ,Detir.re-general.mechanistic,regulatoryanddescriptivetoxicity'Writetheprinciplesof
    OECD
    (Answer any I'OIJR questions) 5x 4=20 Marks
    II. SHORT ANSWERS

    3. Principle of AMES test

    4. Write the responsibilities of Test Facility Management

    5. Discussthemethods-Invivomicronucleiassays

    6. Principles of in vivo chromosomal aberration assay

    7. Write ttre responsibilities of study director


    7-r\

    Jagadguru Sri Shivarath reeshwara University


    .ISS College of Pharmacy, Mysuru -570 015
    M. Pharm Second Sessional Examination April,2017
    Note: Your onsuzr should be speci/ic to the queslions ctsketl.
    Druu, ncut lubelcd diagrunt.t v'herevcr ncce.t.tory
    Time:l.S h Subject: Principles of Toxicolog- Max. Marks:30

    Semester: II Program: Pharmacology


    1., LONG ANSWERS (Ansrver any ONE questions) l0 x l=10 Marks
    I. Principle and method ofeye irritation test
    2. Discuss the nrethods - In vitro and In vivo micronuclei assays
    II. SIIORT ANSWERS (Answer any FOUR questions) 51 4=20 M:rrks

    J. Dellnition and importance of IND

    4. Principle of AMES test

    5. Deflne test item characterization

    6. t'r-ote on imporlance of CVS screening in salety phan.r.racology

    7- Define chromosomal aberration assav

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